Munyika yezvekudya zvinowedzera, magnesium alpha-ketoglutarate poda yakagamuchira kutariswa kwakapararira kune yayo inogona kubatsira hutano. Komboni iyi inozivikanwa nebasa rayo mukugadzira simba, kudzoreredza tsandanyama, uye hutano hwese metabolic. Kana iwe uchida kubatanidza iyi yekuwedzera mune yako yemazuva ese maitiro, zvakakosha kuti uzive kwaunotenga yepamusoro-mhando magnesium alpha ketoglutarate poda online.
Alpha-ketoglutarate (AKG) yagara iri yakakurumbira yemitambo yekuwedzera inowanzoshandiswa munharaunda yekusimba, asi kufarira mumorekuru uyu kwapinda mumunda wekutsvaga kwekuchembera nekuda kwebasa rayo repakati mumetabolism. AKG inowanzoitika endogenous intermediary metabolite iri chikamu cheKrebs cycle, zvichireva kuti miviri yedu inoigadzira.
AKG imorekuru inobatanidzwa mune dzakawanda metabolic uye cellular nzira. Inoshanda semupi wesimba, inotangira amino acid kugadzirwa uye cell signing molecule, uye inodzora epigenetic maitiro. Iyo imorekuru rakakosha mukutenderera kweKrebs, inoronga kumhanya kwese kwechipenyu che citric acid kutenderera. Inoshanda nenzira dzakasiyana-siyana mumuviri kubatsira kuvaka tsandanyama uye kubatsira kuporesa maronda, chinova chimwe chezvikonzero nei chakakurumbira munyika yekusimba. Dzimwe nguva, vatapi vehutano vanopa alpha-ketoglutarate intravenously kudzivirira kukuvadzwa kwemoyo kunokonzerwa nematambudziko ekuyerera kweropa panguva yekuvhiyiwa kwemoyo uye kudzivirira kurasikirwa kwemhasuru mushure mekuvhiyiwa kana kushungurudzika.
AKG inoshandawo senge nitrogen scavenger, kudzivirira nitrogen kuwandisa uye kudzivirira kuunganidzwa kweammonia yakawandisa. Iyo zvakare yakakosha sosi ye glutamate uye glutamine, iyo inomutsa mapuroteni synthesis uye inodzivisa kuparara kweprotein mumamhasuru. Uyezve, inodzora gumi nerimwe translocation (TET) enzymes inobatanidzwa muDNA demethylation uye Jumonji C domain ine lysine demethylase, iyo huru histone demethylase Enzymes. Nenzira iyi, mutambi akakosha mukugadzirisa gene uye kutaura.
【Ko AKG inononoka kuchembera here? 】
Pane humbowo hwekuti AKG inogona kukanganisa kuchembera, uye zvidzidzo zvakawanda zvinoratidza kuti zvinoita. Imwe ongororo yakaratidza kuti AKG yakawedzera hupenyu hwevanhu vakuru C. elegans neanenge 50% nekudzivisa ATP synthase uye chinangwa cherapamycin (TOR). Muchidzidzo ichi, AKG yakaonekwa kuti haisi kungowedzera hupenyu chete asiwo inonokesa mamwe mapenotypes ane hukama nezera, sekurasikirwa kwekukurumidza kurongeka kwekufamba kwemuviri kunowanzoitika muhonye dzeC. elegans dzakakura.
【ATP synthase】
Mitochondrial ATP synthase is a enzyme ubiquitous inobatanidzwa mune simba metabolism mumasero akawanda ehupenyu. ATP ndeye membrane-yakasungwa enzyme inoshanda semutakuri wesimba kusimudzira cellular simba metabolism. Tsvagiridzo muna 2014 yakaratidza kuti kuti uwedzere hupenyu hweC. elegans, AKG inoda ATP synthase subunit beta uye inotsamira pane yakadzika TOR. Vatsvakurudzi vakawana kuti ATP synthase subunit β ipuroteni inosunga yeAKG. Vakaona kuti AKG inhibits ATP synthase, zvichiita kuti kuderera kweATP inowanikwa, kuderera kwekushandiswa kweokisijeni, uye kuwedzera kwe autophagy mune zvose nematode uye mammalian masero.
