Urolithin A ndiwo masikirwo emakomisheni ayo ari metabolite makomisheni anogadzirwa nemabhakitiriya emudumbu anoshandura ellagitannins kuti avandudze hutano padanho remasero. Urolithin B yakawana kutariswa kwevaongorori nekuda kwekugona kwayo kuvandudza hutano hwematumbo uye kuderedza kuzvimba. Urolithin A uye urolithin B ane hukama, asi ane mimwe misiyano yakasiyana. Ndeipi misiyano chaiyo iwe, ngationei!
Mumakore achangopfuura, masayendisiti anga achidzidza nezvehutano hunobatsira hweurolithin, musanganiswa wechisikigo uri musanganiswa wemetabolite unogadzirwa nekushandurwa kwe ellagitannins nemabhakitiriya emudumbu. Magadzirirwo ayo ellagic asidhi uye ellagitannins, izvo zvinowanzoitika mune zvakati wandei zvekudya zvakaita sepomegranate, guava, tii, pecans, nzungu, uye michero yakaita sestrawberries, black raspberries, uye blackberries. Mukuwedzera, urolithin A, polyphenol yakasikwa, inofarira seine simba antioxidant uye anti-inflammatory agent ine hutano hwakanaka hunobatsira.
Sdzidzo dziri kuongorora the mhedzisiro yeUA pane cellular mabasa uye biological nzira dzakaratidza kuti ine akawanda maitiro ekuita. Zvidzidzo zvakawanawo kuti UA inomisikidza mitochondrial autophagy, maitiro anobvisa yakakuvadzwa mitochondria kubva muchitokisi uye inowedzera kugadzirwa kwesimba. Ichi chiito chinonyanya kukosha kune zvirwere zvine chokuita nekukwegura, sezvo mitochondria isingashande inotungamirira kukuunganidza kwekunetseka kweoxidative uye kuzvimba. UA inogadzirisawo kutaura kwemajini ane chekuita neoxidative kusagadzikana mhinduro, kugadzirisa kweDNA uye apoptosis, izvo zvakakosha pakuchengetedza kuvimbika kweserura uye kudzivirira cancer.
Another inonakidza chikamu cheUA ndeyesimba rayo se senescence scavenger, izvo zvinoreva kuti inogona kusarudza kupinza apoptosis mumasero ane senescent, ayo akakuvadzwa masero ayo haachapatsanuri asi anoburitsa zvinokuvadza zvinokuvadza masero nematishu akavakidzana. Senescent masero anosanganiswa nezvirwere zvakasiyana-siyana zvine chekuita nekuchembera, senge arthritis, atherosclerosis uye neurodegeneration. Nekusarudza kubvisa maseru aya, UA inogona kunonoka kana kudzivirira kutanga kwezvirwere izvi uye kugadzirisa hutano hwese.
Urolithins ikirasi yemakemikari anozivikanwa se ellagitannin metabolites, ayo anonyanya kugadzirwa negut microbiota. Pakati pawo, mamorekuru maviri, urolithin A uye urolithin B, akawana kutariswa kwakakosha kune kwavo kwakanakira hutano. Mishonga iyi inowanikwa mumichero yakasiyana-siyana yakadai semapomegranati, sitirobheri, uye raspberries. Mune ino blog, isu tichanyatso tarisisa kune inoenderana zvimiro zveurolithin A uye urolithin B.
Urolithin A ndiyo molecule yakawanda kwazvo yemhuri yeurolithin, uye yakanyatso tsvakurudzwa kune yayo antioxidant uye anti-inflammatory properties. Uyezve, zvidzidzo zvakaratidza kuti UA inogona kuvandudza mitochondrial basa uye kudzivirira kukuvara kwemhasuru. UA inozivikanwa zvakare nekugona kwayo anti-gomarara zvivakwa. Tsvagiridzo yakaratidza kuti UA inogona kumisa kuwanda kwesero uye kukonzeresa kufa kwesero mumasero akasiyana ekenza, kusanganisira prostate, zamu, uye colon cancer maseru.
Kune rimwe divi, urolithin B yakawana kutariswa kwevaongorori nekuda kwekugona kwayo kugadzirisa hutano hwematumbu uye kuderedza kuzvimba. Zvidzidzo zvakaratidza kuti UB inogona kuwedzera gut microbial kusiyana uye kuderedza pro-inflammatory cytokines, senge interleukin-6 uye tumor necrosis factor-alpha. Uyezve, UB yakawanikwa zvakare iine zvingangoita neuroprotective zvivakwa, sezvo ongororo dzakaratidza kuti inogona kubatsira kudzivirira neurodegenerative zvirwere zvakaita seParkinson's neAlzheimer's.
