Palmitoylethanolamide is endogenous fatty acid amide inova yekirasi yenyukireya factor agonists. Icho chimwe chezvinonyanya kukosha endogenous analgesic uye anti-inflammatory compounds zvakaratidzwa kuti zvinoshanda kwete chete mukurwadziwa kwakanyanya asiwo kusingaperi. Sezvinogadzirisa marwadzo echisikigo, inzira yakanaka kune mishonga yechinyakare inogona kukonzera mhedzisiro.
PEA yakaratidzwa kuva ne-anti-inflammatory, antinociceptive, neuroprotective, uye anticonvulsant properties. PEA yanga ichiongorora vanhu vane marwadzo akasiyana siyana, kuzvimba uye kurwadziwa syndromes mumakiriniki akasiyana miedzo. Zvishandiso: Palmitoylethanolamide ndeye organic synthesis yepakati uye yemishonga yepakati, iyo inogona kushandiswa murabhoritari tsvakurudzo nekusimudzira maitiro uye kemikari uye mishonga yekutsvaga nekusimudzira maitiro.
Mumazuva ano ekutsvagisa kwesainzi uye minda yeindasitiri, Palmitoylethanolamide, sechinhu chakakosha chemakemikari mbishi, yakagamuchira kutariswa kwakapararira kune yakasarudzika makemikari zvimiro uye yakafara tarisiro yekushandisa.
1. Kugadzirira kwePalmitoylethanolamide
Kugadzirira kwePalmitoylethanolamide kazhinji kunosanganisira kuita esterification. Munguva yekugadzirira, palmitadecanoic acid uye ethanol inopinda esterification reaction pasi pechiito checatalyst kugadzira palmitadecanamide ethanol. Munguva yegadziriro yekugadzirira, zvinhu zvakaita seyekuita tembiricha, catalyst type uye dosage, uye nguva yekuita zvine zvazvinoita pamhando uye goho rechigadzirwa. Naizvozvo, kugadzirisa maitiro ekugadzirira ndiyo kiyi yekuvandudza chigadzirwa chemhando uye kuderedza mutengo.
2. Zvinhu zvePalmitoylethanolamide
Palmitoylethanolamide ichena kusvika zvishoma yero yakasimba ine yakanaka solubility uye kugadzikana. Iyo yakasimba pakushambidzika kwekamuri, asi inonyungudika mumhando dzakasiyana-siyana dzemakemikari pane imwe tembiricha, senge ethanol, acetone, etc. Mukuwedzera, Palmitoylethanolamide inewo kunaka kwekushisa uye kugadzikana kwemakemikari, iyo inobvumira kuchengetedza maitiro ayo uye zvinhu pasi pe. kupisa kwepamusoro uye nzvimbo dzakaoma.
3. Kushandiswa kwePalmitoylethanolamide
1. Pharmaceutical uye marabhoritari tsvagiridzo nekusimudzira:
●PEA inokosha yemishonga yepakati, inoshandiswa mu laboratori tsvakurudzo nekuvandudza maitiro uye makemikari emishonga ekutsvakurudza nekuvandudza maitiro.
● Yakaratidzwa kuva ne-anti-inflammatory, analgesic, neuroprotective uye anticonvulsant properties uye yakakodzera kurapwa kwemarwadzo asingagumi, pfari, cerebral ischemia uye sitiroko.
2. Indasitiri yezvekuzora:
●PEA ine mashandiro esurfactant uye foam accelerator uye inoshandiswa mukugadzira zvizoro zvakaita semoisturizer neshamposi.
● Inogona kuwedzera kuwirirana uye kugadzikana kwechigadzirwa, apo ichivandudza kunyorova uye kunyorova kwechigadzirwa.
3. Indasitiri yemachira:
● PEA inoshandiswa sechinyoro, antistatic agent uye lubricant kuti ivandudze kupfava uye kupenya kwemachira uye kuderedza friction coefficient uye electrostatic effects.
