Spermidine, ane simba activator ye cell renewal process, inowanzoonekwa se "tsime rehudiki." Iyi micronutrient ikemikari polyamine uye inogadzirwa zvakanyanya nemabhakitiriya emudumbu mumiviri yedu. Mukuwedzera, spermidine inogonawo kutorwa nemuviri kuburikidza nekudya kwekudya. Tsvagiridzo inoratidza kuti spermidine, ingave yakapihwa kunze kana kugadzirwa nemuviri wega microbiome, inoshanda nenzira inowirirana.
Concentrations of endogenous spermidine inogona kuderera nezera, uye panogona kuva nekubatana pakati peizvi uye kuderera kwezera-kuora mukushanda kwemuviri. Spermidine inowanikwa mune zvakawanda zvekudya, negrapefruit iri imwe yezvakapfuma zvakanyanya spermidine-rich food. Zvimwe zvidzidzo zvakawana kuti spermidine haingodzikisi kuchembera chete asi inogona kukurudzira hutano uye hupenyu hurefu. Izvi zvakawanikwa zvinoita kuti spermidine ive imwe yemisoro inopisa yekutsvagisa kwazvino.
Muzvisikwa zvipenyu, matishu concentrations yespermidinekuderera nenzira inoenderana nezera; zvisinei, vane hutano 90- uye centenarians vane spermidine mwero pedyo nevaya vaduku (pakati-kati) vanhu. Chidzidzo che epidemiological chakashuma hukama hwakanaka pakati pekudya kwespermidine uye hutano hwevanhu. Vatori vechikamu 829 vane makore 45-84 vakateverwa kwemakore gumi nemashanu. Kudya kweSpermidine kwaifungidzirwa makore ese e5 zvichibva pane yekudya frequency yemibvunzo. Zvidzidzo zvakawana kuti vanhu vane yakakwira spermidine yekudya vakadzikisa mwero wegomarara uye chirwere chemoyo uye vanobatanidzwa nekuvandudzwa kwehupenyu hwese.
◆ Anti-aging mechanism
Muna 2023, "Cell" yakaburitsa chinyorwa chekuti kune gumi nembiri zviratidzo zvekuchembera, zvinosanganisira kusagadzikana kwegenome, telomere attrition, epigenetic shanduko, kurasikirwa kweprotein homeostasis, macroautophagy kusakwanisa, kusagadzikana kwekunzwa kwekudya, mitochondrial dysfunction, uye cellular senescence. Stem cell kuneta, kuchinjika kutaurirana kwepakati, kuzvimba kusingaperi, uye dysbiosis.
● Induction of autophagy
Parizvino, induction ye autophagy inofungidzirwa kuti ndiyo nzira huru iyo spermidine inononoka kukwegura. Zvidzidzo zvakawana kuti spermidine induces dephosphorylation yeprotein kinase B, zvichikonzera kutakurwa kweforkhead box transcription factor O (FoxO) transcription factor kunucleus, zvichikonzera kuwedzera kunyorwa kweFoxO target gene autophagy microtubule-yakabatana protein light chain 3 (LC3). ) Kurudzira autophagy.
Uye zvakare, spermidine yakawanikwa ichibatsira kunonoka kuchembera kwechikadzi masero masero anokonzerwa neoxidative kusagadzikana uye kuchengetedza kubereka kwevakadzi. Chidzidzo chekiriniki chegore rose chakawana kuti chiyero chembeu chakawedzerwa muvazvipiri vevarume vane hutano pavakadyiswa spermidine; Muchidzidzo che2022, chidzidzo chakatarisa kune 377 acute myocardial infarction (AMI) varwere. vakawana kuti vanhu vane mazinga akakwirira espermidine muropa ravo vaiva nemararamiro ari nani ekurarama kupfuura varwere vechirwere chemwoyo vane mazinga akaderera espermidine; a 2021 magazine yakawana kuti kudya kwepamusoro spermidine intake Pane chinongedzo pakati pedosi uye njodzi yakaderedzwa yekusaziva kwekuziva muvanhu, ichibatsira zvakanyanya uropi mukuvandudza cognition nekudzivirira zvakajairika zvirwere zvehuropi zvine chekuita nezera.
