Urolithin A yakasikwa metabolite inogadzirwa kana muviri uchigaya mamwe makomisheni mumichero yakaita semapomegranati, sitirobheri, uye raspberries. Iyi metabolite yakaratidzwa kuva nehuwandu hwehutano hwehutano uye zvakare inovimbisa anti-kuchembera komboni ine mukana wekuchinja nzira yatinobata nayo nekuchembera. Kugona kwayo kutsigira mitochondrial basa, hutano hwemhasuru, uye kugona kwekuziva kunoita kuti ive inomanikidza yekuwedzera kune avo vari kutsvaga kuchengetedza hudiki uye simba. Sezvo tsvagiridzo yeurolithin A iri kuramba ichishanduka, ingangove musimboti wekupindira mune remangwana rekurwisa kuchembera. Ramba wakatarira iyi komboni ine simba—ingava kiyi yokuzarura chitubu choupwere.
Urolithin A is metabolite inogadzirwa mumatumbo mushure mekudya zvimwe zvekudya, senge mapomegraneti, ellagitannin-ine michero, uye nzungu. Tsvagiridzo inoratidza kuti urolithin A ine masimba ekurwisa kuchembera uye inogona kuita basa rakakosha mukusimudzira hutano hweserura uye hupenyu hurefu.
Urolithin A inoshandisa nzira inonzi mitophagy. Mitophagy inzira yemusikirwo yemuviri yekubvisa yakakuvara kana kusashanda mitochondria, masimba emasero. Sezvo isu tichikura, mitochondria yedu inoita shoma uye inounganidza kukuvadzwa, zvichiita kuti kuderedzwa kwesero kushanda uye hutano hwese. Nekusimudzira mitophagy, urolithin A inobatsira kudzoreredza uye kuzadza mafekitori edu emagetsi emagetsi, zvichigona kunonoka kuchembera.
Pamusoro pekusimudzira hutano hwemitochondrial, urolithin A inewo antioxidant uye anti-inflammatory properties. Oxidative kusagadzikana uye kusingaperi kuzvimba ndiwo maviri akakosha madhiraivha ekuchembera uye ane hukama nezvirwere. Urolithin A inobatsira kurwisa maitiro aya, kudzivirira masero edu uye matishu kubva mukupfeka uye kubvaruka kwekuchembera.
Mukuwedzera, urolithin A yakaratidzwa kuwedzera kushanda kwemhasuru uye kukurudzira hutano hwetsandanyama, iyo inova yakakosha zvikuru patinenge tichikura. Sarcopenia, kana kurasikirwa kwemhasuru kwakabatana nezera, idambudziko rinowanzoitika kune vakura uye rinogona kutungamirira kukushaya simba uye kuderera kwehupenyu hwese. Nekutsigira tsandanyama basa, urolithin A inogona kubatsira kuchengetedza simba uye kufamba sezvatinokura.
Kutanga, ngatitarisei zvakanyanya kuti chii chinonzi urolithin uye kuti inoshanda sei mumuviri. Urolithins mametabolites anogadzirwa apo matumbu emudumbu anopwanya ellagitannins, anowanikwa mumichero yakaita semapomegranati nemabheri. Iyi nzira yakakosha nekuti urolithin haigone kuwanikwa zvakananga nekudya michero iyi. Kana yangogadzirwa, urolithins inofungidzirwa kuti ine hutano hwakasiyana-siyana, kusanganisira kuvandudza mitochondrial basa (iyo yakakosha pakugadzirwa kwesimba remagetsi) uye kukurudzira hutano hwetsandanyama uye hupenyu hurefu.
Chidzidzo chakabudiswa mupepanhau Nature Metabolism chakawana kuti urolithin A, imwe yemhando dzakadzidzwa dzeurolithin, yakavandudza mhasuru kushanda uye kutsungirira mumakonzo akura. Kuwana uku kuri kuvimbisa nekuti inoratidza kuti urolithin inogona kunge ine mabhenefiti ekuderera kwemhasuru ane chekuita nekuchembera.
