Urolithin A imakemikari echisikigo ari mishonga inogadzirwa nemabhakitiriya emudumbu ayo anoshandura ellagitannins kuti ivandudze hutano padanho remasero. Urolithin B yakwezva kutariswa nevaongorori nekuda kwekugona kwayo kuvandudza hutano hwemudumbu nekuderedza kuzvimba. Urolithin A ne urolithin B zvine hunhu hwakabatana, asi zvine musiyano wakasiyana. Ndezvipi musiyano chaiwo, ngatizvionei!
Mumakore achangopfuura, masayendisiti anga achidzidza nezvekubatsira kweurolithin pahutano, chinhu chechisikigo chiri chinhu chinogadzirwa nekushandurwa kweellagitannins nemabhakitiriya emudumbu. Zvinotangira iellagic acid neellagitannins, zvinowanikwa zvakasikwa mune zvekudya zvakasiyana-siyana zvakaita sepomegranate, guava, tii, pecans, nzungu, uye michero senge mastrawberry, mablack raspberries, uye mablackberries. Pamusoro pezvo, urolithin A, polyphenol yechisikigo, inonyanya kufarirwa semushonga une simba rekudzivirira muviri uye unodzivirira kuzvimba une mabhenefiti akanaka pahutano.
Szvidzidzo zviri kuferefeta thMigumisiro yeUA pamabasa emasero uye nzira dzehupenyu yakaratidza kuti ine nzira dzakawanda dzekuita. Zvidzidzo zvakawanawo kuti UA inomutsa mitochondrial autophagy, nzira inobvisa mitochondria yakakuvara kubva musero uye inowedzera kugadzirwa kwesimba. Chiito ichi chinonyanya kukosha kuzvirwere zvine chekuita nekukwegura, sezvo mitochondria isina kushanda zvakanaka inotungamira mukuunganidzwa kwe oxidative stress uye kuzvimba. UA inotongawo kutaurwa kwemajini anobatanidzwa mukupindura kwe oxidative stress, kugadzirisa DNA uye apoptosis, izvo zvakakosha pakuchengetedza masero akasimba uye kudzivirira kenza.
ImwezveChinhu chinonakidza cheUA ndechekutikugona kwayo semushonga wekuchembera, zvinoreva kuti inogona kukonzera apoptosis mumasero ekuchembera, ayo ari masero akakuvara asingachaparadzani asi anoburitsa zvinhu zvinokuvadza zvinokuvadza masero nematishu ari pedyo. Masero ekuchembera anobatanidzwa nezvirwere zvakasiyana-siyana zvine chekuita nekukwegura, zvakaita searthritis, atherosclerosis uye neKubviswa kwemasero aya netsaona. Nekubvisa masero aya, UA inogona kunonotsa kana kudzivirira kutanga kwezvirwere izvi uye kuvandudza hutano hwese.
MaUrolithin iboka remakemikari anozivikanwa se ellagitannin metabolites, ayo anonyanya kugadzirwa ne gut microbiota. Pakati pawo, mamorekuru maviri, urolithin A ne urolithin B, anyanya kutariswa nekuda kwekubatsira kwawo pahutano. Makemikoro aya anowanikwa mumichero yakasiyana-siyana yakaita semapomegranate, mastrawberry, nema raspberries. Mublog rino, tichanyatsoongorora hunhu hune chekuita ne urolithin A ne urolithin B.
Urolithin A ndiyo molekyuru yakawanda kwazvo yemhuri ye urolithin, uye yakatsvakurudzwa zvakanaka nekuda kwesimba rayo rekudzivirira muviri uye rekudzivirira kuzvimba. Uyezve, zvidzidzo zvakaratidza kuti UA inogona kuvandudza mashandiro e mitochondrial nekudzivirira kukuvara kwetsandanyama. UA inozivikanwawo nekuda kwesimba rayo rekudzivirira kenza. Tsvagiridzo yakaratidza kuti UA inogona kudzivirira kuwanda kwemasero uye kukonzera kufa kwemasero mumasero akasiyana-siyana ekenza, kusanganisira masero ekenza yeprostate, yezamu, uye yeura.
Kune rumwe rutivi, urolithin B yakwezva vaongorori nekuda kwekugona kwayo kuvandudza hutano hwematumbu nekuderedza kuzvimba. Zvidzidzo zvakaratidza kuti UB inogona kuwedzera kusiyana kwehutachiona mudumbu uye kuderedza ma cytokines anokonzera kuzvimba, akadai se interleukin-6 uye tumor necrosis factor-alpha. Uyezve, UB yakawanikwawo kuti ine simba rekudzivirira tsinga, sezvo zvidzidzo zvakaratidza kuti inogona kubatsira kudzivirira zvirwere zvinoderedza tsinga zvakaita seParkinson's neAlzheimer's.