●Kunonotsa kuchembera telomere
Kuchembera kunokonzera kuwanda kwema molecular, cellular, uye physiological degeneration, kusanganisira kutadza kwemoyo, neurodegeneration, metabolic maladaptation, telomere attrition, uye kurasikirwa nebvudzi. Sezvineiwo, padanho remamorekuru, kugona kukonzeresa autophagy (iyo huru nzira yekuita kwespermidine) inoderera nezera, chiitiko chiripo mune dzakawanda zvipenyu mhando uye inofungidzirwa kuti yakabatana zvakanyanya nekuchembera. .
●Antioxidant uye anti-inflammatory effects
Oxidative kusagadzikana chinhu chakakosha chinotungamira kuchembera kwesero uye kukuvara. Spermidine ine antioxidant zvinhu. Vatsvakurudzi vakadyisa mbeva exogenous spermidine kwemwedzi mitatu uye vakaona shanduko mumaovari. Mushure mekurapa kwe spermidine, boka, nhamba yeatrophic follicles (yakaora follicles) yakaderedzwa zvakanyanya, antioxidant enzyme basa yakawedzera, uye malondialdehyde (MDA) mazinga akaderera, izvo zvinogona kuderedza reactive oxygen marudzi (ROS) mazinga, zvichiratidza kuderedza oxidative kusagadzikana mu spermidine. -treated group .
Kuzvimba kusingadzivisiki sezvatinokura. Kuwedzera kwe spermidine kunobatsira kukurudzira kugadzirwa kwea-anti-inflammatory cytokines uku ichideredza kugadzirwa kwepro-inflammatory cytokines. Ongororo ichangoburwa inoratidza kuti spermidine inowedzerawo anti-inflammatory properties ye macrophages.
●Dzivisa stem cell kuchembera
Spermidine inosimudzira mitochondrial basa uye keratin kugadzirwa muepithelial stem masero, kuwedzera kuve nechokwadi chemhasuru uye bvudzi follicle kuvandudzwa.
Spermidinemusanganiswa we polyamine unowanikwa muzvisikwa zvipenyu. Sezvo iri polyamine compound, ine akawanda amino (-NH2) mapoka. Aya mapoka anopawo iyo yakasarudzika uye yakakosha Kuravira kwezita.
Izvo chaizvo nekuda kweaya mapoka emaamino ayo anogona kudyidzana neakasiyana mabiomolecules uye kuita mabasa ayo emuviri mukati memasero. Semuenzaniso, inoita basa rakakosha mukukura kwesero, kusiyanisa, kutonga kwemajini, uye kurwisa kuchembera.
Anti kuchembera
Spermidine level chiratidzo chinoratidza chiyero chekukwegura kwemuviri. Sezvo muviri uchikura, iyo spermidine iri mumuviri inodzikirawo. Zvidzidzo zvakaratidza kuti spermidine inogona kunonoka kuchembera kwemasero senge mbiriso maseru uye mammalian masero, uye kuwedzera hupenyu hweinvertebrate modhi zvipenyu zvakaita seDrosophila melanogaster uye Caenorhabditis elegans nemakonzo.
Parizvino, induction ye autophagy yakaratidzwa kuva imwe yenzira huru iyo spermidine inononoka kukwegura uye inowedzera hupenyu. Zvidzidzo zvakaratidza kuti mushure mekugogodza majini akakosha kune autophagy mukuchembera mbiriso, Drosophila uye masero akakura emammalian, mhuka dzemhando idzi hadzina kuwana hupenyu hwakareba mushure mekurapwa nespermidine. Mukuwedzera, spermidine inoshandawo kuburikidza nenzira dzakadai sekuderedza histone acetylation.
