Glycerylphosphocholine Inogona Sei Kuwedzera Huropi Hwako Simba?

Glycerylphosphocholine (GPC, inozivikanwawo seL-alpha-glycerylphosphorylcholine kana alphacholine)inzvimbo inowanzoitika yecholine inowanikwa mune zvakasiyana-siyana zvekudya (kusanganisira mukaka wezamu) uye mumasero evanhu Iine zvishoma zvecholine. GPC is a water-soluble molecule iyo yakaratidzwa kuva yakanyanya simba sosi yekiriniki choline kupfuura choline kana phosphatidylcholine (PC) kubva mukudya kana kuwedzera.

GPC inoitwa nemuromo inobatwa zvakanaka uye inotsemurwa mukati me enterocytes mu glycerol-1-phosphate uye choline. Mushure mekudya GPC, choline mazinga mu plasma akasimuka nokukurumidza uye akaramba akakwirira kwemaawa 10. Iyo yakakwira plasma yekumisikidza gradient yecholine inosimudzira kufambisa kwayo kwakanaka kuyambuka ropa-brain barriers. Izvi zvinowedzera zvitoro zvecholine mukati meeuroni, uko inoshandiswa kugadzira PC uye acetylcholine.

Zvimiro, α-GPC inhengo yecholine inosungirirwa kune glycerol molecule kuburikidza neboka rephosphate, uye inonzi choline ine phospholipid. Izvo zviri mucholine zvakanyanya kwazvo, zvinoverengera nezve 40%, izvo zvinoreva kuti 1000 mg ye α-GPC inogona kuburitsa nezve 400 mg yemahara choline.

Choline chinhu chakakosha chekudya chinowanikwa muzvigadzirwa zvemukaka uye mazai anobatsira masero kuchengetedza membranes. Choline pachayo inofanirwawo kugadzira acetylcholine. Kunyange zvazvo alpha-GPC nedzimwe choline dzakadai se phosphatidylcholine uye lecithin zvinogona kukurudzira kugadzirwa kweacetylcholine, alpha-GPC inonyanya kudarika nokuti lipids yainopa inoita kuti zvive nyore kuti masero atore, Kupfuura 90% ye phosphatidylcholine inotorwa ne lymphatic vessels. , nepo α-GPC inonyanya kubatwa nevhavha yevhavha, saka kushandiswa kwepamusoro kwakakwirira, nokudaro kukurudzira kugadzirwa kweacetylcholine zvakanyanya. Acetylcholine inonzi neurotransmitter inoita basa rakakosha mukudzora kushanda kwehuropi uye kutonga kwemhasuru. Kunyangwe isu tichigona kudya choline kuburikidza nekudya, huwandu hweacetylcholine hunoderera nezera.

Zvakanakira Tsvagurudzo-Yakavakirwa GPC

Basa rehuropi

• Inovandudza chiyeuchidzo, kuisa pfungwa uye nguva yekuita kune vanhu vakuru uye vaduku
• Inokurudzira kugadzirwa uye kusunungurwa kweacetylcholine (ACh) kubva kune neuroni uye zvichida mamwe masero.
• Inogona kubhadhara kuderera kweACh kunokonzerwa nekuchembera, kushomeka kweesrogen (kuenda kumwedzi, uye pamwe nekushandisa nzira yekudzivirira nemuromo)
• Kuvandudza maitiro eEEG
• Inowedzera kugadzirwa kwe dopamine, serotonin uye GABA18.
• Kuvandudza mitochondrial basa panguva ye ischemia / oxidative stress
• Inorwisa kuderera kunoenderana nezera musero reuropi uye nhamba dzekugamuchira ACh, kushanda kwemhasuru uye kugadzirwa kwehomoni.
• Kurudzira kukura kwehomoni muvaduku nevakuru vakuru
• Inowedzera mafuta oxidation, simba remhasuru uye nguva yekuita, zvichida kuvandudza kuenzanisa, kunyanya kune vakwegura.

Brain Repair uye Alzheimer's/Dementia Tsigiro

• Inovandudza kupora kwehuropi mushure mekurova, kukuvara kwehuropi, uye anesthesia (pamberi uye mushure mekuvhiyiwa).
• Gadzirisa ropa-brain barrier tissue yakakuvadzwa nehypertension
• Inovandudza cognition uye magariro evanhu muAlzheimer's disease, vascular/senile dementia, uye Parkinson's disease.
• Kuderedza kuderera kwehuropi zvakafanana nechirwere cheAlzheimer
• Inogona kubatsira muzvirwere zvinoda kugadziriswa kwemyelin uye Duchenne muscular dystrophy Choline inoshanda mumetabolism yevanhu uye GPC.

Yakasarudzika zvivakwa seyakasimba sosi yecholine, chivako cheacetylcholine uye chinhu chinokurudzira kuumbwa kwayo nekuvanzika.