Pamusoro pezvinogona kubatsira kune hutano hwemhasuru, urolithin yakadzidzwawo kune yayo inorwisa-kuchembera zvivakwa. Imwe ongororo yakabudiswa mupepanhau Nature Medicine muna 2016 yakaratidza kuti urolithin A inogona kudzorera mitochondria mumasero achembera, nekudaro ichivandudza kushanda kwesero uye zvichigona kuderedza kuchembera.
Imwe yeakajairika mafomu eurolithin A ndeyekuwedzera kwekudya. Izvi zvinowedzera zvinowanzotorwa kubva kune pomegranate yakabudiswa kana ellagic acid uye inotorwa mu capsule fomu. Nekudaro, iyo bioavailability yeurolithin A mufomu yekuwedzera inogona kusiyana, uye dzimwe ongororo dzinoratidza kuti inogona kusashanda pane mamwe mafomu.
Imwe fomu yeurolithin A yakafanana nechikafu chinoshanda. Mamwe makambani atanga kuwedzera urolithin A kune zvakasiyana siyana zvekudya uye zvinwiwa zvigadzirwa, senge maprotein bars, zvinwiwa nehupfu. Izvi zvigadzirwa zvinopa nzira iri nyore uye inonaka yekushandisa urolithin A.
Imwe yeanonyanya kuvimbisa mafomu eurolithin A senge yemishonga-giredhi yekuwedzera. Izvi zvigadzirwa zvinoedzwa kwakasimba uye kutonga kwemhando kuti ive nechokwadi chekuchena uye potency. Pharmaceutical giredhi urolithin A inopa yakanyanya bioavailability uye kushanda, zvichiita kuti ive fomu yakanakisa yekuwana iyo inogona kuve hutano mabhenefiti emukomboni uyu.
Mukuwedzera kune mafomu aya, tsvakurudzo iri kuenderera mberi mukugadzirwa kweurolithin A analogues, ayo ari maumbirwo emagetsi akagadzirirwa kutevedzera zvinokonzerwa neurolithin A. Aya mafananidziro anogona kupa zvikomborero zvakasiyana maererano ne bioavailability, kugadzikana, uye potency.
1. Anti-kuchembera zvinhu
Mitochondria ndiwo masimba emasero edu, ane basa rekugadzira simba uye kudzora maserura maitiro. Sezvatinokura, mitochondria yedu inoita shoma, zvichiita kuti basa rose remasero ridzikire. Urolithin A yakaratidzwa kuvandudza mitochondria yekuchembera, nekudaro ichivandudza kugadzirwa kwesimba uye hutano hwesero. Pamusoro pemabhenefiti ayo pamitochondria, urolithin A yakawanikwa kuti ivhure chirongwa chinonzi autophagy. Autophagy ndiyo nzira yemuviri yechisikigo yekubvisa akakuvara kana kusashanda maseru, nekudaro kusimudzira kuvandudzwa kwesero uye hutano hwese. Nekusimudzira autophagy, Urolithin A inobatsira kubvisa masero ekare, akasakara kubva mumuviri uye kuatsiva nemasero matsva, ane hutano, nokudaro achivandudza kushanda kwetishu uye simba rose.
2. Anti-inflammatory properties
Kuzvimba kusingaperi uye kushushikana kweiyo oxidative ndizvo zvinokonzeresa kuchembera, zvichitungamira kune akatevedzana ezvirwere zvine chekuita nezera. Nekudzikisa kuzvimba uye oxidative kusagadzikana, urolithin A inogona kutadzisa kugadzirwa kwemamorekuru anopisa uye kubatsira kudzivirira izvi zvirwere zvine chekuita nezera. chirwere, uye inosimudzira hutano hwese uye hupenyu hurefu.
3. Utano hwetsandanyama
Urolithin A yakawanikwa zvakare kukurudzira hutano hwemhasuru uye basa. Patinokura, mhasuru dzedu nesimba zvinodzikira. Nekudaro, urolithin A inogona kuwedzera tsandanyama sero kuchinja uye kunatsiridza mhasuru mashandiro, izvo zvinogona kubatsira kunonoka kuderera kwemhasuru ine zera.
