Glycerylphosphocholine Ingawedzera Sei Simba Rehuropi Hwako?

Glycerylphosphocholine (GPC, inozivikanwawo seL-alpha-glycerylphosphorylcholine kana alphacholine)itsime recholine rinowanikwa muchisikigo rinowanikwa muzvikafu zvakasiyana-siyana (kusanganisira mukaka wezamu) uye mumasero ese evanhu. Ine huwandu hushoma hwecholine. GPC imorekuru inonyungudika mumvura yakaratidzwa kuva sosi ine simba yecholine yekiriniki kupfuura choline kana phosphatidylcholine (PC) kubva mukudya kana zvekudya zvinovaka muviri.

GPC inonwiwa zvakanaka uye inotsemuka mukati me enterocytes kuita glycerol-1-phosphate necholine. Mushure mekunwa GPC, huwandu hwe choline muplasma hwakawedzera nekukurumidza uye hwakaramba hwakakwira kwemaawa gumi. Kuwanda kwe choline muplasma kunoita kuti ifambe zvakanaka kuburikidza neropa-uropi. Izvi zvinowedzera nzvimbo dze choline mukati memasero etsinga, uko inoshandiswa kugadzira PC ne acetylcholine.

Muchimiro, α-GPC chinhu chinonzi choline chinosungirirwa ku glycerol molecule kuburikidza neboka re phosphate, uye i choline ine phospholipid. Huremu hwecholine hwakanyanya, hunosvika 40%, zvinoreva kuti 1000 mg ye α-GPC inogona kugadzira inenge 400 mg ye free choline.

Choline chinhu chakakosha chinowanikwa muzvigadzirwa zvemukaka nemazai zvinobatsira masero kuchengetedza membranes awo. Choline pachayo inodiwawo pakugadzira acetylcholine. Kunyange zvazvo alpha-GPC nedzimwe choline dzakadai sephosphatidylcholine nelecithin dzichigona kukurudzira kugadzirwa kweacetylcholine, alpha-GPC inonyanya kunaka nekuti mafuta ayo anoita kuti zvive nyore kumasero kunyudza. Zvinopfuura 90% zvephosphatidylcholine zvinonyudzwa nemidziyo yelymphatic, nepo α-GPC ichinyanyonyudzwa neportal vein, saka kushanda zvakanaka kwemushonga wekunyudza kwakakwira, nokudaro zvichisimudzira kugadzirwa kweacetylcholine zvinobudirira. Acetylcholine ineurotransmitter inoita basa guru mukudzora mashandiro europi uye kudzora tsandanyama. Kunyangwe tichigona kudya choline kuburikidza nechikafu, huwandu hweacetylcholine hunoderera nekukura.

Mabhenefiti eGPC Yakavakirwa Pakutsvagisa

Basa rehuropi

• Inovandudza ndangariro, kuisa pfungwa uye nguva yekuita zvinhu muvanhu vakuru nevadiki
• Inokurudzira kugadzirwa nekuburitswa kweacetylcholine (ACh) kubva kuma neuron pamwe nemamwe masero.
• Inogona kutsiva kudzikira kweACh kunokonzerwa nekukwegura, kushomeka kweestrogen (kuenda kumwedzi, uye pamwe kushandisa mishonga yekudzivirira pamuviri nemuromo)
• Kuvandudza maitiro eEEG
• Inowedzera kugadzirwa kwedopamine, serotonin uye GABA18.
• Kuvandudza mashandiro emitochondrial panguva yekushushikana kwe ischemia/oxidative
• Inodzivirira kudzikira kwenhamba dzemasero europi neACh receptor, mashandiro emhasuru uye kugadzirwa kwemahormone ekukura nekuda kwezera.
• Kukurudzira kuburitswa kwehomoni yekukura muvanhu vakuru nevadiki
• Inowedzera kuomeswa kwemafuta, simba remhasuru uye nguva yekuita chimwe chinhu, zvichida zvichivandudza kuenzana, kunyanya muvanhu vakuru.

Kugadziriswa kweUropi uye Rutsigiro rweAlzheimer's/Dementia

• Inovandudza kupora kweuropi mushure mekurohwa nestroke, kukuvara kweuropi kwakakuvara, uye anesthesia (asati avhiyiwa uye mushure mekuvhiyiwa).
• Kugadzirisa tsinga dzeropa neuropi dzakakuvadzwa neBP
• Inovandudza kugona kuziva uye maitiro ekugarisana nevamwe muchirwere cheAlzheimer, vascular/senile dementia, uye chirwere cheParkinson.
• Deredza kuderera kwehuwandu hwehuropi kwakafanana nechirwere cheAlzheimer's
• Inogona kubatsira muzvirwere zvinoda kugadziriswa kwemyelin uye Duchenne muscular dystrophy Choline inoshanda mu metabolism yemunhu uye GPC

Hunhu hwakasiyana senzvimbo ine simba yecholine, chinhu chinovaka acetylcholine uye chinhu chinokurudzira kugadzirwa kwayo nekuburitswa kwayo.

• Acetylcholine ineurotransmitter muuropi uye inoshandura zviratidzo kune dzimwe nzvimbo mumuviri, inokosha pakubata tsandanyama, ganda, kufamba kwemudumbu, uye mamwe mabasa enyama. Kusiyana necholine/PC inopihwa kuburikidza nekudya kana kuwedzerwa, kuwedzerwa kweGPC kwakaratidzwa kuva nemhedzisiro yakakosha pakugadzirwa kweACh uye kuburitswa kwayo kubva mumasero echolinergic.

