Dopamine inonakidza neurotransmitter inoita basa rakakosha mumubairo wehuropi nenzvimbo dzekunakidzwa. Kazhinji inonzi "kunzwa-kunaka" kemikari, ine chekuita neakasiyana ehupenyu uye hwepfungwa maitiro anokanganisa mafungiro edu ese, kukurudzira, uye kunyange kupindwa muropa maitiro.
Dopamine, inowanzonzi "kunzwa zvakanaka" neurotransmitter, yakatanga kuwanikwa muma1950 nemusayendisiti wekuSweden Arvid Carlsson. Inotsanangurwa se monoamine neurotransmitter, zvinoreva kuti ikemikari messenger inotakura zviratidzo pakati pemasero etsinga. Dopamine inogadzirwa munzvimbo dzinoverengeka dzehuropi, kusanganisira iyo substantia nigra, ventral tegmental nzvimbo, uye hypothalamus yehuropi.
Basa guru re dopamine ndere kufambisa masaini pakati peeuroni uye kupesvedzera akasiyana mabasa emuviri. Inofungidzirwa kudzora kufamba, mhinduro dzemanzwiro, kukurudzira, uye manzwiro ekunakidzwa nemubairo. Dopamine inoitawo basa rakakosha mumatanho akasiyana ekuziva akadai sekudzidza, ndangariro, uye kutarisisa.
Kana dopamine ichiburitswa muuropi nzira yemubairo, inoburitsa manzwiro ekunakidzwa kana kugutsikana.
Munguva dzemafaro uye mubairo, tinoburitsa yakawanda ye dopamine, uye kana mazinga akanyanya kuderera, tinonzwa tisina kukurudzirwa uye tisingabatsiri.
Pamusoro pezvo, hurongwa hwemubairo wehuropi hwakasungirirwa zvakanyanya kune dopamine. Basa remaurotransmitters nderekusimudzira manzwiro ekunakidzwa nekusimbisa, nekudaro zvichiunza kukurudzira. Kutisundidzira kuzadzisa zvinangwa zvedu uye kutsvaga mibairo.
Dopamine inogadzirwa munzvimbo dzakawanda dzehuropi, kusanganisira iyo substantia nigra uye ventral tegmental nzvimbo. Idzi nzvimbo dzinoita se dopamine mafekitori, kugadzira uye kuburitsa iyi neurotransmitter muzvikamu zvakasiyana zvehuropi. Kana yangoburitswa, dopamine inosunga kune chaiyo receptors (inonzi dopamine receptors) iri pamusoro pesero rinogamuchira.
Kune marudzi mashanu e dopamine receptors, akanyorwa kuti D1 kune D5. Mhando yega yega yekugamuchira inowanikwa mune imwe nzvimbo yehuropi, ichibvumira dopamine kuva nemhedzisiro yakasiyana. Apo dopamine inosunga kune receptor, inofadza kana kuvharidzira basa rekugamuchira sero, zvichienderana nemhando yekugamuchira iyo yakabatanidzwa.
Dopamine inoita basa rakakosha mukudzora kufamba munzira ye nigrostriatal. Munzira iyi, dopamine inobatsira kudzora uye kurongedza kuita kwemhasuru.
Mune prefrontal cortex, dopamine inobatsira kudzora ndangariro yekushanda, ichitibvumira kubata uye kushandura ruzivo mupfungwa dzedu. Inoitawo basa mukutarisisa uye kuita sarudzo. Kusaenzana mumazinga e dopamine mu prefrontal cortex kwakabatanidzwa kune mamiriro akadai sekutarisisa deficit hyperactivity disorder (ADHD) uye schizophrenia.
Kuburitswa uye kudzorwa kwe dopamine kwakanyatso kudzorwa nehuropi kuchengetedza chiyero uye kuve nechokwadi chenguva dzose basa. Iyo yakaoma sisitimu yemhinduro nzira, inosanganisira mamwe neurotransmitters uye uropi nzvimbo, inogadzirisa dopamine mazinga.
Dopamine ikemikari messenger, kana neurotransmitter, muuropi inotakura zviratidzo pakati pemasero etsinga. Inobata basa rinokosha mumabasa akasiyana-siyana ehuropi, kusanganisira kudzora kufamba, mafungiro, uye mhinduro dzemanzwiro, zvichiita kuti ive chikamu chakakosha chehutano hwedu hwepfungwa. Nekudaro, kusaenzana mumazinga e dopamine kunogona kutungamira kune dzakasiyana siyana hutano hwepfungwa.
●Tsvagiridzo inoratidza kuti vanhu vane kuora mwoyo vanogona kunge vaine yakaderera dopamine mazinga mune dzimwe nzvimbo dzehuropi, zvichikonzera kuderedzwa kukurudzira uye kunakidzwa mumabasa ezuva nezuva.
●Imbalanced dopamine mazinga anogona kukonzera kusagadzikana kusagadzikana. Kuwedzera dopamine chiitiko mune dzimwe nzvimbo dzehuropi kunogona kukonzera kuwedzera kunetseka uye kusagadzikana.
●Yakawandisa dopamine chiitiko munzvimbo dzakati dzehuropi inofungidzirwa kuti inobatsira kune zviratidzo zveschizophrenia, zvakadai sekufungidzira uye kunyengera.
●Zvinodhaka uye maitiro ekupindwa muropa anowanzo kuwedzera dopamine mazinga muuropi, zvichikonzera euphoric uye manzwiro anogutsa. Nokufamba kwenguva, uropi hunova hunoenderana nezvinhu izvi kana maitiro ekusunungura dopamine, zvichiita kutenderera kwekupindwa muropa.
Mubvunzo: Mishonga inogona kushandiswa kugadzirisa dopamine mazinga?
A: Hongu, mimwe mishonga, yakadai se dopamine agonists kana dopamine reuptake inhibitors, inoshandiswa kurapa mamiriro ane chokuita ne dopamine dysregulation. Iyi mishonga inogona kubatsira kudzoreredza dopamine muuropi uye kuderedza zviratidzo zvine chekuita nemamiriro akaita sechirwere cheParkinson kana kushushikana.
Mubvunzo: Munhu angachengetedza sei hutano hwe dopamine?
A: Kuchengeta mararamiro ane hutano, kusanganisira kurovedza muviri nguva dzose, kudya kunovaka muviri, kurara kwakakwana, uye kugadzirisa kunetseka, zvinogona kuita kuti zvive zvakakwana dopamine regulation. Kuita zvinhu zvinonakidza, kuisa zvinangwa zvinogoneka, uye kudzidzira kufunga kunogona kubatsirawo kuchengetedza hutano hwakanaka hwe dopamine.
Disclaimer: Ichi chinyorwa ndechezvinangwa zveruzivo chete uye hachifanirwe kutorwa sezano rekurapa. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kushandura hutano hwehutano hwako.
Nguva yekutumira: Sep-15-2023