4. Hutano Hwematumbu
Tsvagiridzo nyowani inoratidza kuti urolithin A inogona kuita basa mukusimudzira hutano hwematumbo. Yakawanikwa iine prebiotic mhedzisiro, zvichireva kuti inotsigira kukura kwemabhakitiriya akanaka mumatumbo. A hutano gut microbiome yakakosha kuhutano hwese, sezvo ichigona kukanganisa zvese kubva mukugaya kusvika kune immune function.
5. Utano hwepfungwa
Pane zvakare humbowo hwekuti urolithin A inogona kuve nemhedzisiro yakanaka pahutano hwekuziva. Tsvagiridzo inoratidza kuti inogona kubatsira kudzivirira zvirwere zveurourodegenerative senge Alzheimer's nekudzikisa kuunganidzwa kwemapuroteni anokuvadza muuropi. Izvi zvinoratidza zvinogona kubatsira kune hutano hwehuropi uye kugona kwekuziva.
Nemhodzi dzayo dzeruby-tsvuku uye tart flavour, mapomegranati anokosheswa nekuda kwehutano hwavo hwakawanda. Kubva pane yakakwira antioxidant yemukati kune yayo inogona anti-kuzvimba zvivakwa, chibereko ichi chakagara chichionekwa sechinhu chine simba munyika ine hutano. Imwe yemakomisheni anonakidza anowanikwa mumapomegranati ndeye urolithin, metabolite yanga iri nyaya yezvidzidzo zvakawanda kune yayo inogona kusimudzira hutano.
Kuti unzwisise mhinduro yemubvunzo uyu, zvakakosha kunyura mukati mesainzi kuseri kweurolithins uye kuti inoumbwa sei. Patinodya chikafu chakapfuma mu ellagitannins, senge mapomegranati, makomisheni aya akaputswa kuita urolithins negut microbiota yedu. Nekudaro, havasi vese vane yakafanana gut microbiota kuumbwa, zvichitungamira kune mutsauko mukugadzirwa kweurolithin pakati pevanhu.
Kunyangwe mapomegranati ari sosi yakapfuma ye ellagitannins, huwandu hweurolithin hwakaumbwa mumuviri hunogona kusiyana. Kusiyana uku kwakakonzera kugadzirwa kweurolithin yekuwedzera inotorwa kubva mupomegranate yakatorwa, kuve nechokwadi chekuenderera mberi kwekudya kweiyi inobatsira metabolite. Aya ma supplements ari kuwana tarisiro yekugona kwavo kutsigira hutano hwemhasuru, kuvandudza mitochondrial basa, uye kuwedzera hutano hwese.
Kubuda kwezvekuwedzera urolithin kwamutsa kufarira mukugona kwavo kushandisa mabhenefiti ehutano emapomegraneti pasina kuvimba nekusiyana kwega mukugadzirwa kweurolithin. Kune avo vanogona kusadya mapomegranati nguva dzose kana kuti vangasabatsirika zvizere kubva kune urolithin yemukati nekuda kwekuumbwa kwe gut microbiota yavo.
Mubvunzo wekuti pomegranate yakatorwa ine urolithins inogona kupindurwa mune affirmative. Kunyangwe urolithin iri yakasikwa yakagadzirwa nemapomegranati, kusiyanisa mukugadzirwa kwayo mumuviri kwakakurudzira kuvandudzwa kweurolithin yekuwedzera kuti ive nechokwadi chekuenderera mberi kwekudya kweiyi inobatsira metabolite.
Sezvo tsvagiridzo ichiramba ichiburitsa hutano-hunokurudzira mhedzisiro yeurolithins, kushandisa pomegranate yakatorwa sesosi yeiyi koniyuta kune yakakura mukana. Kunyangwe kuburikidza nekudya mapomegraneti ivo pachavo kana kushandisa urolithin zvinowedzera, kushandisa simba reurolithin inzira inovimbisa yekutsigira hutano hwese uye kugara zvakanaka.
Pakusarudza urolithin A yekuwedzera, pane akati wandei akakosha zvinhu zvekufunga. Chekutanga uye chakakosha, zvakakosha kuti uwane mugadziri ane mukurumbira anoshandisa zvemhando yepamusoro zvinhu uye anoteedzera akasimba emhando yekudzora zviyero. Tarisa ma supplements ari wechitatu-bato akaedzwa kuchena uye potency kuona kuti uri kuwana yakachengeteka uye inoshanda chigadzirwa.
