Munyika ine nutraceutical, nicotinamide riboside chloride (NRC) yakagamuchira kutariswa kwakapararira kune zvayakanakira mukusimudzira hutano hweserura uye hupenyu hurefu. Nekudaro, nemusika wakazara nemhando uye magadzirirwo, kusarudza yemhando yepamusoro NRC poda inogona kutyisa. Kusarudza mhando nicotinamide riboside chloride poda pakutanga kunoda kunyatsotarisisa kuchena, kuumbwa, mhinduro yemutengi, uye mutengo. Nekuisa pamberi zvinhu izvi, unogona kusarudza zvakanangwa zvigadzirwa zvinotsigira uye zvakachengeteka bhizinesi rako.
Nicotinamide riboside chloride ndiyo chloride munyu fomu ye nicotinamide riboside (NR). NR inyowani pyridine nucleoside yevhitamini B3 inoshanda seyakatangira nicotinamide adenine dinucleotide (NAD) kana NAD+. Nicotinamide riboside chloride ndiyo crystalline fomu ye nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride inowedzera NAD[+] mazinga uye inomutsa SIRT1 uye SIRT3, pakupedzisira inosimudzira oxidative metabolism uye kudzivirira metabolic abnormalities kunokonzerwa nekudya-mafuta akawanda. Nicotinamide riboside chloride inoshandiswa mune zvekudya zvinowedzera.
Nicotinamide riboside chloride ndiyo fomu inowanzo shandiswa mukuwedzera uye ishanduro yakagadzikana yeNR. Iyo chloride munyu fomu inosimudzira kugadzikana uye bioavailability yeNR, zvichiita kuti kuwedzera kwayo kushande. Nicotinamide Riboside Chloride inogadzirwa kuti ive nechokwadi chekuenderana, kuchena, uye potency iyo yakakosha pakuita kwayo uye kuchengeteka.
NR imhando yevhitamini B3 (niacin) uye inotangiranicotinamide adenine dinucleotide (NAD+),kiyi coenzyme inowanikwa mumasero mapenyu ese uye yakakosha kuhupenyu. Iyo dinucleotide, zvinoreva kuti ine nucleotide mbiri dzakabatanidzwa neboka rephosphate. Imwe nucleotide ine adenine base uye imwe yacho ine nicotinamide. NAD + ndeimwe yemamorekuru anosiyana-siyana mumuviri uye nzvimbo yakakosha yekutsvagisa kuchembera.
NAD+ ndiyo mafuta kune akawanda akakosha biological process:
1. Shandura zvinovaka muviri kuita simba
2. Gadzirisa DNA kukanganisa
3. Simbisa hurongwa hwekudzivirira sero
4. Regulate circadian rhythm
Nehurombo, patinenge tichikura, mazinga eNAD + anodzikira, achisiya simba shoma rekuita kweserura. Izvi zvinogona kukonzera kukura kwezvirwere zvakasiyana-siyana zvinoenderana nezera senge chirwere cheshuga,
Kuteedzera huwandu hweNR hunoitika zvakasikwa mune zvimwe zvekudya. Mukaka, mbiriso, uye zvimwe zvekudya zvine NR, asi mune zvishoma. Semuyenzaniso, mukaka une NR, asi unofanirwa kushandisa huwandu hwakakura kuti usvike pamazinga anoshandiswa muzvidzidzo zvekiriniki. Naizvozvo, kunyangwe NR ichiitika zvakajairika, kuwana huwandu hukuru hweNR kuburikidza nekudya chete kunonetsa.
Zvichipa kuoma kwekuwana NRC yakakwana kubva kune zvakasikwa, nzira dzekugadzira NRC dzakagadzirwa. Kugadzirwa kwekugadzira kweNRC kunosanganisira nhevedzano yemaitiro emakemikari anoshandura zvinhu zvekutanga kuita zvinodikanwa. Iyi nzira inogona kuburitsa huwandu hwakakwana hweNRC hwekutsvagisa uye kuzadzazve.
