N-Methyl-DL-Aspartic Acid inhengo yekirasi yeamino acids. Inozivikanwa zvakanyanya nebasa rayo muurobiology, komisheni iyi ianalogi yekugadzira yeaspartate iyo inomutsa N-Methyl-DL-Aspartic Acid receptors muuropi. NMDA receptors inoita basa rakakosha mune akasiyana siyana sisitimu system, kusanganisira kudzidza, ndangariro, uye synaptic plasticity.
Kana iwe uchida kuziva kuti N-Methyl-DL-Aspartic Acid chii, ngatitangei kunzwisisa kuti chii chinonzi amino acid? Amino acid ndiyo yakakosha chikamu cheprotein, uye mapuroteni ndicho chikamu chikuru chezvakasiyana biologically inoshanda zvinhu mumasero emunhu, senge ma enzymes, masoja ekudzivirira chirwere, tsandanyama uye matishu. Kudya kwakaringana kwemaamino acids kunogona kuchengetedza hutano hweprotein synthesis uye kugadzirisa, uye kukurudzira kukura nekugadzirisa kwematishu emuviri.
Amino acids akakosha pakushanda kwakanaka kweakawanda masisitimu uye mabasa mumuviri. Zvinonzwisisika uye zvakakwana kudyiwa kweakasiyana amino acids ndechimwe chezvinhu zvakakosha zvekuchengetedza hutano.
N-Methyl-DL-Aspartic Acid is methylated derivative ye aspartic acid (Astentic Acid) ine methyl boka.
Iyo isomeri yeaspartic acid ine methyl boka rakasungirirwa kuatomu yenitrogen. inonzi amino acid derivative iyo inoshanda seyakananga agonist paNMDA receptors, kutevedzera chiito che glutamate, neurotransmitter iyo inowanzoita pane ino receptor.
N-Methyl-DL-Aspartic Acid iripo mune zvakasiyana-siyana zvipenyu, kusanganisira zvirimwa nemhuka.
Iyo ine chimwe chiitiko chebhaibheri mumuviri mhenyu uye inotora chikamu mune dzakasiyana siyana dzemuviri maitiro, senge synthesis uye kuburitswa kwemaurotransmitters, protein synthesis, nezvimwe.
Mukuwedzera, iyewo ari neuromodulator, N-Methyl-DL-Aspartic Acid ine simba rekugadzirisa muhutano hwemagetsi, uye inobatanidzwa muhutano hwemagetsi ekufambisa uye neuroprotection.
N-Methyl-DL-Aspartic Acid, komisheni inowanzoitika muuropi hwemunhu, inoita basa rakakosha mu synaptic plasticity, chiitiko chakakosha mukudzidza nekuumbwa kwendangariro. Synaptic plasticity inoreva kugona kweuropi kusimba kana kupera simba nekufamba kwenguva, zvichienderana nekusimba uye kuwanda kwekuita kweneural. NMDAA inobata zvakanangaN-Methyl-DL-Aspartic (NMDA) receptors, iyo inobatanidzwa mukukwanisa kwenguva refu (LTP) - kusimbiswa kwekubatanidza synaptic.
Imwe yenzira huru iyo N-Methyl-DL-Aspartic Acid inogona kuvandudza ndangariro ndeyekufambisa kutaurirana pakati pemasero ehuropi. NMDA inoita senge neurotransmitter inosunga kune chaiwo mareceptor muuropi, kunyanya muhippocampus, iyo ine basa rekugadzira ndangariro nyowani. Nekusunga kune aya ma receptors, NMDA inobatsira kusimbisa hukama pakati peeuroni, zvichiita kuti zvive nyore kuti ruzivo rugadziriswe nekuchengetwa zvakanaka.
Uyezve, zvidzidzo zvakaratidza kuti N-Methyl-DL-Aspartic Acid inokurudzira kusunungurwa kweuropi-derived neurotrophic factor (BDNF), puroteni yakakosha pakukura uye kurarama kwemasero matsva muuropi. BDNF inoita basa rakakosha muuropaplasticity, kugona kwehuropi kuumba patsva nekuronga patsva maneural connections mukupindura kudzidza nezviitiko. Nekuwedzera kuwanikwa kweBDNF, NMDA inotsigira kusikwa kwenzira itsva dzeneural, kusimbisa zvese zviri zviviri ndangariro uye kugona kudzidza.
Ehe, mabhenefiti eN-Methyl-DL-Aspartic Acid haana kuganhurirwa kundangariro uye kugona kudzidza. Zvimwe zvidzidzo zvinoratidza kuti zvinogonawo kuvandudza kushanda kwekuziva kwese. NMDAAs dzakaratidzwa kuti dzinokanganisa mamwe maitiro eurotransmitter, akadai se dopaminergic uye serotonergic nzira, iyo inobatanidzwa mukugadzirisa mafungiro, kutarisa, uye kukurudzira. Nekugadzirisa masisitimu aya, N-Methyl-DL-Aspartic Acid inogona kubatsira kuvandudza kutarisa, kusvinura, uye kujeka kwekufunga, zvichiwedzera kuwedzera kugona kwekuziva.
