Simba retaurine rinopfuura fungidziro yako!

Munguva pfupi yapfuura, tsvakiridzo pamusoro petaurine yakaburitswa mumagazini matatu makuru eScience, Cell, and Nature. Zvidzidzo izvi zvakaratidza mabasa matsva etaurine - kudzivirira kukwegura, kuvandudza mhedzisiro yekurapa kenza, uye kudzivirira kufuta.

Muna Chikumi 2023, vaongorori vanobva kuNational Institute of Immunology muIndia, Columbia University muUnited States, nedzimwe nzvimbo vakaburitsa mapepa mumagazini yepamusoro yedzidzo yepasi rose inonzi Science. Chidzidzo ichi chinoratidza kuti kushomeka kwetaurine ndiko kunokonzera kukwegura. Kuwedzera taurine kunogona kunonotsa kukwegura kwenematodes, mbeva, netsoko, uye kunogona kutowedzera hupenyu hwakanaka hwembeva dzepakati nepakati ne12%. Tsanangudzo: Sainzi: Simba rinopfuura fungidziro yako! Taurine inogonawo kudzosera kukwegura uye kuwedzera hupenyu?

Muna Kubvumbi 2024, Purofesa Zhao Xiaodi, Mubatsiri Purofesa Lu Yuanyuan, Purofesa Nie Yongzhan, naPurofesa Wang Xin vekuXijing Hospital yeFourth Military Medical University vakaburitsa mapepa mumagazini yepamusoro yedzidzo yepasi rose inonzi Cell. Chidzidzo ichi chakawana kuti masero egomarara anokwikwidzana nemasero eCD8+ T kuti awane taurine nekushandisa taurine transporter SLC6A6 zvakanyanya, izvo zvinokonzera kufa kwemasero eT uye kuneta, zvichikonzera kubuda kwemasero egomarara, nokudaro zvichikurudzira kukura kwegomarara uye kudzoka kwaro, nepo kuwedzera Taurine kuchigona kumutsa masero eCD8+ T akaneta uye kuvandudza kushanda zvakanaka kwekurapa kenza.

Musi wa7 Nyamavhuvhu, 2024, timu yaJonathan Z. Long weStanford University (Dr. Wei Wei ndiye munyori wekutanga) yakaburitsa bepa rekutsvagisa rine musoro unoti: PTER iN-acetyl taurine hydrolase inodzora kudya uye kufutisa mumagazini yepamusoro yedzidzo yepasi rose inonzi Nature.

Chidzidzo ichi chakawana N-acetyl taurine hydrolase yekutanga mumhuka dzinoyamwisa, PTER, uye chakasimbisa basa guru reN-acetyl taurine mukuderedza kudya uye kurwisa kufuta. Mune ramangwana, zvinokwanisika kugadzira mishonga inodzivirira kufuta ine simba uye inosarudza yekurapa kufuta.

Taurine inowanikwa zvakanyanya munyama dzemhuka dzinoyamwisa uye muzvikafu zvakawanda uye inowanikwa zvakanyanya munyama dzinokurumidza kugadzikana dzakadai semwoyo, maziso, uropi, uye tsandanyama. Taurine yakatsanangurwa kuti ine mabasa emasero eropa uye emuviri, kunyanya kana tichitarisa metabolic homeostasis. Kudzikiswa kwemajini mumazinga etaurine kunotungamira mukuora kwetsandanyama, kudzikira kwekugona kurovedza muviri, uye kusashanda zvakanaka kwemitochondrial munyama dzakawanda. Kuwedzera taurine kunoderedza kushushikana kwemitochondrial redox, kunovandudza kugona kurovedza muviri, uye kunoderedza huremu hwemuviri.

Biochemistry uye enzymology ye metabolism yetaurine zvakakwezva kufarira kukuru kwekutsvaga. Munzira ye endogenous taurine biosynthetic, cysteine ​​​​inogadziriswa ne cysteine ​​​​dioxygenase (CDO) uye cysteine ​​​​sulfinate decarboxylase (CSAD) kugadzira hypotaurine, iyo inozopedzisira yaitwa Oxidation ne flavin monooxygenase 1 (FMO1) inogadzira taurine. Pamusoro pezvo, cysteine ​​​​inogona kugadzira hypotaurine kuburikidza nenzira imwe ye cysteamine ne cysteamine dioxygenase (ADO). Pasi petaurine pachayo pane akati wandei secondary taurine metabolites, kusanganisira taurocholate, tauramidine, uye N-acetyl taurine. Enzyme chete inozivikanwa kuti inokonzeresa nzira idzi dziri pasi iBAAT, iyo inosanganisa taurine ne bile acyl-CoA kugadzira taurocholate nedzimwe bile salts. Kuwedzera kuBAAT, ma molecular identities emamwe ma enzymes anotungamira secondary taurine metabolism haasati awanikwa.

N-acetyltaurine (N-acetyl taurine) chinhu chinonakidza asi chisina kunyatsodzidzwa zvakanaka che taurine. Huwandu hweN-acetyl taurine muzvinhu zvipenyu hunodzorwa nekuchinja-chinja kwemuviri kunowedzera taurine uye/kana acetate flux, kusanganisira kurovedza muviri, kunwa doro, uye kuwedzera taurine. Pamusoro pezvo, N-acetyltaurine ine chimiro chemakemikari chakafanana nemamorekuru ekutumira zviratidzo anosanganisira neurotransmitter acetylcholine uye N-fatty acyltaurine refu-chain inodzora shuga yeropa, zvichiratidza kuti inogona kushandawo sechiratidzo chemetabolite. Zvisinei, biosynthesis, degradation, uye potential functions yeN-acetyl taurine hazvisati zvanyatsojeka.

Muchidzidzo ichi chazvino, chikwata chekutsvagisa chakaona PTER, enzyme isina basa rinozivikanwa, seN-acetyl taurine hydrolase huru yemhuka dzinoyamwisa. In vitro, recombinant PTER yakaratidza huwandu hwakamanikana hwesubstrate uye miganhu mikuru. MuN-acetyl taurine, inonyungudutswa kuita taurine neacetate.

Kubvisa jini rePter mumakonzo kunoguma nekurasikirwa zvachose kwebasa reN-acetyl taurine hydrolytic mumatishu uye kuwedzera kwehuwandu hweN-acetyl taurine mumatishu akasiyana-siyana.

Nzvimbo yePTER yemunhu inobatanidzwa nebody mass index (BMI). Chikwata chekutsvagisa chakaona zvakare kuti mushure mekukurudzirwa nekuwedzera kwemazinga etaurine, mbeva dzePter knockout dzakaratidza kuderera kwekudya uye dzaisakwanisa kufutisa nekuda kwekudya, uye glucose homeostasis yakavandudzika. Kuwedzera N-acetyl taurine kumakonzo emusango akafuta kwakadzikisawo kudya uye huremu hwemuviri nenzira inoenderana neGFRAL.

Data iri rinoisa PTER panzvimbo huru ye enzyme ye taurine secondary metabolism uye rinoratidza mabasa ePTER neN-acetyl taurine mukudzora huremu uye kuenzana kwesimba.

Zvose, chidzidzo ichi chakawana acetyl taurine hydrolase yekutanga mumhuka dzinoyamwisa, PTER, uye chakasimbisa basa rakakosha reacetyl taurine mukuderedza kudya uye kurwisa kufuta. Mune ramangwana, zvinotarisirwa kuti mishonga inodzivirira PTER ine simba uye yakasarudzwa ichagadzirwa yekurapa kufuta.