Nicotinamide riboside (NR) imhando yevhitamini B3, inozivikanwawo se niacin. Ndiyo inotangira nicotinamide adenine dinucleotide (NAD+), coenzyme iripo mumasero mapenyu ese uye inoita basa rakakosha musimba remetabolism uye kugadzirisa masero. basa rinokosha. NAD + mazinga anowanzo kuderera nezera, zvichikonzera kudzikira kwesero kushanda uye nengozi yekuwedzera yezvirwere zvine chekuita nezera. Nicotinamide riboside chloride imhando yakagadzikana yeNR uye inowanzo shandiswa mune zvekudya zvinowedzera kuwedzera NAD + mazinga mumuviri.
Kuderera kweNAD + mazinga chiratidzo chekuchembera uye kwakabatana nehuwandu hwezvirwere zvine hukama nezera, zvinosanganisira metabolic kusagadzikana, neurodegenerative chirwere, uye matambudziko emoyo. Nekuwedzera NAD + mazinga, NRC ine mukana wekuvandudza sero kushanda uye kukurudzira kuchembera kune hutano. Hedzino dzimwe dzenzira dzakakosha dzeNRC dzinogona kukanganisa kuchembera:
1. Inovandudza kugadzirwa kwesimba remagetsi: NAD + yakakosha pakushanda kwemitochondria, masimba emasero anogadzira simba. Nekuwedzera NAD + mazinga, NR inosimudzira mitochondrial basa, nekudaro ichiwedzera kugadzirwa kwesimba nekuvandudza hutano hweserura.
2. Kugadziriswa nekugadzirisa DNA: NAD + chinhu chinokosha chekugadzirisa DNA. Kuunganidzwa kwekukuvara kweDNA nezera kunogona kukonzera kusashanda kwemasero uye kukura kwezvirwere zvine chekuita nezera. NR yekuwedzera inogona kutsigira nzira dzekugadzirisa DNA, zvichibatsira kuchengetedza kugadzikana kwegenomic uye kuderedza njodzi yechirwere.
3. Sirtuin Activation: Sirtuins imhuri yemapuroteni anoita basa rinokosha mukugadzirisa hutano hwemaserura uye hupenyu. NAD + inodikanwa kumisa Sirtuins, nekudaro ichikurudzira kugadzirisa masero, anti-stress uye metabolic regulation. Nekuwedzera NAD + mazinga, NR inogona kuwedzera sirtuin chiitiko uye kutsigira kuchembera kune hutano.
Preclinical zvidzidzo mumhando dzemhuka zvinoratidza kuti NR yekuwedzera inogona kuwedzera hupenyu, kuvandudza hutano hwemetabolism, uye kuwedzera kugona kwekuziva. Miedzo yekiriniki yevanhu yakaratidzawo mhedzisiro inovimbisa, neNR yekuwedzera inowedzera NAD+ mazinga, kuvandudza metabolic hutano mamaki, uye inosimudzira kuita kwemuviri.
Chidzidzo chinozivikanwa chakabudiswa mupepanhau Cell Metabolism chakawana kuti NR supplementation muvakuru vakuru yakawedzera zvakanyanya NAD + mazinga uye yakagadziridzwa mhasuru kushanda uye kutsungirira. Imwe ongororo yakaburitswa muNature Communications yakashuma kuti NR yekuwedzera yakavandudza cognitive basa uye yakaderedza neuroinflammatory mamakisi mune mbeva modhi yechirwere cheAlzheimer.
1. Kurudzira kugadzirwa kwesimba remagetsi
Pamwoyo wemasero edu pane mitochondria, inowanzonzi "dzimba dzesimba" dzesero. Aya organelles ane basa rekugadzira adenosine triphosphate (ATP), iyo sero yekutanga simba mari. Nicotinamide riboside chloride inoita basa rakakosha mukuita uku nekuwedzera mazinga e nicotinamide adenine dinucleotide (NAD+), coenzyme yakakosha pakuita mitochondrial.