Antioxidant
Spermidine ine akakosha antioxidant mabasa, uye inogona kuita yakakura anti-kuchembera mhedzisiro kuburikidza neiyo antioxidant zvimiro. Zvidzidzo zvakaratidza kuti spermidine inogona kuderedza zvakanyanya mazinga eiyo oxidant malondialdehyde uye kuwedzera mazinga eiyo antioxidant yakaderedzwa glutathione muhuropi hwemakonzo.
Spermidine supplementation yakasimbisawo basa re electron transport cheni complexes mu mitochondria yehuropi hwekuchembera, zvichiratidza kugona kwayo kwe antioxidant pazinga remitochondrial. Spermidine inoderedza kukuvadzwa kwetsinga kunokonzerwa nekuchembera-induced oxidative kusagadzikana nekudzora autophagy, antioxidant mazinga uye kuderedza neuroinflammation.
Zvidzidzo zvakawana kuti spermidine inodzivirira H2O2-induced cell damage nekuvhara kuwedzera kweCa2 + mumunhu retinal pigment epithelial cells.
Anti-inflammatory
Spermidine ine unhu hwakanaka hunopesana nekuputika, uye maitiro ayo ane chokuita nekudzivisa kugadzirwa kwezvinhu zvinoputika, kukurudzira kugadzirwa kwezvinhu zvinopesana nekuputika, uye kukanganisa polarization ye macrophages.
Zvidzidzo zvakawana kuti spermidine inogona kuderedza mazinga e-pro-inflammatory zvinhu zvakadai se interleukin 6 uye tumor necrosis factor mu serum yemakonzo ane collagen-induced arthritis, kuwedzera chiyero che IL-10, inhibit polarization yeM1 macrophages mu synovial tissue. , uye kuderedza njodzi yearthritis. Mouse synovial masero akawedzera uye masero ekuputika akapinda mukati, achiratidza zvakanaka anti-inflammatory effects.
Vandudza cognition
Nekukura kwehuwandu hwevanhu, kukanganiswa kwekuziva kwakabatana nezera kuri kuramba kuchinetsa. Spermidine, seye autophagy inducer, yakaratidzwa kuva neyakagwinyisa mhedzisiro pakuderera kwekuziva.
Tsvagiridzo inoratidza kuti mukuchembera nhunzi dzemichero, mazinga espermidine anoderera, izvo zvinoperekedzwa nekuderera kwekugona kurangarira. Spermidine supplementation inodyiswa kunhunzi inoderedza kukanganiswa kwendangariro mukuchembera nhunzi nekudzivisa shanduko yemaitiro uye inoshanda mukuita kwepresynaptic kunokonzerwa nemazinga akakwira e synaptic proteins uye anosunga mapuroteni.
Spermidine mukudya inogona kupfuura nepakati peropa-uropi chinovharira mbeva, kuwedzera mitochondrial kufema mumbeva neuron tishu, uye kugadzirisa yekuziva basa rembeva. Pahwaro hwekuedza kwemhuka, zvimwe zvidzidzo zvevanhu zvakaratidzawo kuti spermidine ine hukama hwepedyo nekuziva.
Chengetedza mwoyo
Spermidine inogona kuchengetedza hutano hwemwoyo uye ine mhedzisiro yakawanda sekudzivirira kuchembera kwemoyo, kuderedza kukwira kweropa uye kunonoka kutadza kwemoyo. Zvidzidzo zvakaratidza kuti spermidine supplementation inogona kuwedzera cardiac autophagy uye mitophagy mumakonzo, kuita cardioprotective mhedzisiro uye kunonoka kuchembera kwemoyo.
Mumakonzo akwegura, kudya kwe spermidine supplementation kunovandudza mechanical elasticity uye metabolic properties ye cardiomyocytes, nokudaro kuwedzera hupenyu uye kudzivirira zera-induced cardiac hypertrophy uye kuoma. Zvidzidzo zveEpidemiological muvanhu zvinoratidza kuti spermidine ine zvidziviriro zvakafanana pahutano hwemoyo wemunhu. Spermidine yekudya mukudya kwevanhu inopesana nehurwere hwemwoyo. Izvi zvimiro zvespermidine zvinovhura nzira nyowani dzekurapa zvirwere zvemoyo.