Kuwedzera GPC kunoita kuti zviratidzo zve cholinergic zviwedzere muma neuron nemamwe masero anogona kugadzira acetylcholine. Izvi zvinobatsira zvikuru kana huwandu uye kushanda zvakanaka kwema neuron e cholinergic kwadzikira nekuda kwekukwegura kwakajairika kana maitiro akasiyana-siyana ekuora. Kuwedzera GPC kune mukana wekugadzirisa zvishoma kukanganisa uku nekuti kunokonzera kuwedzera nekukurumidza kweplasma choline, iyo ine simba rakasimba pa enzymes ne transporters munzira idzi.

Chivako che phosphatidylcholine (PC)

• PC ndeye phospholipids uye chinhu chakakosha che membrane dzemasero uye mitochondrial membranes. Kugona kwekuwedzera GPC kubatsira kupora kwestroke, pamwe nekudzivirira kudzikira kwehuwandu hweACh receptors mumasero etsinga kana uropi, humwe humbowo hwekubatsira kwayo kuchengetedza membrane yetsinga kuburikidza nePC synthesis.

Kuumbwa kwesphingomyelin

• Sphingomyelin chikamu che myelin sheath chinofukidza nekudzivirira ma neuron netsinga. Nokudaro, kuwedzerwa kweGPC kunogona kubatsira mune chero mamiriro ezvinhu ane kudiwa kwakanyanya kwekugadzirisa myelin, senge neuropathy, multiple sclerosis, nezvimwe zvirwere zvinosanganisira kubviswa kwemyelin uye autoimmune yetsinga. Kutakurwa kwemafuta mukati nekunze kwemasero.

• PC inodiwa pakugadzirwa nekuburitswa kwezvikamu zveVLDL. MaTriglycerides anosiya chiropa mukati mezvikamu zveVLDL, izvo zvinotsanangura kuti nei kushomeka kwecholine kuchiwedzera njodzi yechirwere chechiropa chine mafuta. PC inogona kuwanikwa kubva muzvikafu kana zvekudya zvinovaka muviri; zvisinei, PC ye phospholipids uye lipoproteins haiwanikwe zvakananga kubva kuPC inodyiwa kana yakagadzirwa kare. Inogadzirwa kubva kune zvakasiyana-siyana zve choline precursors (kusanganisira GPC), saka kumedza PC haisiriyo nzira inonyanya kushanda yekuwedzera PC pool yemuviri.
Tsigira kufamba kwembeu

• GPC chinhu chakakosha pakubatanidzwa kweDHA (docosahexaenoic acid), zvichiita PC-DHA. DHA-PC complex inoshandiswa mumhando dzemasero anoshanda zvakanyanya akadai semasero anoona chiedza cheretinal uye masero embeu. DHA-PC inowedzera kuyerera kwemembrane, izvo zvakakosha pakushanda zvakanaka kwembeu. Urume hune huwandu hwakawanda hweGPC; masero epididymal anokura masero embeu anotorwa kubva muGPC pool uye anogadzira PC-DHA. Kuderera kweGPC nePC-DHA mumbeu kunogona kuwedzera njodzi yekudzikira kwekufamba kwembeu.

Kuenzanisa kweGPC neAcetyl-L-Carnitine (ALCAR)

• Mukudzidza kwakaitwa pavarwere vane chirwere cheAlzheimer chakakwira, GPC yakakonzera kuvandudzika kukuru muzvikamu zvakawanda zvepfungwa dzepfungwa zvichienzaniswa neALCAR. Kunyange zvazvo mishonga yese ichitsigira kuwedzera kweacetylcholine, zvinofungidzirwa kuti panogona kunge paine mhedzisiro yekubatana pakati pekuwedzera mishonga miviri iyi, sezvo GPC ichipa choline ukuwo ALCAR ichipa chikamu cheacetyl chekugadzira acetylcholine.

Kushanda pamwe chete pakati peGPC nemishonga. Kuwedzerwa kweGPC hakufungidzirwi kuti kunokanganisa chero mishonga yakagadzirirwa kuvandudza mashandiro ehuropi. Kutaura zvazviri, nekuda kwekubatsira kwayo panzira dzecholinergic uye kuvandudza mashandiro emasero etsinga dzetsinga, inogona kuwedzera mabhenefiti ayo. GPC inogona kuwedzera mhedzisiro yeacetylcholinesterase AChE inhibitors nekuti inogona kuwedzera huwandu hweACh mu synaptic cleft, nepo mishonga iyi ichinonotsa kuora kwayo.

Pamusoro pezvo, zvichienderana nezvidzidzo zvemhuka, GPC inogona kuwedzera kugadzirwa kwedopamine, serotonin, kana GABA muuropi, uye GPC inogona kuwedzera mhedzisiro yezvinodzivisa kudzokororwa kwema neurotransmitters aya.

Suzhou Myland Pharm & Nutrition Inc. ikambani yakanyoreswa neFDA inopa Alpha GPC powder yemhando yepamusoro uye yakachena.

KuSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. Upfu hwedu hweAlpha GPC hwakaedzwa zvakasimba kuti huve hwakachena uye hune simba, zvichiita kuti uwane chinowedzera chemhando yepamusoro chaunogona kuvimba nacho. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako kana kusimudzira hutano hwese, upfu hwedu hweAlpha GPC ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira dzeR&D dzakanyatsogadzirwa, Suzhou Myland Pharm yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidzana uye yakava kambani itsva yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland Pharm ikambani yakanyoreswa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinogona kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.