NAD+mazinga anowanzodzikira patinenge takura, zvichikonzera kudzikiswa kwekugadzirwa kwesimba remagetsi uye kuwedzera kuneta. Kuwedzera neNRC kunobatsira kudzoreredza NAD + mazinga, nekudaro kusimudzira mitochondrial basa nekuvandudza kugadzirwa kwesimba rose. Izvi zvinovandudza kushanda kwemuviri, kunoderedza kuneta uye kunowedzera simba.
2. Tsigira kukwegura kwakanaka
Tsvagiridzo inoratidza kuti kuchengetedza yakakwana NAD + mazinga kwakakosha kuhupenyu hurefu uye hutano hwese. NAD + inobatanidzwa mumhando dzakasiyana dzemaserura, kusanganisira kugadzirisa kweDNA, gene expression, uye cellular stress mhinduro.
Nekuwedzera NAD + mazinga, NRC inogona kubatsira kuchengetedza maseru kubva mukukuvadzwa, kukurudzira kugadzirisa kweDNA, uye kutsigira nzira dzekudzivirira dzemuviri kudzivirira kudzikira zvine chekuita nezera. Izvi zvinogona kuvandudza hutano hweganda, kuderedza zviratidzo zvekuchembera, uye kuderedza njodzi yezvirwere zvine chekuita nezera senge Alzheimer's uye Parkinson's disease.
3. Kuvandudza basa rekuziva
Kudzikira kwekuziva idambudziko rakajairika sezvatinokura, asi nicotinamide riboside chloride inogona kupa mhinduro. NAD + yakakosha kune hutano hwehuropi nekuti inotsigira neuron mashandiro, inodzivirira kubva kune neurodegeneration, uye inosimudzira kugadzirwa kwemaurotransmitter. Kuwedzera neNRC kunogona kuvandudza kugona kwekuita, kuwedzera ndangariro, uye kudzivirira kuderera kwekuziva kwakabatana nezera. Nekuwedzera NAD + mazinga, NRC inobatsira kuchengetedza hutano uye kushanda kwemasero ehuropi, nekudaro inovandudza kujeka kwepfungwa, kutarisisa, uye kuita kwekuziva kwese.
4. Kurudzira hutano hwemetabolism
Hutano hwemetabolic chinhu chakakosha chehutano hwese, uye nicotinamide riboside chloride yakaratidzwa kuve ine mhedzisiro yakanaka pametabolism. NAD + inobatanidzwa mune dzakasiyana siyana metabolic maitiro, anosanganisira glucose uye lipid metabolism, insulin senitivity, uye kushandisa simba. Kuwedzera neNRC kunogona kuvandudza hutano hwemetabolism nekuwedzera NAD + mazinga, nekudaro kuwedzera basa remakiyi metabolic nzira. Izvi zvinogona kuvandudza kudzora shuga yeropa, kuderedza njodzi yezvirwere zvemetabolism senge chirwere cheshuga, uye kubvumira kuti uremu huve nani.
5. Tsigira utano hwemwoyo
Hutano hwemoyo ndeimwe nzvimbo yekutarisa nicotinamide riboside chloride. NAD + inoita basa rakakosha mukuchengetedza hutano uye kushanda kweiyo yemoyo system, kusanganisira moyo netsinga. Kuwedzera NRC kunogona kuvandudza hutano hwemoyo nekuwedzera NAD + mazinga, ayo anobatsira kudzivirira oxidative kusagadzikana, kuzvimba, uye endothelial dysfunction. Izvi zvinovandudza kuyerera kweropa, zvinoderedza njodzi yechirwere chemoyo, uye zvinovandudza hutano hwemoyo wese.
NRC inoshandurwa kuita NAD+ kuburikidza nenhevedzano ye biochemical reaction. Maitiro aya anoshanda zvakanyanya kana achienzaniswa nemamwe maNAD+ precursors akadai niacin uye nicotinamide. Tsvagiridzo inoratidza kuti NRC yekuwedzera inogona kuwedzera zvinobudirira mazinga eNAD +, zvichikonzera kuvandudza mitochondrial basa, kuwedzera simba rekugadzira uye zvirinani kugadzirisa maseru.
