Mumakore achangopfuura, urolithin B yekuwedzera yakave yakanyanya kufarirwa kune yavo inogona kubatsira hutano, kusanganisira kusimudzira hutano hwemhasuru, hupenyu hurefu, uye kugara zvakanaka. Sezvo kudiwa kweUrolithin B yekuwedzera kuri kuramba kuchikura, zvakakosha kuti uwane mugadziri akavimbika anopa zvigadzirwa zvemhando yepamusoro. Nezvakawanda sarudzo kunze uko, zvinogona kunetsa kuona kuti ndevapi vagadziri vanovimbika uye kugadzira zvekuwedzera zvinosangana nezvinodiwa. Kuwana yakavimbika urolithin B yekuwedzera mugadziri kunoda kunyatsotarisisa mukurumbira wavo, maitiro ekudzora mhando, kutevedza kwemitemo, pachena, uye kutsvagisa nekusimudzira kugona.
Rwendo rweurolithin runotanga nekudya chikafu chakapfuma mu ellagic acid, senge matamba, sitirobheri, raspberries, uye walnuts. Kana yangopinzwa, ellagic asidhi inosangana neyakatevedzana shanduko mumuviri, pakupedzisira ichigadzira urolithins. Vatambi vakakosha mune iyi maitiro ndeye gut microbiota uye neyake muridzi cellular muchina.
Kamwe mune digestive system, ellagic acid inosangana nenharaunda dzakasiyana siyana dzehutachiona mumatumbu. Mamwe mabhakitiriya ane kugona kunoshamisa kumisa ellagic acid kune urolithins. Uku kutendeuka kwehutachiona inhanho yakakosha mukugadzirwa kweurolithin nekuti muviri wemunhu hauna enzyme inodiwa kushandura ellagic acid yakananga muurolithin.
Kana iyo gut microbiota yaburitsa urolithin, inonyudzwa muropa uye yoendeswa kune akasiyana matishu uye nhengo mumuviri wese. Mukati memasero, urolithins inoita mhedzisiro yadzo nekuita muitiro unonzi mitophagy, unosanganisira kubviswa kwemitochondria yakakuvadzwa (simba resero). Uku kumutsiridzwa kwehutano hwemaserura kwakabatana neanogona mabhenefiti mukushanda kwemhasuru, kutsungirira, uye hupenyu hurefu.
Kugadzirwa kweurolithins mumuviri kunokanganisa kwete chete nekudya kwekudya asiwo nemusiyano wega wega mukuumbwa kweiyo intestinal microbiota. Tsvagiridzo inoratidza kuti kugona kugadzira urolithins kubva ku ellagic acid kunogona kusiyana pakati pevanhu zvichienderana nekwavo yakasarudzika nharaunda hutachiona. Izvi zvinoratidzira kuwirirana kwakaoma pakati pekudya, gut microbiota uye kugadzirwa kwebioactive komisheni mumuviri.
Uyezve, kugadzirwa kweurolithin kunogona kudzikira nezera sekuumbwa kwegut microbiota uye metabolic maitiro anochinja.
Urolithin Bmusanganiswa wechisikigo wakatorwa kubva ku ellagic acid, polyphenol inowanikwa mune mimwe michero nenzungu. Inogadzirwa negut microbiota kuburikidza nemetabolism ye ellagitannins, iyo yakawanda muzvokudya zvakaita semapomegranati, mastrawberries, uye raspberries. Tsvagiridzo inoratidza kuti urolithin B ine masimba ekurwisa kuchembera, zvichiita kuti ive mumiriri anovimbisa kuti abatanidzwe muzvekudya zvakagadzirirwa kusimudzira hupenyu hurefu uye hutano hwese.
Imwe yenzira dzakakosha iyourolithin B inorwisa-kuchembera mhedzisiro ndeye activate nzira inonzi mitophagy.Mitophagy ndiyo nzira yemuviri yemusikirwo yekubvisa yakakuvara kana kusashanda mitochondria, masero 'anogadzira simba. Sezvo isu tichikura, kushanda kwemitophagy kunodzikira, zvichitungamira mukuunganidzwa kwemitochondria yakakuvadzwa uye kudzikira kwesero basa. Urolithin B yakaratidzwa kusimudzira mitophagy, nekudaro ichikurudzira kubviswa kwemitochondria yakakuvadzwa uye kutsigira hutano hwesero.
Pamusoro pekusimudzira mitophagy, urolithin B inewo yakasimba antioxidant uye anti-inflammatory properties. Oxidative kusagadzikana uye kusingaperi kuzvimba ndiwo maviri akakosha madhiraivha ekuchembera, zvichitungamira mukukura kwezvirwere zvine chekuita nezera uye kuderera kwekushanda kwemuviri. Nekutsvaira ma radicals emahara uye kuderedza zviratidzo zvekuzvimba, urolithin B inobatsira kuchengetedza maseru nematishu kubva kune zvinokuvadza zvinokonzerwa nekuchembera, nekudaro zvinosimudzira hutano hwese uye simba.