Kunyangwe zvivakwa zvadzo zvine hukama, UA neUB vane mimwe misiyano yakakurumbira. Semuyenzaniso, UA yakaratidzwa kuva ine simba zvakanyanya seanorwisa-kuzvimba uye antioxidant agent pane UB. Kune rumwe rutivi, UB yakawanikwa ichinyanya kushanda mukudzivirira kwehutano hwehutano hwakanyanya, zvakadai se insulin resistance uye adipocyte differentiation. Pamusoro pezvo, kusiyana neUA, UB haina kudzidzwa zvakanyanya seanorwisa kenza.
Iyo nzira yekuita yeUA neUB yakasiyana zvakare. UA inomutsa Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) nzira, iyo inobata basa mumitochondrial biogenesis, nepo UB inosimudzira AMP-activated protein kinase (AMPK) nzira, iyo inobatanidzwa musimba homeostasis. Idzi nzira dzinobatsira kune zvinobatsira zvezvisanganiswa izvi pahutano.
Kunyangwe nemabhenefiti anonakidza eUA neUB, pachine zvipimo pakushandisa kwavo. Semuenzaniso, iyo bioavailability yemakomponi aya ichiri yakaderera, uye pharmacokinetics yavo haina kunyatsonzwisiswa. Uyezve, mhedzisiro yemakomponi aya pavanhu haisati yanyatsojekeswa, sezvo ongororo zhinji dzakaitwa in vitro kana mumhando dzemhuka. Zvakadaro, tsvakiridzo iripo inoratidza kuti UA neUB vanogona kunge vari kuvimbisa vakwikwidzi vekugadzira chikafu chinoshanda kana ma supplements kutsigira hutano hwese nekudzivirira chirwere.
Urolithin A. Iri morekuru diki rinowanikwa mune mimwe michero nenzungu rinofarirwa nehunyanzvi hwaro hwekuvandudza zvese kubva pakukura kwetsandanyama kusvika kukushanda kwehuropi. Urolithin A is metabolite, zvinoreva kuti inobuda kubva kune mamwe makomisheni mumuviri. Kunyanya, inogadzirwa apo mabhakitiriya emudumbu anoputsa ellagitannins, ayo anowanikwa mune zvimwe zvekudya zvakadai semapomegranati, sitirobheri uye walnuts. Asi heino chikamu chinonakidza: havasi vose vane gut mabhakitiriya anodiwa kuti abudise urolithin A. Zvechokwadi, zvidzidzo zvakaratidza kuti chete 30-50% yevanhu vanogona kubudisa iyi molecule zvakasikwa. Apa ndipo panouya ma supplements anobatsira.
Saka, chiizvinobatsira zveurolithin A? Zvakanaka, chimwe chezvirevo zvikuru ndechekuti inogona kubatsira kuvandudza hutano hwemhasuru. Chimwe chidzidzo chakabudiswa mumagazini inonzi Nature Medicine chakawana kuti apo makonzo akapiwa urolithin A, aiva ne42% kuwedzera kwekutsungirira uye 70% kuwedzera kwemhasuru. Kunyange mhedzisiro iyi ichinakidza, zvakakosha kuziva kuti ichi chaive chidzidzo chidiki uye tsvakiridzo yakawanda inodiwa kusimbisa zvakawanikwa izvi muvanhu.
Asi handizvo chete izvo urolithin A inonzi iite. Yakaratidzawo kuvandudza mitochondrial basa. Mitochondria ndiwo mashizha emagetsi emaseru, ane basa rekugadzira simba iro muviri unogona kushandisa. Sezvatinokura, basa redu remitochondrial rinotanga kuderera, izvo zvinogona kutungamirira kumatambudziko akawanda ehutano. Nekudaro, tsvagiridzo yepakutanga inoratidza kuti urolithin A inogona kubatsira kudzikira uku, zvichigona kuvandudza hutano hwese uye kuwedzera hupenyu hwehupenyu.
Sokunge izvo zvisina kukwana, urolithin A yakaratidzawo kuva neruzivo rwekuziva. Imwe ongororo yakabudiswa mupepanhau Scientific Reports yakawana kuti apo makonzo akapiwa urolithin A, ndangariro dzavo uye kugona kudzidza zvakavandudzika. Vatsvagiri vanotenda kuti izvi zvinogona kunge zviri nekuda kwemorekuru rinopesana nekuzvimba mhedzisiro, iyo inobatsira kuchengetedza masero ehuropi kubva mukukuvadzwa.
