Nebudiriro yemagariro evanhu, vanhu vari kuramba vachitarisa nyaya dzehutano. Nhasi ndinoda kukuzivisai mamwe mashoko pamusoro pechirwere cheAlzheimer, chinova chirwere chepfungwa chinofambira mberi chinokonzera kurasikirwa nendangariro uye mamwe mano enjere.
Chokwadi
Chirwere cheAlzheimer's, iyo inonyanya kuzivikanwa nzira yedementia, izwi rizere rendangariro nekurasikirwa nepfungwa.
Chirwere cheAlzheimer chinouraya uye hachina mushonga. Icho chirwere chisingaperi chinotanga nekurasika kwendangariro uye pakupedzisira chinotungamira mukukuvadzwa kwakanyanya kwehuropi.
Chirwere ichi chinopihwa zita raDr. Alois Alzheimer. Muna 1906, neuropathologist yakaita autopsy pahuropi hwemukadzi akafa mushure mekuvandudza kutadza kutaura, hunhu husingafungidzirwe uye kurasikirwa nekurangarira. Dr. Alzheimer akawana amyloid plaques uye neurofibrillary tangles, iyo inonzi zviratidzo zvechirwere.
Zvikonzero:
Zera - Mushure memakore makumi matanhatu nemashanu, mukana wekuita chirwere cheAlzheimer unowedzera kaviri makore mashanu ega ega. Kune vanhu vazhinji, zviratidzo zvinotanga kuoneka mushure memakore makumi matanhatu.
Nhoroondo Yemhuri - Genetic factors dzinoita basa munjodzi yemunhu.
Head Trauma - Panogona kunge paine chinongedzo pakati pechirwere ichi uye kudzokorora kushungurudza kana kurasikirwa kwekuziva.
Utano hwemwoyo - Chirwere chemoyo chakadai seBP, high cholesterol uye chirwere cheshuga chinogona kuwedzera njodzi yevascular dementia.
Ndezvipi zviratidzo zvishanu zvekunyevera zvechirwere cheAlzheimer?
Zvinogoneka zviratidzo: kurasikirwa kwendangariro, kudzokororwa kwemibvunzo uye zvirevo, kutadza kutonga, kusaisa zvinhu, manzwiro uye kuchinja kweunhu, kuvhiringidzika, kunyengera uye paranoia, kusafungira, kubatwa, kunetseka kumedza.
Ndeupi musiyano uripo pakati pedementia nechirwere cheAlzheimer?
Dementia nechirwere cheAlzheimer zviri zviviri zvirwere zvine chekuita nekudzikira kwekuziva, asi pane misiyano pakati pazvo.
Dementia chirwere chinosanganisira kuderera kwekuziva basa kunokonzerwa nezvakawanda zvinokonzeresa, zvinosanganisira zviratidzo zvakaita sekurasika ndangariro, kuderedzwa kwekufunga, uye kusafunga zvakanaka. Chirwere cheAlzheimer ndiyo yakajairika mhando yedementia uye inoverengera huwandu hwezviitiko zvedementia.
Chirwere cheAlzheimer chirwere chinoenderera mberi neurodegenerative icho chinowanzobata vanhu vakuru uye chinoratidzwa neabnormal protein deposition muuropi, zvichiita kuti neuronal kukuvara uye kufa. Dementia ishoko rakakura rinosanganisira kuderera kwekuziva kunokonzerwa nezvikonzero zvakasiyana, kwete chirwere cheAlzheimer chete.
Zvinofungidzirwa nenyika
Centers for Disease Control and Prevention inofungidzira kuti vangangoita 6.5 miriyoni vekuAmerica vane chirwere cheAlzheimer. Chirwere ichi ndicho chechishanu chechikonzero chekufa kwevanhu vakuru vanopfuura makumi matanhatu neshanu muUnited States.
Mutengo wekuchengeta vanhu vane chirwere cheAlzheimer kana imwe dementias muUnited States unofungidzirwa kuita madhora mazana matatu nemakumi mana nemashanu muna 2023.
kutanga kwechirwere cheAlzheimer
Chirwere cheAlzheimer's chirwere chisingawanike chinobata vanhu vari pasi pemakore makumi matanhatu nemashanu.
Chirwere cheAlzheimer's chekutanga-tanga chinowanzoita mumhuri.
Tsvakurudzo
Kurume 9, 2014-Muongororo yekutanga-ye-yayo, vatsvakurudzi vanotaura kuti vakagadzira kuongororwa kweropa kunogona kufanotaura nekururama kunoshamisa kana vanhu vane hutano vachave nechirwere cheAlzheimer.
Mbudzi 23, 2016 - US drugmaker Eli Lilly akazivisa kuti ichapedza Phase 3 yekiriniki yekuyedza yeAlzheimer's drug solanezumab. "Chiyero chekuderera kwekuziva hakuna kuderera zvakanyanya muvarwere vanobatwa ne solanezumab kana vachienzaniswa nevarwere vanobatwa ne placebo," kambani yakataura mune chirevo.
Kukadzi 2017 - Kambani yemishonga Merck inombomira kuyedzwa kwekupedzisira kwechirwere cheAlzheimer's verubecestat mushure meongororo yakazvimirira yakawana mushonga uyu "usingashande."
Kukadzi 28, 2019 - The Nature Genetics yakaburitsa chidzidzo ichiburitsa mana matsva emajini akasiyana anowedzera njodzi yechirwere cheAlzheimer. Aya majini anoita seanoshanda pamwe chete kudzora mashandiro emuviri anokanganisa kukura kwechirwere.
Kubvumbi 4, 2022 - Chidzidzo chakaburitsa chinyorwa ichi chakawana mamwe majini makumi mana nemaviri ane hukama nekukura kwechirwere cheAlzheimer.
Kubvumbi 7, 2022 - The Centers for Medicare and Medicaid Services yakazivisa kuti ichaganhurira kuvharwa kwemushonga une gakava uye unodhura weAlzheimer's Aduhelm kune vanhu vari kutora chikamu mumiyedzo yekiriniki inokodzera.
Chivabvu 4, 2022 - Iyo FDA yakazivisa kubvumidzwa kwechirwere cheAlzheimer's diagnostic test. Ndiyo yekutanga in vitro diagnostic test inogona kutsiva maturusi akadai sePET scans anoshandiswa parizvino kuongorora chirwere cheAlzheimer.
Chikumi 30, 2022 - Masayendisiti akawana geni rinoita kunge rinowedzera njodzi yemukadzi yekubatwa nechirwere cheAlzheimer, ichipa ruzivo rutsva rwekuti nei vakadzi vachinyanya kubatwa nechirwere ichi kupfuura varume. Jeni, O6-methylguanine-DNA-methyltransferase (MGMT), inoita basa rakakosha mukukwanisa kwemuviri kugadzirisa kukuvara kweDNA muvarume nevakadzi. Asi vaongorori havana kuwana chinongedzo pakati peMGMT nechirwere cheAlzheimer muvarume.
Ndira 22, 2024—Chidzidzo chitsva mujenari JAMA Neurology chinoratidza kuti chirwere cheAlzheimer chinogona kuongororwa “nechokwadi chepamusoro” nekuona puroteni inonzi phosphorylated tau, kana p-tau, muropa remunhu. Chirwere chinyararire, chinogona kuitwa kunyange zviratidzo zvisati zvatanga kuoneka.
Nguva yekutumira: Jul-09-2024
