Iyo inorwisa-kuzvimba mhedzisiro yeOEA inosanganisira kugona kwayo kudzikisa kugadzirwa kwepro-kuzvimba mamorekuru, inhibit immune cell activation, uye modulate marwadzo echiratidzo nzira. Aya maitiro anoita OEA inovimbisa yekurapa chinangwa chekurapa kuzvimba uye kurwadziwa.
Oleoylethanolamide, kana OEA kwenguva pfupi, inongoitika lipid molecule inova yekirasi yemakomponi anozivikanwa sefatty acid ethanolamides. Miviri yedu inogadzira iyi musanganiswa mudiki, kunyanya mudumbu diki, chiropa, uye mafuta tishu. Nekudaro, OEA inogona zvakare kuwanikwa kubva kune ekunze masosi, senge zvimwe zvekudya uye zvekudya zvinowedzera.
OEA inofungidzirwa kuita basa mu lipid metabolism. Lipids yakakosha kumabasa mazhinji emuviri, kusanganisira kuchengetedza simba, kuvharisa, uye kugadzirwa kwehomoni. Yakafanira lipid metabolism yakakosha kuchengetedza hutano hwakakwana, uye OEA inogona kubatsira kudzora maitiro aya. 
Tsvagiridzo inoratidza kuti OEA inogona kukanganisa BP, mutsinga toni, uye endothelial basa-zvinhu zvakakosha pakuchengetedza tsinga dzine hutano. Nekusimudzira vasodilation uye nekuvandudza kuyerera kweropa, OEA inogona kubatsira kurwisa kutetepa kwetsinga dzinokonzerwa nekuvakwa kweplaque.
OEA inogona zvakare kuve ne-anti-kuzvimba uye lipid-kudzikisa zvivakwa, izvo zvinogona kuve nemhedzisiro yakanaka pane arteriosclerosis uye zvine chekuita nezvirwere. Yakaratidzwa kuderedza kuumbwa kweplaque, kuzvimba, uye oxidative kusagadzikana mumhando dzemhuka dzeatherosclerosis.
Zvidzidzo zvakawanawo kuti OEA inogona kuvandudza ropa lipid profiles nekudzikisa triglycerides uye yakaderera-density lipoprotein (LDL) cholesterol mazinga ichiwedzera high-density lipoprotein (HDL) cholesterol.
1. Kuronga kwechido uye kudzora uremu
Imwe yemabhenefiti ehutano akanyanya eOEA kugona kwayo kudzora chishuwo uye kusimudzira uremu huremu. Zvidzidzo zvakawana kuti OEA inokanganisa kuburitswa kwehomoni yenzara, zvichitungamira kumanzwiro ekuzara uye kuderedzwa kwekudya. Tsvagiridzo inoratidza kuti OEA inobatsira kumisa mamwe ma receptors mudumbu remukati, izvo zvinowedzera satiety. Nekugadzirisa kudya, OEA inogona kupa rubatsiro rwakakosha pakuedza kwekutonga uremu.
2. Kugadzirisa marwadzo
Oleoylethanolamide (OEA) yakadzidziswawo nezve mukana wayo wegomarara. OEA yakaratidzwa kuti iite mamwe ma receptors mumuviri, senge peroxisome proliferator-activated receptor alpha (PPAR-α) uye yenguva pfupi yekugamuchira inogona kuva vanilloid mhando 1 (TRPV1) receptor. Kushanda kweaya mareceptor kunogona kutungamirira kumodulation yemarwadzo echiratidzo mumuviri.
OEA yakawanikwa iine analgesic mhedzisiro mumhando dzakasiyana dzemhuka dzemarwadzo, kusanganisira marwadzo neuropathic uye kurwadziwa kwekuzvimba. Yakaratidzwa kuderedza hyperalgesia (kureva kuwedzera kurwadziwa kwekunzwa) uye kuderedza maitiro ane chokuita nemarwadzo. Imwe nzira inotsanangurwa yekuita kugona kwayo kudzikisa kuburitswa kwepro-kuzvimba mamorekuru uye kudzoreredza kuzvimba, nekudaro zvichikonzera marwadzo kuona.
3. Utano hwemwoyo
Humbowo huri kubuda hunoratidza kuti OEA inogona kubatsirawo hutano hwemoyo. OEA yakaratidzwa kuderedza kuzvimba, kuvandudza insulin senitivity uye kudzora cholesterol mazinga. Izvi zvinhu zvakakosha kuchengetedza hutano hwemoyo uye kuderedza njodzi yemamiriro akaita sekurwadziwa kwemoyo uye sitiroko. Iko kugona kweOEA seanodzivirira mwoyo inoita kuti ive chinangwa chinovimbisa chekuwedzera kutsvagisa mukurapa kwemoyo.
4. Neuroprotection uye Mental Health
Mhedzisiro yeOEA inowedzera kupfuura hutano hwemuviri, sezvo yakaratidzwa kuva neuroprotective zvivakwa. Zvidzidzo zvakaratidza kuti OEA inogona kubatsira kuchengetedza masero ehuropi kubva kune oxidative kusagadzikana uye kuzvimba, izvo zvinhu zvakakosha muzvirwere zvakasiyana neurodegenerative. Pamusoro pezvo, OEA yakabatanidzwa nekugadziriswa kwemood-regulating neurotransmitters seserotonin. Naizvozvo, OEA inogona kuita basa mukutsigira hutano hwepfungwa uye kurwisa kusagadzikana sekushushikana uye kushushikana.