Ikozvino mamiriro ekusimudzira uye kushandiswa kwespermidine
Spermidine inonzi polyamine inowanzoitika. The physiological content ye spermidine yakasikwa, inoshanda, yakachengeteka uye isina chepfu. Nekudzidza kwakadzama kwespermidine's more physiological effects, yakaratidza kukosha kwekushandisa mundima dzakawanda dzakadai semushonga, chikafu chehutano, zvekurima, zvizorwa uye zvichingodaro.
Mushonga
Spermidine ine zvakasiyana-siyana zvemuviri mhedzisiro senge anti-kuchembera, anti-kuzvimba, anti-kenza, nekuvandudza cognition. Inogona kushandiswa kudzivirira uye kurapwa kweosteoarthritis, nerve cell kukuvara, chirwere chemoyo uye zvimwe zvirwere. Spermidine inoshandiswa mumakiriniki ekushandisa. Kurapa kwechirwere kune tarisiro yakanaka yebudiriro.
Zvokudya zvoutano
Kushandisa "spermidine" uye "functional food raw materials" semashoko makuru ekutsvaga data mumadhatabhesi akawanda, zvigumisiro zvinoratidza kuti "spermidine" kana "spermine" inotsanangurwa sechikafu chinoshanda, uye spermidine yakatengeswa pamusika ne spermidine. . Chikafu chehutano chine amine sechinhu chikuru mbishi.
Zvigadzirwa zvehutano zvine chekuita neSpermidine zvine mabasa akasiyana uye anoshandiswa zvakanyanya mumhando dzakasiyana siyana, kusanganisira mapiritsi, hupfu uye mamwe mafomu ekuyerwa. Iine mabasa ekurwisa-kuchembera, kunatsiridza kurara, uye kuvandudza hutachiona; iyo yakasikwa spermidine chikafu poda yakabviswa kubva mugorosi germ inovimbisa kuchena kwepamusoro uye basa rakakwirira re spermidine.
Agriculture
Semugadziri wekukura kwechirimwa, kushandiswa kwekunze kwe spermidine kunogona kunyatso kudzikamisa kukuvadzwa kwezvirimwa kunokonzerwa nekushushikana senge tembiricha oxidation, tembiricha yakaderera uye kutonhora, hypoxia, munyu wakawanda, kusanaya kwemvura, mafashama uye kupinza, uye inoita basa rakakosha mukukura kwechirimwa. . Basa rayo rinokosha mukurima rakakwevera pfungwa zvishoma nezvishoma. Exogenous spermidine inogona kuderedza inhibitory mhedzisiro yekusanaya kwemvura pakukura kwemhunga inotapira uye kuwedzera kusanaya kwemvura kwembeu dzemhunga dzinotapira. Zvichienderana nebasa rakakosha respermidine mukukura kwechirimwa, ine akawanda ekugadzira patent mumunda wekurima. Kutsvaga nekugadzira zvigadzirwa zvekurima zvespermidine uye kusimudzira kushandiswa kwespermidine mumunda wekurima zvakakosha zvikuru mukusimudzira zvekurima.
Cosmetic
Spermidine ine antioxidant, anti-kuchembera, uye kukwidziridzwa kwe autophagy mhedzisiro, uye yakanaka cosmetic mbishi zvinhu. Parizvino, kune zvigadzirwa zvekuchengetedza ganda senge spermidine anti-kuchembera cream uye spermidine essence mukaka pamusika. Pamusoro pezvo, spermidine ine akawanda ekutsvagisa patent mumunda wezvizoro pasi rese, zvinosanganisira kuchena, kurwisa ganda kuchembera, uye kuvandudzwa kwemakwinya kumeso. Tsvakurudzo yakadzama pamusoro pemaitiro ekuita kwespermidine, kupfumisa mafomu ayo ekunyorera, uye kuongorora kuchengetedzwa nemhedzisiro inotarisirwa kupa vatengi sarudzo dzakachengeteka uye dzinoshanda dzekuchengetedza ganda.
