Simba retaurine rinopfuura fungidziro yako !!

Munguva pfupi yapfuura, tsvagiridzo yetaurine yakaburitswa mumagazini matatu epamusoro Sainzi, Cell, uye Nature. Zvidzidzo izvi zvakaratidza mabasa matsva etaurine - anti-kuchembera, kuvandudza maitiro ekurapa cancer, uye anti-kufutisa.

Muna Chikumi 2023, vaongorori kubva kuNational Institute of Immunology muIndia, Columbia University kuUnited States, nemamwe masangano akaburitsa mapepa mupepanhau repamusoro redzidzo reScience. Chidzidzo ichi chinoratidza kuti kushomeka kwetaurine mutyairi wekuchembera. Kuwedzera taurine kunogona kudzikisira kuchembera kwenematodes, mbeva, netsoko, uye kunogona kutowedzera hupenyu hune hutano hwemakonzo ezera repakati ne12%. Details: Sayenzi: Simba rinopfuura fungidziro yako! Taurine inogonawo kudzoreredza kuchembera uye kuwedzera hupenyu?

Muna Kubvumbi 2024, Muzvinafundo Zhao Xiaodi, Mubatsiri Muzvinafundo Lu Yuanyuan, Muzvinafundo Nie Yongzhan, naMuzvinafundo Wang Xin vekuchipatara cheXijing cheFourth Military Medical University vakaburitsa mapepa mupepanhau repamusoro redzidzo repasi rose Cell. Chidzidzo ichi chakawana kuti masero ebundu anokwikwidza neCD8+ T masero etaurine nekuwedzeredza taurine transporter SLC6A6, iyo inokonzeresa kufa kweT cell uye kupera simba, zvichiita kuti bundu ripukunyuke, nekudaro zvinosimudzira kufambira mberi kwebundu uye kudzokazve, nepo kuwedzera Taurine inogona kumutsa aneta CD8 + T masero. uye kunatsiridza kenza kurapwa kushanda zvakanaka.

Musi waNyamavhuvhu 7, 2024, timu yaJonathan Z. Long yeStanford University (Dr. Wei Wei ndiye munyori wekutanga) yakaburitsa bepa rekutsvagisa rakanzi: PTER iN-acetyl taurine hydrolase inodzora kudya uye kufutisa mune yepamusoro soro yezvidzidzo zvepasirese. magazini Nature.

Ichi chidzidzo chakawana yekutanga N-acetyl taurine hydrolase mumhuka dzinoyamwisa, PTER, uye yakasimbisa basa rakakosha reN-acetyl taurine mukuderedza kudya uye anti-kufutisa. Mune ramangwana, zvinokwanisika kugadzira PTER inhibitors ane simba uye anosarudza pakurapa kufutisa.

Taurine inowanikwa zvakanyanya mumammalian tishu uye zvikafu zvakawanda uye inowanikwa mune yakanyanya kukwirisa mumatishu anofadza akadai semoyo, maziso, uropi, uye tsandanyama. Taurine yakatsanangurwa kuti ine pleiotropic cellular uye physiological mabasa, kunyanya mumamiriro ekugadzirisa metabolic homeostasis. Kudzikiswa kweGenetic mumazinga etaurine kunotungamira kune tsandanyama atrophy, kuderedzwa kwesimba rekurovedza muviri, uye mitochondrial dysfunction mumatishu akawanda. Taurine supplementation inoderedza mitochondrial redox kushushikana, inovandudza kurovedza muviri, uye inodzvinyirira uremu hwemuviri.

Iyo biochemistry uye enzymology yetaurine metabolism yakwezva kufarira kukuru kwekutsvaga. Mune endogenous taurine biosynthetic nzira, cysteine ​​​​inogadziriswa ne cysteine ​​​​dioxygenase (CDO) uye cysteine ​​​​sulfinate decarboxylase (CSAD) kuti igadzire hypotaurine, iyo inozove Oxidation neflavin monooxygenase 1 (FMO1) inogadzira taurine. Pamusoro pezvo, cysteine ​​​​inogona kugadzira hypotaurine kuburikidza neimwe nzira yecysteamine uye cysteamine dioxygenase (ADO). Kudzika kwetaurine pachayo kune akati wandei echipiri taurine metabolites, kusanganisira taurocholate, tauramidine, uye N-acetyl taurine. Iyo chete enzyme inozivikanwa kukonzeresa idzi nzira dzepasi iBAAT, iyo inosanganisa taurine nebile acyl-CoA kugadzira taurocholate uye mamwe bile munyu. Pamusoro peBAAT, iwo mamorekuru ekuzivikanwa kwemamwe ma enzymes anopindirana yechipiri taurine metabolism haisati yatemwa.

N-acetyltaurine (N-acetyl taurine) inonyanya kunakidza asi isina kunyatsodzidza yechipiri metabolite yetaurine. N-acetyl taurine mazinga muzvinyorwa zvipenyu zvinodzorwa zvine simba neakawanda physiological perturbations inowedzera taurine uye/kana acetate flux, kusanganisira kutsungirira kurovedza muviri, kunwa doro, uye zvinovaka muviri taurine yekuwedzera. Pamusoro pezvo, N-acetyltaurine ine kemikari yemaitiro akafanana kune kusaina mamorekuru anosanganisira neurotransmitter acetylcholine uye refu-cheni N-fatty acyltaurine inodzora shuga yeropa, zvichiratidza kuti inogonawo kushanda sechiratidzo che metabolite Chigadzirwa chinoshanda. Nekudaro, iyo biosynthesis, kushatisa, uye zvinogona kuita zveN-acetyl taurine zvinoramba zvisina kujeka.

Muchidzidzo chazvino uno, timu yekutsvagisa yakaratidza PTER, nherera enzyme yebasa risingazivikanwe, seyakanyanya mammalian N-acetyl taurine hydrolase. In vitro, recombinant PTER yakaratidza yakatetepa substrate renji uye mikuru mipimo. MuN-acetyl taurine, inogadzirwa nehydrolyzed kuita taurine uye acetate.

Kugogodza iyo Pter gene mumakonzo kunoguma nekurasikirwa kuzere kweN-acetyl taurine hydrolytic chiitiko mumatissue uye systemic kuwedzera muN-acetyl taurine zvemukati mumatishu akasiyana.

PTER locus yemunhu inosanganiswa nebody mass index (BMI). Chikwata chekutsvagisa chakawedzera kuti mushure mekusimudzira nekuwedzera mazinga etaurine, Pter knockout mbeva dzakaratidza kudzikiswa kwekudya uye dzaipokana nekufutisa-kunokonzerwa nekudya. uye yakagadziridzwa glucose homeostasis. Kuwedzerwa kweN-acetyl taurine kune akafuta-mhando mbeva zvakare yakaderedza kudya kwekudya uye uremu hwemuviri nenzira inotsamira paGFRAL.

Aya data anoisa PTER pamusimboti enzyme node yetaurine yechipiri metabolism uye inoratidza mabasa ePTER uye N-acetyl taurine mukudzora uremu uye chiyero chesimba.

Pakazere, chidzidzo ichi chakawana yekutanga acetyl taurine hydrolase mumhuka dzinoyamwisa, PTER, uye yakasimbisa basa rakakosha reacetyl taurine mukuderedza kudya uye anti-kufutisa. Mune ramangwana, zvinotarisirwa kuti ane simba uye anosarudza PTER inhibitors achagadzirwa kuitira kurapwa kwekufutisa.