• Acetylcholine inonzi neurotransmitter muuropi uye chiratidzo che transducer kune imwe nzvimbo mumuviri, inokosha pakugadzirisa mhasuru, ganda reganda, gastrointestinal motility, uye mamwe mabasa enyama. Kusiyana necholine / PC inopiwa kuburikidza nekudya kana kuwedzera, GPC yekuwedzera yakaratidzwa kuva nemafungiro makuru ekusimudzira pakugadzirwa kwe ACh uye kusunungurwa kwayo kubva kumasero echolinergic.

Kuwedzerwa kweGPC kunoguma nekuwedzera cholinergic siginecha muma neuroni uye mamwe masero anogona kugadzira acetylcholine. Izvi zvinonyanya kubatsira kana iyo nhamba uye inoshanda basa recholinergic neurons yakaderedzwa nekuda kwekuchembera kwakajairwa kana maitiro akasiyana-siyana ekuderera. Kuwedzerwa neGPC kune mukana wekubhadhara zvishoma kune kukanganisa uku nokuti kunokonzera kukurumidza kukwira kweplasma choline, iyo inoshandisa simba rakasimba re substrate pama enzymes nevatakuri munzira idzi.

Kuvaka block ye phosphatidylcholine (PC)

• PC ndeye phospholipids uye inokosha chikamu chesero membranes uye mitochondrial membranes. Kugona kweGPC supplementation kuti ibatsire kupora kwekurohwa, pamwe nekurwisa kuderera kwezera-kwezera muhuwandu hwe ACh receptors mumasero etsinga kana huropi, humwe uchapupu hwekubatsira kwayo kune neuronal membrane kuchengetedza kuburikidza nePC synthesis.

Kuumbwa kwe sphingomyelin

• Sphingomyelin inhengo yemyelin sheath inovhara uye insulates neurons uye nerve. Nokudaro, GPC supplementation inogona kubatsira mune chero mamiriro ezvinhu nekuwedzera kudiwa kwekugadzirisa myelin, zvakadai seuropathy, multiple sclerosis, uye mamwe mamiriro anosanganisira demyelination uye autoimmunity yehutachiwana. Kutakurwa kwemafuta mukati nekunze kwemasero

• PC yakakosha pakugadzirwa uye kuvharwa kweVLDL particles. Triglycerides inosiya chiropa mukati meVLDL zvimedu, izvo zvinotsanangura kuti nei kushomeka kwecholine kuchiwedzera njodzi yechirwere chechiropa chine mafuta. PC inogona kuwanikwa kubva kune zvekudya zvinyorwa kana zvinowedzera; zvisinei, PC ye phospholipids uye lipoproteins haiwanikwe zvakananga kubva kune yakamedzwa kana preformed PC. Iyo inogadzirwa kubva kwakasiyana-siyana choline precursors (kusanganisira GPC), saka kupinza PC haisiriyo yakanyanya kunaka nzira yekuwedzera PC yemuviri dziva.
Support sperm motility

• GPC chinhu chinokosha pakubatanidzwa kweDHA (docosahexaenoic acid), ichiita PC-DHA. DHA-PC yakaoma inoshandiswa mumhando dzesero dzinoshanda zvakanyanya senge retinal chiedza-inonzwa masero uye urume masero. DHA-PC inowedzera membrane fluidity, iyo yakakosha kune hutano hwesperm basa. Urume hune huwandu hwakanyanya hweGPC; epididymal masero anorima sperm masero anotorwa kubva padziva reGPC uye anogadzira PC-DHA. Kudzika kweGPC nePC-DHA muurume kunogona kuwedzera njodzi yekuderedzwa kwembeu motility.

Kuenzanisa kweGPC uye Acetyl-L-Carnitine (ALCAR)

• Muchidzidzo chevarwere vane chirwere cheAlzheimer chepamusoro, GPC yakaguma nekuvandudzwa kukuru mune dzakawanda neuropsychological parameters zvichienzaniswa neALCAR. Kunyange zvazvo mishonga yose inotsigira kuwedzera kweacetylcholine, zvinofungidzirwa kuti panogona kuva nekubatana kwekuita pakati pekuwedzera mishonga miviri, sezvo GPC inopa choline apo ALCAR inopa chikamu cheacetyl chekugadzirwa kweacetylcholine.

Inogona kuwirirana pakati peGPC nemishonga. GPC supplementation haifungidzirwe kupindira zvisina kunaka chero mishonga yakagadzirirwa kuvandudza kushanda kwehuropi. Muchokwadi, nekuda kwemabhenefiti ayo pacholinergic nzira uye nekuvandudza neuronal cell membrane basa, inogona kunyatso wedzera mabhenefiti avo. GPC inogona kuwedzera migumisiro yeacetylcholinesterase AChE inhibitors nokuti inogona kuwedzera huwandu hwe ACh mu synaptic cleft, asi mishonga iyi inononoka kuparara kwayo.

Mukuwedzera, maererano nezvidzidzo zvemhuka, GPC inogona kuwedzera kugadzirwa kwe dopamine, serotonin, kana GABA muuropi, uye GPC inogona kuwedzera migumisiro ye reuptake inhibitors yeva neurotransmitters.

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yemhando yepamusoro uye yakakwirira-kuchena Alpha GPC hupfu.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Alpha GPC poda yakaedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu Alpha GPC hupfu ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.