Pasinei nehukama hwazvo, UA neUB zvine musiyano mukuru. Semuenzaniso, UA yakaratidzwa kuva ine simba rekudzivirira kuzvimba uye antioxidant kupfuura UB. Kune rumwe rutivi, UB yakaonekwa ichishanda zvakanyanya mukudzivirira matambudziko ane chekuita nekufuta, akadai sekusakwanisa insulin uye kusiyana kwemafuta. Pamusoro pezvo, kusiyana neUA, UB haina kudzidzwa zvakanyanya semushonga wekurwisa kenza.
Maitiro ekushanda kweUA neUB akasiyanawo. UA inomutsa nzira yePeroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), iyo inoita basa mu mitochondrial biogenesis, ukuwo UB ichivandudza nzira yeAMP-activated protein kinase (AMPK), iyo inobatanidzwa mu energy homeostasis. Nzira idzi dzinobatsira mukubatsira kwemakemikari aya pahutano.
Pasinei nemabhenefiti anofadza eUA neUB, kuchine zvipingamupinyi pakushandiswa kwazvo. Semuenzaniso, kuwanikwa kwezvinhu izvi kuchiri kushoma, uye pharmacokinetics yazvo haisati yanyatsonzwisiswa. Uyezve, mhedzisiro yemakemikari aya pavanhu haisati yanyatsojekeswa, sezvo zvidzidzo zvakawanda zvakaitwa mu vitro kana mumhando dzemhuka. Kunyange zvakadaro, tsvakiridzo iripo inoratidza kuti UA neUB zvinogona kuva vanhu vane tariro yekugadzira chikafu chinoshanda kana zvinowedzera simba rekutsigira hutano hwese nekudzivirira zvirwere.
Urolithin A. Kamorekuru aka kadiki kanowanikwa mumichero nenzungu kanozivikanwa nekuda kwekugona kwaro kuvandudza zvese kubva pakukura kwetsandanyama kusvika pakushanda kwehuropi. Urolithin A imusanganiswa wemetabolite, zvinoreva kuti ichibereko chemamwe macompounds mumuviri. Kunyanya, inogadzirwa kana mabhakitiriya emudumbu achipwanya ellagitannins, anowanikwa mune zvimwe zvekudya zvakaita semapomegranate, mastrawberry nemawalnuts. Asi heino chikamu chinonakidza: havasi vese vane mabhakitiriya emudumbu anodiwa kuti agadzire urolithin A. Kutaura zvazviri, zvidzidzo zvakaratidza kuti vanhu vanosvika 30-50% chete ndivo vanogona kugadzira molekyulu iyi zvakasikwa. Apa ndipo panobatsira zvekudya zvinovaka muviri.
Saka, chii chiriMabhenefiti eurolithin A? Chimwe chezvinhu zvikuru chinotaurwa ndechekuti inogona kubatsira kuvandudza hutano hwetsandanyama. Chidzidzo chakaburitswa mujenari reNature Medicine chakaona kuti makonzo paakapihwa urolithin A, akawedzera kutsungirira ne42% uye akawedzera ne70% mutsandanyama. Kunyange zvazvo mhedzisiro iyi ichishamisa, zvakakosha kuziva kuti iyi yaive ongororo diki uye kutsvagurudza kwakawanda kunodiwa kusimbisa zvakawanikwa izvi muvanhu.
Asi handizvo chete zvinonzi urolithin A inoita. Zvakaratidzwawo kuti inovandudza mashandiro emitochondrial. Mitochondria ndiyo nzvimbo dzinoshandiswa nemasero, dzinoita basa rekugadzira simba rinogona kushandiswa nemuviri. Sezvatinokura, mashandiro edu emitochondrial anotanga kudzikira, izvo zvinogona kukonzera matambudziko mazhinji ehutano. Zvisinei, tsvakiridzo yekutanga inoratidza kuti urolithin A inogona kubatsira kunonoka kudzikira uku, zvichigona kuvandudza hutano hwese uye kuwedzera nguva yekurarama.
Sekunge izvozvo hazvina kukwana, urolithin A yakaratidzwawo kuti ine mabhenefiti ekuziva. Ongororo yakaburitswa mujenari reScientific Reports yakawana kuti makonzo paakapihwa urolithin A, kugona kwawo kurangarira nekudzidza kwakawedzera. Vaongorori vanotenda kuti izvi zvinogona kunge zvichikonzerwa nemhedzisiro yemorekuru iyi yekurwisa kuzvimba, iyo inobatsira kudzivirira masero europi kubva mukukuvadzwa.
Urolithin B, chinhu chinowanikwa mumabheri akasiyana-siyana nemapomegranate, chinozivikanwa nekugona kwayo kubatsira mukuvandudza hutano hwemuviri uye kuwedzera hupenyu hwemuviri. Ongororo dzichangoburwa dzakaratidza kuti urolithin B ine simba rekudzivirira kuzvimba uye rekudzivirira muviri iro rinogona kubatsira kudzivirira zvirwere zvisingaperi uye kuvandudza hutano hwese.