NR inofananidzwa sei nemamwe ma supplements
1. NR vs. Traditional Vitamin B3 Supplements
Echinyakare vhitamini B3 yekuwedzera senge niacin uye niacinamide yakashandiswa kwemakumi emakore kutsigira hutano hwemoyo uye kudzikisa cholesterol mazinga. Zvisinei, vanewo zvimwe zvazvakaipira. Semuyenzaniso, niacin inogona kukonzera flushing, yakajairika side effect inoratidzwa nekutsvuka uye kudziya kweganda. Niacinamide, kune rimwe divi, haikonzeredze kuyerera, asi hainyanyi kushanda pakusimudza NAD + mazinga pane NRC.
NRC inomira pachena seimwe nzira yepamusoro nekuda kwekugona kwayo kunyatso wedzera NAD + mazinga pasina kukonzera zvisingafadzi mhedzisiro ine chekuita neniacin. Izvi zvinoita kuti NRC ive yakanyanya kunaka sarudzo kune avo vari kutsvaga mabhenefiti evhitamini B3 pasina zvinokanganisa.
2. NR uye Coenzyme Q10 (CoQ10)
Coenzyme Q10 (CoQ10) chimwe chekuwedzera chakakurumbira chinozivikanwa nebasa rayo mukugadzira simba uye antioxidant zvivakwa. Coenzyme Q10 yakakosha kune basa remitochondria, dzimba dzesimba dzesero. Nepo CoQ10 yekuwedzera inogona kutsigira hutano hwemitochondrial uye kurwisa oxidative kusagadzikana, haikanganisi zvakananga NAD + mazinga.
NRC, kune rumwe rutivi, inowedzera zvakananga NAD + mazinga, nekudaro inosimudzira mitochondrial basa uye kugadzirwa kwesimba. Nekuwedzera mazinga eNAD +, NRC inopa nzira yakazara yehutano hweserura uye simba metabolism kupfuura CoQ10 chete.
3. NRC uye Resveratrol
Resveratrol inonzi polyphenol inowanikwa muwaini tsvuku, mazambiringa uye mamwe mabriji. Iyo inozivikanwa nekuda kwayo antioxidant uye anti-inflammatory properties. Resveratrol yakakurumbira nekuda kwekugona kwayo kuita sirtuins, mhuri yemapuroteni ane hukama nehutano hweserura uye hupenyu hurefu. Nekudaro, resveratrol ine yakaderera bioavailability, zvichireva kuti chikamu chidiki chete chemukomboni wakamwiswa chinotorwa uye chinoshandiswa nemuviri.
Nekuwedzera NAD + mazinga, NRC zvakare inomutsa sirtuins, nekudaro ichisimudzira mabhenefiti akafanana kune resveratrol. Pamusoro pezvo, NR's yepamusoro bioavailability inoita kuti chikamu chepamusoro chekuwedzera chinyatso shandiswa nemuviri, zvichiita kuti ive sarudzo inoshanda yekutsigira hutano hweserura uye hupenyu hurefu.
4. NRC uye Antioxidant Supplements
Antioxidant supplements, yakadai sevhitamini C, vhitamini E, uye glutathione, inoshandiswa zvakanyanya kurwisa oxidative kusagadzikana uye kudzivirira maseru kubva mukukuvadzwa. Nepo aya maoxidants achiita basa rakakosha mukudzikamisa mahara radicals, haagadzirise kudzikira kwakadzika muNAD + mazinga ane chekuita nekuchembera.
NRC ine mukana wakasarudzika wekusangotsigira antioxidant dziviriro, asiwo kuwedzera NAD + mazinga, ayo akakosha pakugadzirisa masero uye kugadzirisa. Nekugadzirisa oxidative kusagadzikana uye NAD + kuderera,NRC inopa nzira yakazara yekusimudzira hutano hwese uye hupenyu hurefu.
Sei kunaka kwakakosha
Kubudirira kweNRC yekuwedzera kunoenderana zvakanyanya nemhando yayo. Zvigadzirwa zvemhando yakaderera zvinogona kuve netsvina, kuve yakaderera-doro, kana kuve nemishonga isingashande inodzikisira mabhenefiti azvo kana kukuvadza. Naizvozvo, kuisa mari mumhando yepamusoro nicotinamide riboside chloride poda kwakakosha kuti uwane hutano hunodiwa.