Iko kugona kweurolithin B yekuwedzera kutsigira kuchembera kune hutano yanga iri nyaya yeakawanda preclinical uye yekiriniki zvidzidzo. Muchidzidzo chinokosha chakabudiswa mumagazini inonzi Nature Medicine, vatsvakurudzi vakaratidza kuti urolithin B yekuwedzera yakavandudza kushanda kwemhasuru uye kutsungirira mumakonzo akwegura. Izvi zvakawanikwa zvakakonzera kufarira kugona kweurolithin B kutsigira hutano hwetsandanyama uye basa remuviri kune vakura, zvichipa nzira inovimbisa yekurwisa kuderera kwemhasuru ine zera uye kushaya simba.
Pakazere, urolithin B yekuwedzera inokwanisa kusimudzira mitophagy, kurwisa oxidative kusagadzikana, uye kuderedza kuzvimba, ichipa inovimbisa nzira yekugadzirisa ari pasi pematanho ekuchembera padanho remasero. Sezvo tsvakiridzo munharaunda iyi ichienderera mberi, urolithin B inogona kuve chishandiso chakakosha mukutsvaga hupenyu hurefu uye hupenyu, ichipa humbowo hutsva hwebasa rezvekudya zvekuwedzera mukuchembera kune hutano.
1. Kuvandudza mitochondrial basa
Inowanzo kunzi simba resero, mitochondria inoita basa rakakosha mukugadzira simba remuviri. Urolithin B yakawanikwa inokurudzira hutano hwemitochondrial uye basa, nekudaro ichiwedzera kugadzirwa kwesimba uye huwandu hwesero simba. Nekutsigira mitochondrial basa, urolithin B inogona kubatsira kurwisa mhedzisiro yekuchembera uye kubatsira kuwedzera mazinga esimba uye simba rose.
2. Utano Hwetsandanyama uye Kudzorerwa
Kune vanhu vari kushanda kana kurovedza muviri nguva dzose, urolithin B inogona kupa zvakakosha zvehutano hwehutano uye kupora. Tsvagiridzo inoratidza kuti urolithin B inobatsira kukurudzira kukura kwemhasuru uye kusimba uye inobatsira mukupora kwetsandanyama mushure mekuita basa rakaoma remuviri. Izvi zvinoita kuti ive yekuwedzera inoyevedza yevamhanyi uye vanofarira kusimba vanotarisa kukwiridzira kuita uye kupora.
3. Anti-inflammatory properties
Kuzvimba ndiwo maitiro emuviri ekudzivirira kubva mukukuvadzwa uye kutapukirwa. Zvisinei, kuzvimba kusingaperi kunogona kutungamirira kumatambudziko akasiyana-siyana ehutano. Urolithin B yakawanikwa iine anti-inflammatory properties inogona kubatsira kuderedza kuzvimba uye kutsigira basa rose rekudzivirira zvirwere. Nekugadzirisa kuzvimba, urolithin B inogona kubatsira kune hutano hwekuzvimba mhinduro uye kubatsira kudzivirira zvimwe zvirwere zvisingaperi.
4. Kucheneswa kweSero uye Autophagy
Autophagy maitiro emuviri echisikigo ekubvisa akakuvadzwa kana kusashanda maseru kuitira kuti masero matsva, ane hutano agone kuvandudzwa. Urolithin B yakaratidzwa kutsigira autophagy, kukurudzira kucheneswa kwemasero uye kubviswa kwemarara emasero. Iyi nzira yakakosha pakuchengetedza hutano hweserura uye inogona kuita basa mukurarama kwenguva refu nekudzivirira zvirwere.
5. Kuziva hutano uye kushanda kwehuropi
Tsvagiridzo inoratidza kuti urolithin B inogona kubatsira kudzivirira kuderera kwekuziva kwakabatana nezera uye kutsigira hutano hwehuropi hwese. Nekusimudzira neuronal basa uye kudzivirira kubva kune oxidative kusagadzikana, urolithin B inoratidza chivimbiso mukutsigira kugona kwekuziva uye kujeka kwepfungwa.
6. Gut Health uye Microbiome Support
Iyo gut microbiome inoita basa rakakosha muhutano hwese, inokanganisa kugaya, immune immune, uye kunyangwe hutano hwepfungwa. Zvidzidzo zvakawana kuti urolithin B inotsigira hutano hwematumbo nekusimudzira hutano hwehutachiona hwehutachiona uye nekusimudzira microbiome inobudirira. Izvi zvinogona kukanganisa zvakanyanya hutano hwese uye zvinogona kubatsira kuvandudza kugaya uye immune function.