Urolithin B, komisheni inowanikwa mumhando dzakasiyana-siyana dzemajikijoro nemapomegraneti, inozivikanwa nekugona kwayo kubatsira mukuvandudza hutano hwemetabolism uye kuwedzera hupenyu. Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti urolithin B ine anti-inflammatory uye antioxidant zvinhu zvinogona kubatsira kudzivirira zvirwere zvisingaperi uye kugadzirisa hutano hwese.
1. Anti-inflammatory properties
Chirwere chisingaperi ndicho chikonzero chikuru chezvirwere zvakawanda, kusanganisira chirwere chemwoyo, chirwere cheshuga negomarara. Urolithin B ine anti-inflammatory properties inobatsira kuderedza kuzvimba mumuviri, nokudaro kuderedza ngozi yechirwere chisingaperi. Imwe ongororo yakawana kuti urolithin B yakanyanya kuderedza kuzvimba mumakonzo ane chirwere chinoputika, zvichiratidza kugona kwayo mukurapa vanhu vane zvirwere zvakafanana.
2. Antioxidant properties
Urolithin B ine simba antioxidant, zvinoreva kuti inogona kubatsira kudzivirira muviri kubva kune oxidative kusagadzikana, maitiro anokuvadza masero uye anokurudzira kuchembera. Urolithin B inobatsira kudzivirira kukuvadzwa kweoxidative nekumisa mahara radicals, izvo zvinogona kukonzera kukuvara kweserura uye kutungamirira kuchirwere chisingaperi. Imwe ongororo yakawana kuti urolithin B yakaderedza oxidative kusagadzikana mumakonzo, ichienderera mberi ichitsigira kugona kwayo sekuwedzera kuchembera.
3. Kurudzira hutano hwemhasuru
Urolithin B yakaratidza kukurudzira mitochondrial autophagy, cellular process inobatsira kubvisa yakakuvadzwa mitochondria kubva kumasero. Iyi nzira inobatsira kuvandudza hutano hwemhasuru uye basa, zvichiita kuti ive yekuwedzera kune avo vari kutsvaga kuvandudza kuita kwemuviri. Imwe ongororo yakawana kuti urolithin B inovandudza tsandanyama basa uye simba mumakonzo nevanhu.
4. Inotsigira hutano hwepfungwa
Urolithin B yakaratidzwa kutsigira hutano hwekuziva nekusimudzira neuroplasticity, maitiro anobatsira uropi kujairana neruzivo rutsva uye inogona kuvandudza kugona kwekuziva. Imwe ongororo yakawana kuti urolithin B inovandudza kugona kwekuziva uye inosimudzira ndangariro mumakonzo.
5. Kugona kurarama kwenguva refu kunobatsira
Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti urolithin B ine mukana wekusimudzira hupenyu hurefu nekuvandudza hutano hwemetabolism, kuderedza kuzvimba, nekudzivirira kubva kune oxidative kusagadzikana. Imwe ongororo yakawana kuti urolithin B yakawedzera hupenyu muC. elegans, rudzi rwehonye yenematode, inotsigira zvingangobatsira zvekusimudzira hupenyu hurefu.
1. Damba
Pomegranate ndeimwe yeakanakisa masosi eurolithin. Vatsvakurudzi vakaona kuti pomegranate juice inogona kuwedzera mazinga eropa eurolithins A uye B. Mukuwedzera, mapomegranati ane humwe hutano hunobatsira, kusanganisira anti-inflammatory uye antioxidant properties.
2. Mabheri
Zvibereko zvakadai semastrawberries, raspberries uye mablackberries zvakare akanaka masosi eurolithin. Zvidzidzo zvakaratidza kuti kunwa berry kunogona kuwedzera mazinga eropa eurolithin A uye B.
3. Nzungu
Walnuts uye pecans nedzimwe nzungu zvakare yakanaka sosi yeurolithin. Chidzidzo chakawana kuti kudyiwa kwenzungu kuchawedzera mwero weurolithin A uye B muropa.
Urolithin A uye B masikirwo emakomisheni aripo mune zvimwe zvekudya, ane akawanda mabhenefiti ehutano. Aya makomisheni ane anti-kuzvimba zvivakwa, anovandudza mitochondrial uye tsandanyama hutano, uye anokurudzira hutano hwekuziva. Matamba, majiroji, nzungu uye ellagitannin zvinowedzera ndezvimwe zvezvakanakisa zvekudya zvinogona kupa urolithins. Kusanganisira izvi zvekudya mukudya kwako zvinogona kukubatsira kuvhura mabhenefiti eurolithins A uye B uye kukurudzira kuchembera kune hutano.
Nguva yekutumira: Jun-05-2023