Iko kusungirirwa kwakananga kweATP-2 neAKG, iyo inobatanidza enzyme inhibition, kuderedzwa kwemazinga eATP, kuderedzwa kwekushandiswa kweokisijeni uye kuwedzerwa kwehupenyu hunenge hwakafanana kune iyo apo ATP synthase 2 (ATP-2) inobviswa zvakananga. Zvichienderana nezvakawanikwa izvi, vaongorori vakagumisa kuti AKG inogona kuwedzera hupenyu nekutarisa ATP-2. Chaizvoizvo, zviri kuitika pano ndezvekuti basa remitochondrial rakati radzivirirwa, kunyanya cheni yekutakura maerekitironi, uye ndiko kudzivirirwa kwacho kunotungamirira kuupenyu hwakawedzerwa hweC. elegans. Chinokosha kudzikisa mitochondrial basa zvakakwana pasina kuenda kure zvakanyanya kana zvinokuvadza. Naizvozvo, chirevo chekuti "rarama nekukurumidza, kufa uri mudiki" ndeyechokwadi, chete munyaya iyi, nekuda kwekudziviswa kweATP, honye inogona kurarama zvishoma uye kufa yakwegura.
[Alpha-ketoglutarate uye chinangwa cherapamycin (TOR)]
Zvidzidzo zvakasiyana-siyana zvakaratidza kuti inhibition yeTOR inogona kukanganisa kukwegura mumarudzi akasiyana-siyana, kusanganisira kuderedza kuchembera mumbiriso, kuderedza kuchembera muCaenorhabditis elegans, kuderedza kuchembera muDrosophila, nekugadzirisa hupenyu mumakonzo. AKG haibatanidzi zvakananga neTOR, kunyange ichikanganisa TOR, kunyanya nekudzivisa ATP synthase. AKG inotsamira, pamwe muchikamu, pane activated protein kinase (AMPK) uye forkhead bhokisi "mamwe" (FoxO) mapuroteni kuti ape hupenyu. AMPK inochengetedzwa cellular energy sensor inowanikwa mumarudzi akawanda, kusanganisira vanhu. Kana chiyero che AMP/ATP chakanyanya kukwirira, AMPK inogadziriswa, iyo inodzivisa TOR kusaina nekuita phosphorylation yeTOR inhibitor TSC2. Iyi nzira inogonesa maseru kunyatsogadzirisa metabolism yavo uye kuenzanisa chimiro chesimba ravo. FoxOs, boka diki re forkhead transcription factor family, rinoita basa rakakosha mukugadzirisa mhedzisiro ye insulin uye kukura kwezvinhu pamabasa akawanda, kusanganisira kuwanda kwesero, cell metabolism, uye apoptosis. Imwe ongororo inoratidza kuti kuwedzera hupenyu nekudzikisa kusaina kweTOR, iyo FoxO transcription factor PHA-4 inodiwa.
【α-ketoglutarate uye autophagy】
Pakupedzisira, autophagy inoshandiswa ne caloric restriction uye kudziviswa kwakananga kweTOR kwakawedzera zvakanyanya muC. elegans yakapiwa AKG yakawedzerwa. Izvi zvinoreva kuti AKG uye TOR inhibition inowedzera hupenyu kuburikidza nenzira imwe chete kana kuburikidza yakazvimirira / yakafanana nzira uye nzira dzinozopedzisira dzasangana pane imwechete yakadzika nhanho. Izvi zvinotsigirwa zvakare nezvidzidzo nezve mbiriso ine nzara uye mabhakitiriya, pamwe nevanhu mushure mekurovedza muviri, izvo zvakaratidza kuwedzera AKG mazinga. Kuwedzera uku kunofungidzirwa kuva mhinduro yenzara, munyaya iyi compensatory gluconeogenesis, iyo inoshandisa glutamate-yakabatana transaminases muchiropa kuti ibudise kabhoni kubva kuamino acid catabolism.