Muvanhu, mazinga ekutenderera espermidine anowanzo ari mune yakaderera micromolar renji, kazhinji nekuda kwemhedzisiro yekudya pane yakazara spermidine concentration. Kunyangwe ivo vachiratidza misiyano yakasimba yepakati. Zvisinei, sezvatinokura, huwandu hwespermidine mumasero emuviri wedu hunoderera. Exogenous spermidine supplementation inodzoreredza kuchinja kwakashata kwakabatana nezera uye kunonoka kuchembera.
● Prescine / spermine metabolism
Mumasero emammalian, spermidine inogadzirwa kubva kune yayo precursor putrescine (iyo pachayo inogadzirwa kubva kuornithine) kana neiyo oxidative degradation yespermine.
●Gut microbiota
Iyo intestinal microbiota ndiyo yakakosha sosi ye spermidine synthesis. Mumakonzo, kuwanda kwespermidine mumatumbo lumen kwakaratidzwa kuve kwakanangana necolonic microbiota.
●Nzvimbo dzezvokudya
Spermidine inopedzwa kubva mukudya inogona kukurumidza kutorwa kubva mumatumbo uye kugoverwa mumuviri, saka kudya chikafu chakakwirira mu spermidine kunogona kubatsira kuwedzera spermidine mazinga mumuviri.
●Spermidine supplements
Zvigadzirwa zvehutano zvine chekuita neSpermidine zvine mabasa akasiyana uye anoshandiswa zvakanyanya mumhando dzakasiyana siyana, kusanganisira mapiritsi, hupfu uye mamwe mafomu ekuyerwa. Iine mabasa ekurwisa-kuchembera, kunatsiridza kurara, uye kuvandudza hutachiona; iyo yakasikwa spermidine chikafu poda yakabviswa kubva mugorosi germ inovimbisa kuchena kwepamusoro uye basa rakakwirira re spermidine.
Kuchena uye Hunhu
Paunenge uchitenga spermidine powder, zvakakosha kuisa mberi kuchena uye hutano. Tsvaga zvigadzirwa zvakagadzirwa kubva kune zvemhando yepamusoro zvinongedzo uye zvakaomesesa zvakaedzwa kuchena uye kushanda. Zvakanaka, sarudza zvigadzirwa zvakagadzirwa mumafekitori anotevera Yakanaka Kugadzira Maitiro (GMP) kuve nechokwadi chemhando uye chengetedzo.
Bioavailability
Bioavailability zvinoreva kugona kwemuviri kutora nekushandisa chinhu. Paunosarudza spermidine powder, funga nezve bioavailability yechigadzirwa. Tarisa fomura rakagadzirirwa kunyura kwakaringana, sezvo izvi zvichizoita kuti muviri wako ugone kushandisa spermidine nemazvo kuendesa zvingangoita hutano hutano.
Kujeka uye yechitatu-bato bvunzo
Iyo yekutsvagisa uye kugadzirwa kweiyo inoremekedzwa spermidine poda inofanirwa kuve pachena. Tsvaga mabhureki anopa ruzivo rwakadzama nezve kutsvagirwa kwezvinhu zvavo uye kugadzirwa kwezvigadzirwa zvavo. Pamusoro pezvo, kuyedzwa kwevatatu nemarabhoritari akazvimirira kunovimbisa kunaka kwechigadzirwa uye kuchena. Tarisa zvigadzirwa zvakaedzwa nevechitatu-bato masangano kuti vaone kushanda kwavo uye kuchengetedzeka.
Dosage uye Saizi Yekushumira
Paunenge uchitenga spermidine poda, funga nezve dosi uye saizi yekushumira inonyatsoenderana nezvido zvako. Zvimwe zvigadzirwa zvinogona kupa huwandu hwepamusoro hwespermidine pakushumira, nepo zvimwe zvigadzirwa zvinogona kupa muyero wakaderera. Izvo zvakakosha kuti uone muyero wakakodzera unoenderana nezvinangwa zvehutano hwako uye kubvunza nyanzvi yezvehutano pazvinenge zvichidikanwa.