7. Kurarama kwenguva refu uye Kuchembera
Chimwe chezvinhu zvinonyanya kufadza zveurolithin B ibasa rayo rinogona kuita mukusimudzira hupenyu hurefu uye kuchembera kune hutano. Nekutsigira hutano hweserura, basa remitochondrial, uye autophagy, urolithin B inogona kubatsira mukukwanisa kwemuviri kuchengetedza basa rakakwana panguva yekukwegura. Izvi zvakamutsa kufarira muurolithin B seyakakwanisa kurwisa kuchembera ine mukana wekutsigira hupenyu hwese uye kugara zvakanaka patiri zera.
Sezvo urolithin B inokura mukuzivikanwa sechinhu chinogona kurwisa kuchembera uye mhasuru yekuwedzera hutano, zvakakosha kuti unzwisise zvinhu zvakakosha zvekufunga kana uchisarudza yakanakisa urolithin B yekuwedzera kune zvaunoda.
1. Hunhu uye Kuchena
Paunosarudza urolithin B yekuwedzera, zvakakosha kukoshesa kunaka uye kuchena. Tarisa ma supplements anogadzirwa nemhando yepamusoro-soro uye akaedzwa zvakasimba kuchena uye kushanda. Kusarudza mhando ine mukurumbira inoteedzera yakaomesesa yekugadzira zviyero kunovimbisa kuti uri kuwana yakachengeteka uye inoshanda chigadzirwa.
2. Dose uye kuisa pfungwa
Iyo dosage uye kusungirirwa kweurolithin B mune zvekuwedzera zvinogona kusiyana zvakanyanya pakati pezvigadzirwa zvakasiyana. Pakusarudza muyero wakakukodzera, zvakakosha kuti utarise zvinangwa zvako zvehutano uye zvaunoda. Kubvunza nyanzvi yezvehutano kana kutevedzera dosi yakakurudzirwa pane chigadzirwa label kunogona kukubatsira kuona dosi yeurolithin B inokodzera zvaunoda iwe pachako.
3. Formula uye nzira yekutonga
Urolithin B yekuwedzera inowanikwa mumhando dzakawanda, kusanganisira macapsules uye hupfu. Chimiro chega chega chinogona kunge chine mazinga akasiyana ekunyura uye bioavailability. Paunenge uchisarudza yakanakisa yekugadzira uye dosing nzira yeurolithin B yekuwedzera, funga zvaunofarira wega uye mararamiro.
4. Brand pachena uye mukurumbira
Kana zvasvika kune zvekuwedzera, pachena uye mukurumbira wemhando yakakosha. Tsvaga kambani inopa ruzivo rwakajeka nezve kutsvagisa, kugadzira, uye kuyedzwa kweurolithin B yekuwedzera. Pamusoro pezvo, funga nezvemukurumbira wechigadzirwa, kuongororwa kwevatengi, uye chero zvitupa kana yechitatu-bato kuyedzwa iyo inogona kupupurira kunaka kwechigadzirwa uye kuvimbika.
1. Tsvakurudza mukurumbira wemugadziri
Paunenge uchitsvaga yakavimbika urolithin B yekuwedzera mugadziri, zvakakosha kuti uite tsvakiridzo yakakwana pamusoro pemukurumbira wekambani. Tarisa vagadziri vane rekodhi rekodhi yekugadzira yepamusoro-mhando yekuwedzera uye kuomerera kune yakasimba yemhando yekudzora matanho. Zvakare, tarisa kana mugadziri aine chero zvitupa kana kubvumidzwa kubva kumasangano ane mukurumbira, sezvo izvi zvichigona kuratidza kuzvipira kwavo kune mhando nekuchengeteka.
2. Kudzora Kwehutano uye Kuedza Maitiro
Vagadziri vane mukurumbira urolithin B yekuwedzera vanozove neakasimba emhando yekudzora uye maitiro ekuyedza kuona kuchena uye simba rezvigadzirwa zvavo. Bvunza nezvematanho ekudzora emhando yemugadziri, kusanganisira mabviro avanoita zvinhu zvakabikwa, maitiro ekugadzira avanoshandisa, uye nzira dzekuyedza dzinoshandiswa kuratidza chokwadi uye kushanda kwekuwedzera. Vagadziri vari pachena nezvemaitiro avo ekutonga kwemhando uye vanoda kupa ruzivo rwakadzama vanogona kuve vakavimbika uye vakavimbika.