Magnesium ndiyo yechina yakanyanya kuwanda mumuviri wemunhu uye inotora chikamu mune zvinopfuura mazana matatu enzymatic reaction. Izvo zvakakosha pakugadzirwa kwesimba, mapuroteni synthesis, kutsikisa tsandanyama, uye kushanda kwetsinga. Magnesium inochengetedzawo rhythm yemwoyo yakajairika uye inogadzirisa BP.
Kunyangwe magnesium yakakosha, vanhu vazhinji havadye huwandu hwakaringana hwayo, zvichikonzera kushomeka kwe magnesium kunokanganisa hutano hwese. Zvokudya zvinowanzowanikwa zve magnesium zvinosanganisira miriwo mashizha mashizha, nzungu, mhodzi, zviyo zvakakwana uye nyemba.
Kudyidzana pakati pe magnesium uye alpha-ketoglutarate
1. Enzymatic reaction
Magnesium ions yakakosha pakuita kweakasiyana enzymes anobatanidzwa muKrebs cycle, kusanganisira iyo enzyme inoshandura alpha-ketoglutarate kuita succinyl-CoA. Uku kutendeuka kwakakosha pakuenderera mberi kweKrebs kutenderera uye kugadzirwa kweATP, iyo cellular simba mari.
Pasina magnesium yakakwana, aya maitiro enzymatic anogona kukanganisa, zvichikonzera kudzikiswa kwesimba rekugadzira uye kunogona kuitika metabolic dysfunction. Izvi zvinosimbisa kukosha kwekuchengetedza akaringana mazinga e magnesium kune yakakwana sero basa uye simba metabolism.
2. Kugadziriswa kwemaitiro emagetsi
Magnesium inoitawo basa mukugadzirisa metabolic nzira dzinosanganisira alpha-ketoglutarate. Semuenzaniso, magnesium inokanganisa basa reamino acid metabolism enzymes rine hukama neAKG. Shanduko yemamwe amino acids kuita α-ketoglutarate inhanho yakakosha mukugadzirwa kwesimba uye nitrogen metabolism. Mukuwedzera, magnesium yakaratidzwa kuti inogadzirisa basa remakiyi ekuratidza nzira, dzakadai semTOR nzira inobatanidzwa mukukura kwesero uye metabolism. Nekukanganisa nzira idzi, magnesium inogona kukanganisa mazinga uye kushandiswa kwealpha-ketoglutarate mumuviri.
3. Antioxidant properties
Alpha-ketoglutarate inozivikanwa neiyo antioxidant zvimiro, inobatsira kuderedza oxidative kusagadzikana mukati memasero. Magnesium yakaratidzawo kuti ine antioxidant mhedzisiro. Kana magnesium iripo muhuwandu hwakakwana, inowedzera iyo antioxidant kugona kwealpha-ketoglutarate, ichipa kumwe kudzivirirwa kubva mukukuvadzwa kweiyo oxidative. Oxidative stress yakabatanidzwa kune zvakasiyana-siyana zvehutano zvinetso, kusanganisira chirwere chisingaperi uye kukwegura. Nekutsigira iyo antioxidant mabasa ealpha-ketoglutarate, magnesium inogona kubatsira kune cellular hutano uye hupenyu hurefu.
Magnesium alpha-ketoglutarate ikomboni inosanganisa magnesium nealpha-ketoglutarate, kiyi yepakati muKrebs cycle (inozivikanwawo secitric acid cycle), iyo yakakosha kumasero kugadzirwa kwesimba kwakakosha. Inowanzo shandiswa mune zvekudya zvinowedzera nekuda kwezvinogona kubatsira mukusimudzira kuita kwemitambo, kupora uye hutano hwese metabolic.