Zvinhu zvinokosha zvokufunga nezvazvo
1. Kuchena uye Potency
Kuchena kweNicotinamide Riboside Chloride poda kwakakosha. Tsvaga zvigadzirwa zvinopa yechitatu-bato laboratori Chitupa cheAnalysis (CoA). Gwaro iri rinoona kuchena uye simba rechigadzirwa, richiona kuti rine huwandu hwakatarwa hweNR uye harina zvinosvibisa zvinokuvadza. Sezvineiwo, iyo NR yemukati inofanirwa kunge iri 98% yakachena.
2. Nzvimbo uye Maitiro Ekugadzira
Kunobva zvigadzirwa uye nzira dzekugadzira dzinoshandiswa dzinogona kukanganisa zvakanyanya kunaka kwenicotinamide riboside chloride poda. Sarudza zvigadzirwa zvinobva kune vane mukurumbira vatengesi uye zvinogadzirwa muzvivakwa zvinotevedzera Yakanaka Manufacturing Maitiro (GMP). Aya mazinga anovimbisa kuti zvigadzirwa zvinogadzirwa munzvimbo yakachena, inodzorwa inoderedza njodzi yekusvibiswa.
3. Bioavailability
Bioavailability inoreva chiyero uye chiyero icho chinhu chinoshanda chinotorwa uye kushandiswa nemuviri. Mamwe nicotinamide riboside chloride maumbirwo akagadzirirwa kuwedzera bioavailability, zvichiita kuti inyatsoshanda. Tsvaga zvigadzirwa zvinoshandisa masisitimu ekufambisa epamberi, senge liposome encapsulation kana kusimudzira-kuburitsa tekinoroji, kuti uwedzere kunyura.
4. Additives uye fillers
Mazhinji ekuwedzera ane ekuwedzera uye mafirita anogona kunyungudutsa zvinoshanda zvinosanganisa kana kukonzera kukanganisa. Sarudza nicotinamide riboside chloride poda ine zvidiki kana zvisina zvekuwedzera kuti uone kuti iwe unowana yakachena uye inoshanda chigadzirwa. Kana zvekuwedzera zviripo, zvinofanirwa kunyorwa zvakajeka uye zvakachengeteka kudyiwa.
5. Mukurumbira wechiratidzo uye wongororo
Mukurumbira wechiratidzo unogona kupa ruzivo rwakakosha mumhando yezvigadzirwa zvayo. Tsvakurudza nhoroondo yemhando, ongororo dzevatengi, uye chero zvitupa kana mibairo yayakagamuchira. Mhinduro yakanaka uye kutsigira kubva kune vanovimbwa nenyanzvi dzehutano zvinoratidzawo kuti chigadzirwa chakavimbika.
6. Mutengo uye kukosha
Nepo mutengo usingafanire kunge uri wega wekusarudza, inogona kuve chiratidzo chemhando. Mutengo wakanyanya kuderera wehupfu yerabha inogona kukanganisa kuchena uye potency. Enzanisa mitengo kubva kumhando dzinozivikanwa, uchifunga nezve mutengo pasevhisi uye kukosha kwese. Kuisa mari muchinhu chinodhura zvishoma, chemhando yepamusoro chinogona kuunza mhedzisiro iri nani nekufamba kwenguva.
Matanho Anoshanda eKusarudza Hunhu Nicotinamide Riboside Chloride Powder
Nhanho 1: Tsvagiridzo uye Shortlist
Tanga nekutsvaga akasiyana NRC poda mabhureki uye mafomula. Gadzira rondedzero pfupi yezvigadzirwa zvinosangana nezvinhu zvakakosha zvakanyorwa pamusoro. Shandisa zviwanikwa zvepamhepo senge maforamu ehutano, nzvimbo dzekuongorora, uye zano renyanzvi kuunganidza ruzivo.