3. Teerera nemitemo yemitemo
Paunenge uchisarudza mugadziri weurolithin B wekuwedzera, unofanirwa kuve nechokwadi chekuti vanoteedzera zviyero uye nhungamiro dzakatarwa nemasangano akakodzera. Tarisa kuti vagadziri vanotevera maitiro akanaka ekugadzira (GMP) uye kuti zvivakwa zvavo zvinoongororwa nguva nenguva nemasangano anodzora. Kutevedzera zviyero izvi kwakakosha pakuona kuchengetedzeka, mhando, uye kushanda kwezvekuwedzera. Pamusoro pezvo, tarisa kuti uone kana zvigadzirwa zvemugadziri zvakayedzwa nevechitatu-bato lab kuti vaone zvavanotaura uye kuona kuti hazvina zvinosvibisa.
4. Kujeka uye kutaurirana
Kukurukurirana kwakavhurika uye kwakajeka kwakakosha pakubata nevagadziri vekuwedzera urolithin B. Vagadziri vanovimbika vanozopa ruzivo nezve chigadzirwa chavo nekukasira, kusanganisira izvo zvinosanganisa, maitiro ekugadzira, uye chero tsvakiridzo yakakodzera kana zvidzidzo zvinotsigira kushanda kweurolithin B yekuwedzera. Vanofanirawo kupindura kune kubvunza uye kuda kugadzirisa chero kunetseka kana mibvunzo yaungave uine. Vagadziri vanobuda pachena uye vanotaurirana vanogona kukoshesa kugutsikana kwevatengi uye kunaka kwechigadzirwa.
5. Tsvagiridzo nekusimudzira kugona
Mugadziri ane mukurumbira weUrolithin B wekuwedzera achaisa mari mukutsvagisa nekusimudzira kuti varambe vachivandudza zvigadzirwa zvavo uye varambe vari pamberi mukufambira mberi kwesainzi. Bvunza nezve mugadziri weR&D kugona, kusanganisira chero tsvakiridzo inoenderera mberi kana kubatana nenyanzvi mumunda. Vagadziri vakazvipira kusimudzira sainzi kuseri kweurolithin B yekuwedzera vane mukana wekugadzira zvigadzirwa zvitsva uye zvinoshanda.
Suzhou Myland Pharm & Nutrition Inc. yave ichiita bhizinesi rekuwedzera chikafu kubva muna 1992. Ndiyo kambani yekutanga muChina kugadzira nekutengesa mhodzi dzemazambiringa.
Iine makore makumi matatu echiitiko uye ichitungamirwa nehunyanzvi hwepamusoro uye yakagadziridzwa zvakanyanya R&D zano, kambani yakagadzira mhando yezvigadzirwa zvemakwikwi uye ikava yekuvandudza hupenyu hwesainzi yekuwedzera, yetsika synthesis uye kambani yekugadzira masevhisi.
Pamusoro pezvo, Suzhou Myland Pharm & Nutrition Inc. zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvazvino uye zvinoshanda uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye magadzirirwo ekugadzira GMP.
Mubvunzo: Ndezvipi zvinobatsira zveUrolithin B zvinowedzera?
A: Urolithin B zvinowedzera zvinotendwa kuti zvinopa hutano huzhinji hunobatsira, kusanganisira kutsigira hutano hwemitochondrial, kukurudzira kushanda kwemhasuru, kubatsira mukuvandudzwa kwemasero, zvinogona kutsigira hupenyu hurefu, uye kuratidza antioxidant zvinhu.
Mubvunzo: Urolithin B inobatsira sei kuhutano hwemitochondrial?
A: Urolithin B inofungidzirwa kutsigira hutano hwemitochondrial kuburikidza nekuita nzira inonzi mitophagy, iyo inobatsira kubvisa mitochondria yakakuvadzwa uye kukurudzira chizvarwa chemitochondria itsva, ine utano. Iyi nzira yakakosha pakugadzirwa kwesimba remagetsi uye hutano hwesero.
Mubvunzo: Ndeipi basa rinoitwa neUrolithin B mukushanda kwemhasuru uye kupora?
A: Urolithin B inogona kutsigira mhasuru kushanda uye kupora nekusimudzira tsandanyama protein synthesis, inogona kuderedza kuzvimba kwetsandanyama, uye kubatsira mukugadzirisa uye kumutsiridza tsandanyama mushure mekurovedza muviri kana kuita zvemuviri.
Mubvunzo: Urolithin B inobatsira sei mukuvandudza masero?
A: Urolithin B inotendwa kuti inobatsira mukuvandudzwa kwemasero kuburikidza nekugadzirisa nzira dzemagetsi dzine chokuita nehupenyu hurefu uye hutano hwemaserura. Inogona kubatsira kukurudzira kubviswa kweakakuvadzwa maseru zvikamu uye kutsigira kuvandudzwa kwemasero ane hutano.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Jul-05-2024