1. Kuvandudza kugadzirwa kwesimba
Imwe yemabhenefiti makuru e Magnesium Alpha KetoglutarateUpfu ndiko kugona kwayo kuwedzera masimba masimba. AKG inoita basa rakakosha mukutenderera kweKrebs, iyo ine basa rekushandura chikafu kuita simba. Nekuwedzera neAKG, unotsigira maitiro ekugadzira simba remuviri wako. Pamusoro pezvo, magnesium yakakosha pakugadzirwa kweATP (adenosine triphosphate), mari yemusero.
2. Kuvandudza kushanda kwemhasuru uye kupora
Magnesium inozivikanwa nebasa rayo mukudonhedza tsandanyama uye kuzorora, izvo zvakakosha pakuita kwakaringana. AKG inogonawo kubatsira kuderedza kurwadza kwemhasuru uye kupfupisa nguva yekudzoreredza mushure mekushanda kwakanyanya. Nekubatanidza ichi chekuwedzera mumaitiro ako ezuva nezuva, unogona kuwedzera kutsungirira, kuderera kuneta, uye nekukurumidza kupora, zvichikubvumidza kusundira miganhu yako.
3. Cognitive Support
Utano hwepfungwa huri kuwedzera kunetseka kwevanhu vazhinji, kunyanya patinenge takura. Tsvagiridzo inoratidza kuti AKG inogona kunge iine neuroprotective zvimiro zvinogona kubatsira kutsigira hutano hwehuropi uye kugona basa. Magnesium inoitawo basa mukutonga neurotransmitter, iyo yakakosha kune mafungiro uye kugona kwekuziva. Nekubatanidza izvi zviviri zvinosanganiswa, magnesium alpha ketoglutarate poda inogona kubatsira kuvandudza kutarisa, kurangarira, uye kujeka kwepfungwa kuzere.
4. Tsigira kukwegura kwakanaka
Sezvatinokura, miviri yedu inochinja zvakasiyana-siyana zvinogona kukanganisa utano hwedu. Kuwedzera ne magnesium alpha ketoglutarate poda inogona kubatsira kuderedza mamwe emhedzisiro iyi. Zvidzidzo zvemhuka zvakabatanidza AKG nekuwedzera hupenyu hurefu, uye kugona kwayo kutsigira hutano hweserura kunogona kuita kuti kuve neutano hwekuchembera. Magnesium, kune rumwe rutivi, yakakosha pakuchengetedza kusimba kwemapfupa uye kudzivirira zvirwere zvine chokuita nezera. Pamwe chete, vanogona kukurudzira hupenyu hune hutano, hune simba zvakanyanya sezvatinokura.
5. Kuwedzera immune function
Simba rekudzivirira zvirwere rakakosha kuhutano hwese, kunyanya munyika yanhasi. Magnesium inoita basa rakakosha mukushanda kwe immune, kubatsira kudzora kuzvimba uye kutsigira nzira dzekudzivirira dzemuviri. AKG inogonawo kunge iine immune-boosting zvivakwa, zvichiita kuti musanganiswa uyu uve mubatsiri ane simba mukuchengetedza mhinduro ine hutano.
Nepo izvo zvekutanga zvinongedzo zvealpha-ketoglutarate uye magnesium zvingave zvakafanana mune akasiyana ekuwedzera, akati wandei zvinhu zvinogona kukanganisa kushanda kwavo uye kunaka. Heano mamwe makuru ekufungisisa:
1.Dosage fomu uye dosage
Haasi ese AKG magnesium ekuwedzera anogadzirwa akaenzana. Magadzirirwo anogona kusiyana zvakanyanya pakati pemhando. Mimwe inogona kunge iine zvimwe zvinhu, senge mavhitamini, mamineral, kana mishonga yemakwenzi, inogona kuwedzera kana kushandura mhedzisiro yechinhu chikuru.
2. Bioavailability
Bioavailability zvinoreva mwero uye mwero wekuti chinhu chinopinzwa muropa. Mamwe maitiro e magnesium, akadai se magnesium citrate kana magnesium glycinate, ane bioavailable kupfuura mamwe maitiro e magnesium, akadai se magnesium oxide. Chimiro che magnesium chinoshandiswa mukuwedzera chinogona kukanganisa zvakanyanya mashandisiro anoita muviri wako.