Uyezve, funga nezve fomu yeurolithin A inoshandiswa mukuwedzera. Urolithin A inowanzosanganiswa nemamwe macompounds, akadai seurolithin B kana ellagic acid, iyo inogona kuwedzera mhedzisiro yayo. Tarisa ma supplements anoshandisa bioavailable fomu yeurolithin A kuti iwedzere kutora kwayo uye kushanda kwayo mumuviri.
Chekupedzisira, funga nezvehutano hwako pachako zvido uye zvinangwa zvako zvekutora urolithin A yekuwedzera. Semuenzaniso, kana iwe uri mumhanyi ari kutsvaga kuvandudza tsandanyama basa, unogona kusarudza yekuwedzera yakanyatso kugadzirirwa hutano hwemhasuru uye kupora.
Suzhou Myland Pharm & Nutrition Inc. yave ichiita bhizinesi rekuwedzera chikafu kubva muna 1992. Ndiyo kambani yekutanga muChina kugadzira nekutengesa mhodzi dzemazambiringa.
Iine makore makumi matatu echiitiko uye ichitungamirwa nehunyanzvi hwepamusoro uye yakagadziridzwa zvakanyanya R&D zano, kambani yakagadzira mhando yezvigadzirwa zvemakwikwi uye ikava yekuvandudza hupenyu hwesainzi yekuwedzera, yetsika synthesis uye kambani yekugadzira masevhisi.
Pamusoro pezvo, kambani iyi zvakare FDA-yakanyoreswa mugadziri, inovimbisa hutano hwevanhu nemhando yakagadzikana uye kukura kwakasimba. Zviwanikwa zvekambani zveR&D uye zvivakwa zvekugadzira uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinokwanisa kugadzira makemikari pamilligram kusvika toni sikero zvichiteerana neISO 9001 zviyero uye GMP maitiro ekugadzira.
Mubvunzo: Chii chinonzi ketone ester uye inoshanda sei?
A: Ketone ester ndeyekuwedzera inopa muviri neketoni, iyo inogadzirwa zvakasikwa nechiropa panguva yekutsanya kana kuderera kwecarbohydrate. Kana ikabatwa, ketone ester inogona kukurumidza kusimudza mazinga eketone yeropa, ichipa muviri kune imwe nzvimbo yemafuta kune glucose.
Mubvunzo: Ndingaisa sei ketone ester muhupenyu hwangu hwezuva nezuva?
A: Ketone ester inogona kuiswa muhutano hwako hwezuva nezuva nekuitora mangwanani sechigadziro chekutanga chekushanda, kuishandisa kuti uwedzere kushanda kwepfungwa uye kuisa pfungwa panguva yebasa kana zvidzidzo zvekudzidza, kana kuipedza sechibatsiro chekudzorera shure kwekushanda. Inogonawo kushandiswa sechishandiso chekushandura mukudya kwe ketogenic kana kutsanya kwepakati.
Mubvunzo: Pane here mhedzisiro kana zvidziviriro zvekufunga kana uchishandisa ketone ester?
A: Kunyange zvazvo ketone ester inowanzoonekwa yakachengeteka kune vanhu vakawanda, vamwe vanhu vanogona kusangana nekusagadzikana kwepamuviri pavanotanga kuishandisa. Zvakakoshawo kubvunzana nenyanzvi yezvehutano usati waisa ketone ester mumuitiro wako, kunyanya kana uine chero mamiriro ezvinhu ehutano huri pasi kana uri kutora mishonga.
Mubvunzo: Ndingaita sei kuti ndiwedzere migumisiro yekushandisa ketone ester?
A: Kuti uwedzere migumisiro yekushandisa ketone ester, zvakakosha kubatanidza kushandiswa kwayo nemararamiro ane hutano anosanganisira nguva dzose kurovedza muviri, hydration yakakwana, uye kudya kwakakwana. Pamusoro pezvo, kutarisisa kunguva yekushandiswa kweketone ester zvine chekuita nemabasa ako nezvinangwa zvinogona kubatsira kukwirisa mhedzisiro yayo.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Jan-15-2024