4. Plastic industry:
● Se plasticizer, lubricant uye dispersant, PEA inovandudza kupfava uye kuoma kwemapurasitiki uye inoderedza kupisa kwekugadzirisa uye kushandiswa kwesimba.
5. Anti-inflammatory uye analgesic:
● PEA inoderedza zviratidzo zvinopisa nekushandura gene expression, ine anti-inflammatory and analgesic effects, uye yakakodzera kurapa zvirwere zvakasiyana-siyana uye zvirwere zvinopisa.
6. Zvimwe zvingangoshandiswa:
● Mundima yesimba idzva, PEA inogona kushandiswa kugadzira zvinhu zvitsva zvesimba zvakadai semasero ezuva uye lithium-ion mabhatiri.
● Mumunda wekuchengetedzwa kwezvakatipoteredza, inogona kushandiswa kugadzira mapurasitiki anoodegradable, machira ane ushamwari kwezvakatipoteredza uye zvimwe zvigadzirwa zvine hushamwari.
● Mundima yemishonga, inogona kushandiswa kugadzira zvinhu zvemishonga zvakadai sevatakuri vezvinodhaka uye vamiririri vanoramba vachisunungurwa.
Aya mashandisirwo anoratidza iyo yakafara application uye inogona kukosha yepalmitamide ethanol mumaindasitiri akawanda.
4. Remangwana rekuvandudza maitiro ePalmitoylethanolamide
Nekuenderera mberi kwekufambira mberi kwesainzi uye tekinoroji uye kukurumidza kukura kweindasitiri, minda yekushandisa yePalmitoylethanolamide icharamba ichiwedzera. Mune ramangwana, kushandiswa kwePalmitoylethanolamide musimba idzva, kuchengetedzwa kwezvakatipoteredza, mushonga uye mamwe minda ichawedzera zvishoma nezvishoma. Semuenzaniso, mumunda wesimba idzva, Palmitoylethanolamide inogona kushandiswa kugadzira zvinhu zvitsva zvesimba zvakadai semasero ezuva uye lithium-ion mabhatiri; mumunda wekuchengetedzwa kwezvakatipoteredza, inogona kushandiswa kugadzira zvigadzirwa zvezvakatipoteredza zvakadai semapurasitiki anoodegradable uye machira ane ushamwari; mumunda wemishonga, inogona kushandiswa Kugadzira mishonga yemishonga yakadai sevatakuri vezvinodhaka uye vamiririri vakasununguka.
Pamusoro pezvo, sezvo kuziva kwevanhu nezvehutano nekuchengetedzwa kwezvakatipoteredza kuri kuramba kuchiwedzera, kunaka uye kuita zvinodiwa zvePalmitoylethanolamide zvichavawo zvakakwirira uye zvakakwirira. Naizvozvo, tsvakiridzo yeramangwana uye kusimudzira uye kugadzirwa kwePalmitoylethanolamide kuchabhadhara zvakanyanya kuchengetedza kwezvakatipoteredza, kuchengetedzwa uye kusimba. Panguva imwecheteyo, kuitira kuzadzisa zvinodikanwa zveminda dzakasiyana, kutsvagisa uye kuvandudzwa kwePalmitoylethanolamide mitsva inobuda ichavawo gwara rakakosha mune ramangwana.
PEA ndeye endogenous fatty acid amide inova yekirasi yenyukireya factor agonists. PEA yakaratidzwa kuti inosunga kune zvinogamuchirwa mu nucleus (nuclear receptors) uye inoshandisa zvakasiyana-siyana zvehupenyu hwehupenyu hune chokuita nekurwadziwa kusingaperi uye kuzvimba. Chinangwa chikuru chinofungidzirwa kuve peroxisome proliferator-activated receptor alpha (PPAR-alpha).
Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena Oleoylethanolamide (OEA) upfu.
PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Oleoylethanolamide (OEA) poda inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu Oleoylethanolamide (OEA) poda ndiyo sarudzo yakakwana.
Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.
Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Sep-27-2024