Saizvozvowo, iyo fomu yealpha-ketoglutarate inokanganisa kubatwa kwayo. Tarisa ma supplements anoshandisa emhando yepamusoro, bioavailable mafomu emakomponi ese ari maviri kuti uve nechokwadi chekuti unowana iyo yakanyanya bhenefiti.
3. Kuchena uye Unhu
Kuchena uye kunaka kwezvinhu zvinoshandiswa mukuwedzera zvakakosha pakubudirira kwayo nekuchengetedza. Zvimwe zvigadzirwa zvinogona kunge zvine mafirita, zvinowedzera, kana zvinosvibisa zvinogona kuderedza kushanda kwazvo kana kuisa njodzi pahutano. Paunenge uchisarudza iyo AKG magnesium yekuwedzera, tsvaga zvigadzirwa zvakaedzwa zvechitatu-bato kuchena uye mhando. Certification kubva kumasangano akadai seNSF International kana United States Pharmacopeia inova nechokwadi chekuti zvigadzirwa zvinosangana nemhando yepamusoro.
4. Mukurumbira wechiratidzo
Mukurumbira weBrand zvakare unobata basa rakakosha mumhando yezvekuwedzera. Zvigadzirwa zvinonyatsozivikanwa zvine nhoroondo yekugadzira zvigadzirwa zvemhando yepamusoro zvinowanzovimbika kupfuura makambani matsva kana mashoma anozivikanwa. Tsvagurudza ongororo yevatengi uye zviyero kuti uone kushanda uye kuvimbika kwezvigadzirwa zvemhando yako.
5. Chinangwa chekushandisa
Paunosarudza iyo AKG magnesium yekuwedzera, funga nezve yako chaiyo hutano zvinangwa. Uri kutsvaga kusimudzira kuita kwemitambo, kutsigira tsandanyama kupora kana kuvandudza hutano hwese? Magadzirirwo akasiyana anogona kuve akakodzera zvirinani kune zvakasiyana zvinangwa.
Mukudya kwemazuva ano uye kutsvagisa kwebiomedical, α-ketoglutarate magnesium poda yakakwezva kutarisisa kwakawanda sechinhu chakakosha chekudya chinowedzera mbishi. Haisi kungoita basa rinokosha musimba metabolism, inofungidzirwawo kuva nemigumisiro yakanaka pakukura kwesero, kugadzirisa uye kurwisana nekukwegura. Kuti usangane nezvinodiwa zvekutsvagisa kwesainzi uye misika yekuwedzera hutano, zvinonyanya kukosha kusarudza yepamusoro-mhando Alpha Ketoglutarate Magnesium Powder.
Suzhou Myland ibhizimusi rine hunyanzvi mukutsvagisa, kusimudzira uye kugadzirwa kwechikafu chekuwedzera mbishi zvinhu. Yakazvipira kupa vatengi nepamusoro-kuchena α-ketoglutarate magnesium poda. Nhamba yeCAS yechigadzirwa ichi 42083-41-0, uye kuchena kwayo kwakakwira se98%, kuve nechokwadi chekuvimbika kwayo uye kushanda kwayo mukuedza kwakasiyana uye mashandisiro.
Features
Kuchena kwepamusoro: Kuchena kweSuzhou Myland α-ketoglutarate magnesium poda inosvika 98%, zvinoreva kuti vashandisi vanogona kuwana mhinduro dzakarurama uye dzinoenderana dzekuyedza panguva yekushandisa. Zvigadzirwa zvepamusoro-soro zvinogona kuderedza kupindira kwekusvibiswa pakuedza uye kuve nechokwadi chekuoma kwekutsvakurudza.