5. Anti-inflammatory uye lipid-kuderedza zvinhu
OEA yakawanikwawo iine lipid-kudzikisa mhedzisiro, kunyanya pa triglyceride uye cholesterol mazinga. Inowedzera kuparara uye kubviswa kwe triglycerides muropa, nokudaro kuderedza triglyceride mazinga. OEA yakaratidzawo kuderedza cholesterol synthesis uye kunwisa, nokudaro zvichibatsira kuderedza LDL cholesterol mazinga.
Pamusoro pezvo, OEA yakaratidza kudzikisira kuzvimba nekumisikidza chiitiko cheanopisa mamaki uye cytokines mumatishu akasiyana. Inogona kubatsira kudzivisa kusunungurwa kwepro-inflammatory molecules yakadai se tumor necrosis factor-alpha (TNF-α) uye interleukin-1 beta (IL-1β).
Oleoylethanolamide (OEA) inongoitika fatty acid inotorwa iyo inoshanda sechiratidzo chemorekuru mumuviri. Iyo inonyanya kugadzirwa mudumbu diki uye inobatsira kudzora chiyero chesimba, chishuwo, uye lipid metabolism.
Iyo yekutanga receptor yeOEA chiito inonzi peroxisome proliferator-activated receptor alpha (PPAR-α). PPAR-α inonyanya kuratidzwa munhengo dzakadai sechiropa, ura hudiki, uye adipose tissue. Kana OEA ichisunga kuPPAR-α, inomutsa kuyerera kwemaitiro ebiochemical ane akawanda mhedzisiro pametabolism uye kutonga kwechido, zvinozotungamira mukudzikira kwekudya uye kuwedzera kwekushandisa kwesimba.
Pamusoro pezvo, OEA yakaratidzwa kukurudzira kuparara, kana lipolysis, yemafuta akachengetwa muadipose tissue. Izvi zvinoitwa nekuita ma enzymes anobatsira kuparara kwe triglycerides kuita fatty acids, iyo inogona kushandiswa nemuviri sechitubu chesimba. OEA inowedzerawo kutaura kwemajini anosanganisirwa mumafuta acid oxidation, iyo inowedzera kushandiswa kwesimba uye kupisa mafuta.
Pakazere, maitiro ekuita kweOEA anosanganisira kudyidzana kwayo nema receptors chaiwo mumuviri, kunyanya PPAR-α, kudzora chiyero chesimba, kudya, uye lipid metabolism. Nekuita izvi zvinogamuchirwa, OEA inogona kukurudzira kuguta, kuwedzera lipolysis, uye kuita anti-kuzvimba mhedzisiro.
●Dosage zvinokurudzirwa:
Kana zvasvika kune OEA dosage, zvakakosha kuziva kuti tsvakiridzo yakakura muvanhu ichiri kuenderera. Nekudaro, zvichibva pakutsvagisa kuripo uye neanecdotal humbowo, hunoshanda hwezuva nezuva mwero weOEA unofanirwa kutanga nemari shoma.
Izvo zvakakosha kubvunza nyanzvi yezvehutano usati watanga chero chitsva chekuwedzera, kusanganisira OEA. Vanogona kupa zano remunhu zvichienderana nezvako chaizvo zvaunoda uye mamiriro ehutano, zvichikubatsira kuona iyo yakakodzera dosi yemamiriro ako akasiyana.
●Side Effects uye Kuchengetedzeka:
Nepo OEA ichiwanzoonekwa yakachengeteka kunwiwa, zvakakosha kuti uzive zvinogona kuitika:
1.Kusagadzikana kweGastrointestinal: Mune zvimwe zviitiko, kuwedzera kweOEA kunogona kukonzera kusagadzikana kwemudumbu, sekusvotwa kana kugumbuka mudumbu. Mhedzisiro iyi inowanzoenderana nedosi uye inoderera nekufamba kwenguva.
2.Kudyidzana neZvinodhaka: OEA inogona kudyidzana nemimwe mishonga, kusanganisira iyo inoshandiswa pakudzora kweropa kana cholesterol manejimendi. Naizvozvo, zvakakosha kuti uzivise mutarisiri wako wehutano nezve chero ekuwedzera iwe yauri kutora kuti udzivise chero chingangoita kudyidzana kwezvinodhaka.
3.Allergic Reactions: Sezvakaita chero chekuwedzera, vamwe vanhu vanogona kunge vakanzwa kana kusawirirana neOEA. Kana iwe ukaona chero maitiro asina kunaka akadai semapundu, kukwenya, kana kunetseka kufema, rega kushandisa uye tsvaga kurapwa nekukurumidza.
Mubvunzo: Zvinotora nguva yakareba sei kuti uwane mabhenefiti eOleoylethanolamide?
A: Nguva inodiwa kuti uwane mabhenefiti eOleoylethanolamide inogona kusiyana kubva kune mumwe nemumwe. Nepo vamwe vanhu vachiona kuvandudzwa kwekuzvimba uye kurwadziwa nekukurumidza, zvinogona kutora nguva yakareba kuti vamwe vaone izvi. Izvo zvakakosha kuenderana nekutora Oleoylethanolamide uye kutevedzera yakakurudzirwa dosi.
Mubvunzo: Ndingawane kupi Oleoylethanolamide supplements?
A: Oleoylethanolamide supplements inogona kuwanikwa muzvitoro zvekudya zvehutano, ma pharmacy, uye vatengesi vepamhepo. Paunenge uchitenga zvekuwedzera, ita shuwa kuti unosarudza zvigadzirwa kubva kune ane mukurumbira mabhureki anoteera kune emhando zviyero uye akaedzwa wechitatu-bato.
Disclaimer: Ichi chinyorwa ndechezvinangwa zveruzivo chete uye hachifanirwe kutorwa sezano rekurapa. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kushandura hutano hwehutano hwako.
Nguva yekutumira: Jul-24-2023