1. Hunhu hwekudzivirira kuzvimba
Kuzvimba kwenguva refu ndicho chikonzero chikuru chezvirwere zvakawanda, zvinosanganisira chirwere chemwoyo, chirwere cheshuga nekenza. Urolithin B ine simba rekudzivirira kuzvimba rinobatsira kuderedza kuzvimba mumuviri, nokudaro ichideredza njodzi yezvirwere zvisingaperi. Imwe ongororo yakawana kuti urolithin B inoderedza kuzvimba zvakanyanya mumakonzo ane chirwere chekuzvimba kwematumbu, zvichiratidza kuti inogona kushanda zvakanaka mukurapa vanhu vane zvirwere zvakafanana.
2. Hunhu hweAntioxidant
Urolithin B iantioxidant ine simba, zvinoreva kuti inogona kubatsira kudzivirira muviri kubva mukushushikana kwe oxidative, maitiro anokuvadza masero uye anokurudzira kukwegura. Urolithin B inobatsira kudzivirira kukuvara kwe oxidative nekubvisa ma free radicals, ayo anogona kukonzera kukuvara kwemasero uye kutungamira kuzvirwere zvisingaperi. Imwe ongororo yakawana kuti urolithin B inoderedza kushushikana kwe oxidative mumakonzo, ichitsigira kugona kwayo semushonga wekudzivirira kukwegura.
3. Kurudzira hutano hwetsandanyama
Urolithin B yakaratidzwa kuti inokurudzira mitochondrial autophagy, maitiro emasero anobatsira kubvisa mitochondria yakakuvara kubva mumasero. Maitiro aya anobatsira kuvandudza hutano hwetsandanyama nekushanda zvakanaka, zvichiita kuti ive imwe yekuwedzera kune avo vari kutsvaga kuvandudza mashandiro emuviri. Imwe ongororo yakawana kuti urolithin B yakavandudza mashandiro etsandanyama uye simba mumakonzo nevanhu.
4. Inotsigira hutano hwepfungwa
Urolithin B yakaratidzwa kuti inotsigira hutano hwepfungwa nekusimudzira neuroplasticity, nzira inobatsira uropi kuti hugamuchire ruzivo rutsva uye inogona kuvandudza mashandiro epfungwa. Imwe ongororo yakawana kuti urolithin B inovandudza mashandiro epfungwa uye inovandudza ndangariro mumakonzo.
5. Mabhenefiti anogona kuwanikwa kwenguva refu
Ongororo dzichangobva kuitwa dzakaratidza kuti urolithin B ine mukana wekusimudzira hupenyu hurefu nekuvandudza hutano hwemetabolism, kuderedza kuzvimba, uye kudzivirira kubva mukushushikana kwe oxidative. Imwe ongororo yakawana kuti urolithin B inowedzera hupenyu hwemuviri muC. elegans, rudzi rwehonye ye nematode, zvichitsigira mabhenefiti ayo ekusimudzira hupenyu hurefu.
1. Pomegranate
Pomegranate ndeimwe yenzvimbo dzakanakisisa dzinopa urolithin. Vaongorori vakaona kuti muto wepomegranate unogona kuwedzera huwandu hweurolithin A neB muropa. Pamusoro pezvo, mapomegranate ane zvimwe zvakanakira pahutano, zvinosanganisira kudzivirira kuzvimba uye antioxidant properties.
2. Mabheri
Mabheri akadai semastrawberry, maraspberry nemablackberries ndiwo manyuko akanaka eurolithin. Ongororo dzakaratidza kuti kudya mabheri kunogona kuwedzera huwandu hweurolithin A neB muropa.
3. Nzungu
Nzungu dzeWalnuts, pecans nedzimwe nzunguwo dzinopawo urolithin. Ongororo yakawana kuti kudya nzungu kunowedzera huwandu hweurolithin A neB muropa.
Urolithin A naB zvinhu zvakasikwa zvinowanikwa mune zvimwe zvekudya, zvine mabhenefiti akawanda pahutano. Zvinhu izvi zvine simba rekudzivirira kuzvimba, zvinovandudza hutano hwemitochondrial netsandanyama, uye zvinosimudzira hutano hwepfungwa. Mapomegranate, michero, nzungu uye ellagitannin zvinowedzera ndezvimwe zvezvikafu zvakanakisa zvinogona kupa urolithin. Kuisa zvekudya izvi mukudya kwako kunogona kukubatsira kuona mabhenefiti eurolithin A naB uye kukurudzira kukwegura kwakanaka.
Nguva yekutumira: Chikumi-05-2023