Danho 2: Simbisa Kuchena uye Potency
Tarisa uone kana chigadzirwa chakanyorwa chipfupi chinopa CoA kubva kune yechitatu-bato marabhoritari. Simbisa zvemukati zveNRC uye uone kuti zvinosangana nechiyero chehutsanana che98%. Dzivisa zvigadzirwa zvisingaburitse ruzivo urwu.
Danho rechitatu: Ongorora bioavailability
Tsvaga zvigadzirwa zvinotaura bioavailability-enhancing features. Ongorora masisitimu ekutumira anoshandiswa uye kushanda kwawo. Kana zvichibvira, sarudza mafomula akaedzwa nekiriniki kuti atore uye ashande.
Danho 4: Tarisa Additives
Tarisa iyo inongedzo runyorwa kune chero zvisingakoshi zvekuwedzera kana mafirita. Ita shuwa kuti chigadzirwa chine zvidiki kana kuti hazvina zvekuwedzera uye kuti chero zvinhu zvinosanganisirwa zvakachengeteka uye zvakajeka zvakanyorwa.
Danho 5: Enzanisa Mitengo
Enzanisa mitengo yezvinhu zvakapfupikiswa, uchifunga nezve mutengo pasevhisi uye kukosha kwese. Dzivisa zvakachipa zvakachipa zvingakanganisa kunaka. Sarudza zvigadzirwa zvinorova chiyero chakanaka pakati pemhando uye kugona.
Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena nicotinamide riboside chloride poda.
PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yakaedzwa zvakasimba kuchena uye potency, yedu Nicotinamide Riboside Chloride Powder ndiyo sarudzo yakakwana kana iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako, kana kuwedzera hutano hwese.
Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.
Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvazvino uye zvinoshanda-akawanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye magadzirirwo ekugadzira GMP.
Mubvunzo: Chii chinonzi Nicotinamide Riboside Chloride Powder?
A: Nicotinamide riboside chloride (NRC) imhando yevhitamini B3 iyo yakawana mukurumbira nekuda kwehutano hwayo hunogona kubatsira, kunyanya mukutsigira kugadzirwa kwesimba remagetsi uye metabolism. NRC inowanzotengeswa muhupfu, zvichiita kuti zvive nyore kune avo vanosarudza kugadzirisa dosage yavo.
Q; Ndeapi Mabhenefiti eNicotinamide Riboside Chloride Powder?
A: NRC yakadzidzwa kuitira kugona kwayo kutsigira kuchembera kune hutano, kuvandudza mitochondrial basa, uye kuwedzera kutsungirira nekuita. Zvinotendwawo kuti zvinosimudzira hutano hwemoyo uye cognitive basa. Vazhinji vashandisi vanoshuma kuwedzera kwesimba mazinga uye hutano hwese mushure mekubatanidza NRC mumaitiro avo ezuva nezuva.
Q; Ini Ndinosarudza Sei Yemhando yepamusoro Nicotinamide Riboside Chloride Powder?
A: Paunenge uchitenga NRC poda, zvakakosha kuisa pamberi pemhando uye kuchena. Tsvaga mutengesi ane mukurumbira anopa wechitatu-bato kuyedzwa kuti ave nechokwadi chekuti chigadzirwa hachina kusvibiswa uye chinosangana ne potency zviyero. Pamusoro pezvo, funga zvinhu zvakaita sekutsvaga, maitiro ekugadzira, uye ongororo yevatengi kuyera kunaka kwechigadzirwa.
Mubvunzo: Ndekupi Kwandingatenga Nicotinamide Riboside Chloride Powder?
A: NRC poda inowanikwa nyore nyore kubva kune vakasiyana siyana vatengesi vepamhepo, zvitoro zvehutano zvekudya, uye specialty supplement zvitoro. Paunenge uchitenga NRC, koshesa vatengesi vane mbiri vanopa ruzivo rwakajeka nezvezvigadzirwa zvavo, kusanganisira kutsvaga, kuedza, uye rutsigiro rwevatengi.
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Nguva yekutumira: Sep-18-2024