Recipe uye zvimwe zvinongedzo
Spermidine poda inowanikwa mumhando dzakasiyana dzeyero, kusanganisira capsule, hupfu kana fomu yemvura. Funga kuti ndeipi fomati inonyatsoenderana nemararamiro ako uye zvaunofarira. Pamusoro pezvo, zvimwe zvigadzirwa zvinogona kunge zvine zvimwe zvinongedzo zvekuwedzera mhedzisiro yespermidine kana kunatsiridza kuravira kwayo. Teerera kune chero akawedzera zvinongedzo uye ita shuwa kuti anosangana nezvako zvekudya zvaunofarira uye zvirambidzo.
Mutengi wongororo uye mukurumbira
Usati watenga, tora nguva yekutsvaga mukurumbira wemhando uye uverenge wongororo yevatengi. Tarisa mhinduro kubva kune vanhu vakashandisa chigadzirwa kuti vawane nzwisiso yekushanda kwayo uye chero zvingangoitika mhedzisiro. Zvigadzirwa zvine mukurumbira wakanaka uye kutarisisa kwevatengi kunowanzo kupa yakavimbika uye yemhando yepamusoro spermidine poda.
Mutengo vs kukosha
Nepo mutengo usingafanire kunge uri iwo wega wekusarudza, zvakakosha kufunga kukosha kwechigadzirwa maererano nemutengo wacho. Enzanisa mutengo weakasiyana spermidine poda uye funga nezvemhando, kuchena, uye mamwe mabhenefiti echigadzirwa chimwe nechimwe. Kuisa mari mumhando yepamusoro yespermidine poda inogona kupa hutano hwakanyanya hunobatsira.
Suzhou Myland Pharm's Spermidine Powder-Yepamusoro-mhando yekudya yekuwedzera
PaSuzhou Myland Pharm, takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu spermidine poda inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu spermidine poda ndiyo sarudzo yakakwana.
Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika yekugadzira uye kugadzira masevhisi kambani.
Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvazvino uye zvinoshanda-akawanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye magadzirirwo ekugadzira GMP.
Mubvunzo: Chii chinonzi spermidine powder uye chinobatana sei nekukwegura?
A: Spermidine ndeye yakasikwa polyamine komboni inowanikwa mune zvakasiyana zvekudya uye nemuviri wemunhu. Tsvagiridzo inoratidza kuti spermidine inogona kuve ne-anti-kuchembera mhedzisiro nekusimudzira hutano hweserura uye hupenyu hurefu.
Mubvunzo: Ko spermidine powder inoshanda sei kurwisa kukwegura?
A: Spermidine inotendwa kuti inomutsa cellular process inonzi autophagy, iyo inobatsira kubvisa masero akakuvadzwa uye kukurudzira kuvandudzwa kwemasero ane hutano. Iyi nzira inofungidzirwa kuti ine basa guru mukuderedza kukwegura.
Mubvunzo: Ndezvipi zvingave zvinobatsira zvekutora spermidine powder yekukwegura?
A: Zvimwe zvidzidzo zvakaratidza kuti spermidine supplementation inogona kubatsira kuvandudza hutano hwemwoyo, kushanda kwehuropi, uye hupenyu hurefu. Inogonawo kunge iine mabhenefiti ehutano hweganda uye immune function.
Q: Ndingaite sei kuti ndive nechokwadi chemhando ye spermidine poda kana ndichiitenga online?
A:Tsvaga mutengesi ane mukurumbira uye akasimbiswa ane rekodhi rekodhi yekupa zvemhando yepamusoro zvekudya zvinowedzera. Tarisa kuongororwa kwevatengi uye zviyero kuti uone kuvimbika kwemutengesi.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Aug-28-2024