Hunhu Husimbiso: Sekambani yebiotechnology ine ruzivo rwakapfuma, Suzhou Myland inoteedzera zvimiro zvepasi rose zvekugadzira uye kutonga kwemhando. Imwe neimwe batch yezvigadzirwa inoedzwa kwakasimba kuti ive nechokwadi chekuti inosangana nemhando yakakodzera zviyero. Vatengi vanogona kuishandisa nechivimbo uye kuderedza njodzi dzinokonzerwa nematambudziko emhando yechigadzirwa.
Multiple mabasa: Magnesium α-ketoglutarate powder haisi kungoita basa rinokosha musimba remetabolism, asi rinoshandiswawo zvakanyanya mumitambo yekudya, kurwisa-kukwegura, kuchengetedzwa kwemasero uye mamwe minda. Tsvagiridzo inoratidza kuti AKG inogona kusimudzira kuumbwa kweamino acids, kuwedzera mhasuru kudzoreredza kugona, uye kunonoka kuchembera kusvika pamwero wakati.
Zviri nyore kutora: Semaminerari akakosha, magnesium yakakosha kune akawanda physiological mabasa emuviri wemunhu. Kana yakasanganiswa nealpha-ketoglutarate, iyo bioavailability ye magnesium inowedzera, ichibvumira vashandisi kuwedzera magnesium ivo vachikohwa akawanda mabhenefiti eAKG.
Tenga nzira
Suzhou Myland inopa nyore online kutenga nzira. Vatengi vanogona kuwana nzwisiso yakadzama kuburikidza neiyo yepamutemo webhusaiti. Pamusoro pezvo, timu yehunyanzvi yekambani ichapawo vatengi rutsigiro rwehunyanzvi uye masevhisi ekubvunzana kubatsira vatengi kunzwisisa uye kushandisa zvigadzirwa.
Paunenge uchitsvaga yemhando yepamusoro magnesium alpha-ketoglutarate poda, Suzhou Myland hapana mubvunzo sarudzo yakavimbika. Nekuchena kwayo kwepamusoro, kusimba kwehutongi hwemhando uye tarisiro yakakura yekushandisa, zvigadzirwa zveSuzhou Myland zvinogona kusangana nezvinodiwa zvakasiyana zvevaongorori vesainzi nemabhizinesi. Kunyangwe iwe uri kuita tsvakiridzo yekutanga kana kugadzira zvigadzirwa zvitsva, unogona kuwana kuchengetedzwa kwemhando yepamusoro nerutsigiro nekusarudza Suzhou Myland magnesium alpha-ketoglutarate poda.
Mubvunzo: Chii chinonzi Magnesium Alpha-Ketoglutarate Powder?
A: Magnesium Alpha-Ketoglutarate Powder is a dietary supplement iyo inobatanidza magnesium ne alpha-ketoglutarate, musanganiswa unobatanidzwa muKrebs cycle, iyo yakakosha pakugadzirwa kwesimba mumuviri. Ichi chekuwedzera chinowanzoshandiswa kutsigira hutano hwemetabolism, kusimudzira kuita kwemitambo, uye kukurudzira kugara zvakanaka.
Mubvunzo: Ndezvipi zvakanakira kutora Magnesium Alpha-Ketoglutarate Powder?
A:Mamwe mabhenefiti eMagnesium Alpha-Ketoglutarate Powder anosanganisira:
● Kuwedzerwa Simba Kugadzirwa: Inotsigira Krebs cycle, inobatsira mukushandurwa kwezvokudya kuva simba.
● Kudzoreredzwa Kwetsandanyama: Inogona kubatsira kuderedza kurwadza kwetsandanyama uye kuvandudza nguva yekupora mushure mekurovedza muviri.
● Utano Hwemapfupa: Magnesium inokosha pakuchengetedza mapfupa ane utano uye inogona kubatsira kudzivirira osteoporosis.
Basa rekuziva: Zvimwe zvidzidzo zvinoratidza kuti inogona kutsigira hutano hwehuropi uye basa rekuziva.
● Metabolic Support: Inogona kubatsira mukugadzirisa maitiro emagetsi uye inogona kubatsira nekugadzirisa uremu.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Oct-12-2024