Pakazara, N-Methyl-DL-Aspartic Acid inoratidza kugona kukuru kwekuvandudza ndangariro nekudzidza. Inonatsiridza mabasa ekuziva anodiwa pakubudirira kwedzidzo uye nehunyanzvi nekukanganisa synaptic plasticity uye neuroprotective michina. Pamusoro pezvo, mhedzisiro yayo pane mamwe ma neurotransmitter masisitimu anogona kubatsira kuvandudza kwese kwekuziva kuita. Nepo kumwe kutsvagisa kuchiri kudikanwa, NMDAA yekuwedzera inopa nzira inonakidza kune avo vari kutsvaga kusimudzira kugona kwavo kwekuziva uye kuchengetedza pfungwa dzavo dzakasvinura muhupenyu hwese.
N-Methyl-DL-Aspartic Acid inoitika zvakasikwa amino acid inoita basa rakakosha mune akasiyana maitiro emuviri mumuviri. Inonyanya kuwanikwa muzvokudya zvine mapuroteni zvakadai senyama, hove, mazai, uye zvigadzirwa zvemukaka. Zvisinei, inowanikwawo kuburikidza nekuwedzera. Tevere, ngationgororei kufanana uye mutsauko pakati pekuwana N-Methyl-DL-Aspartic Acid kubva kune zvekudya uye kuitora sewedzero!
Chekutanga, kuti uwane N-Methyl-DL-Aspartic Acid zvakananga kubva kuchikafu, chikafu chine mapuroteni ane huwandu hwakasiyana hweiyi amino acid. Vanhu vanokwanisa kuzadzisa zvido zvavo zveNMDAA nekudya kudya kwakaringana kunosanganisira mapuroteni. Uyezve, kuwana N-Methyl-DL-Aspartic Acid kubva mukudya kwese kune bhenefiti yakawedzerwa yekuve nezvimwe zvakakosha zvinovaka muviri zvaunoda kune hutano hwese.
Kune rimwe divi, chikafu chega chinogona kusagara chakakwana kusangana neN-Methyl-DL-Aspartic Acid zvinodiwa zvevamwe vanhu. Vamhanyi, vanovaka muviri, kana avo vari kudzidziswa zvakanyanya mumuviri vangada madosi epamusoro eNMDAAs kutsigira kupora kwemhasuru uye kukura. Muchiitiko ichi, N-Methyl-DL-Aspartic Acid yekuwedzera inogona kutariswa.
N-Methyl-DL-Aspartic Acid supplements inouya nenzira dzakawanda, kusanganisira poda nemacapsules, uye inowanikwa zviri nyore. Iwo anowanzo ane yakacheneswa kana yekugadzira NMDAA, zvichiita kuti zvive nyore kudzora uye kuyera kudya. Pamusoro pezvo, zvekuwedzera zvinopa nzira iri nyore yekuve nechokwadi chekupihwa kwakaringana kweN-Methyl-DL-Aspartic Acid, kunyanya kune avo vane zvirambidzo zvekudya, allergies, kana kuomerwa nekudya zvakaringana-mapuroteni chikafu.
Zvisinei, zvakakosha kuziva kuti N-Methyl-DL-Aspartic Acid supplements inofanira kushandiswa nekuchenjerera. Usati waisa chero chitsva chekuwedzera mumaitiro ako, zvinokurudzirwa kubvunza nyanzvi yezvehutano kana akanyoreswa dietitian. Ivo vanogona kuongorora zvaunoda chaizvo uye kuona iyo yakakodzera dosi yeN-Methyl-DL-Aspartic Acid yemamiriro ako chaiwo.
Nepo ma supplements anogona kupa anonangwa uye ari nyore edzero, haafanire kutsiva chikafu chakatenderedzwa. Zvokudya zvakakwana zvinopa kwete N-Methyl-DL-Aspartic Acid chete, asiwo zvakasiyana-siyana zvekuwedzera hutano uye hutano hunobatsira. Kuchengeta kudya kwakaringana uye kwakasiyana-siyana kwakakosha kuti uve nechokwadi chehutano hwakanyanya uye kugara zvakanaka.
Kupfupisa, tinogona kuwana N-Methyl-DL-Aspartic Acid kubva kune zvekudya masosi kana kuburikidza nekuwedzera. Nepo kudya kwakaringana kuchifanira kunge kuri kwekutanga sosi yeNMDAA, zvekuwedzera zvinogona kupa mhinduro iri nyore kune vanhu vane zvavanoda kana zvirambidzo zvekudya. Nekudaro, zvakakosha kuti utsvage zano rehunyanzvi usati waisa chero chitsva chekuwedzera muhurongwa hwako. Pakupedzisira, musanganiswa wekudya kwakanaka uye kwakanangwa yekuwedzera (kana zvichidikanwa) inogona kubatsira kuve nechokwadi chepamusoro mazinga eN-Methyl-DL-Aspartic Acid yehutano hwakakwana.
Tisati tashandisa NMA, tinofanira kunzwisisa kuchengeteka uye migumisiro yeNMA, kuitira kuti tigone kushandisa zviri nani simba guru reNMA pasina kukuvadza muviri.
Panyaya yekuchengeteka kutanga, zvakakosha kuti uzive kuti NMA inowanzoonekwa yakachengeteka kana ichitorwa mumitengo yakakodzera. Nekudaro, senge chero imwe komputa, kuwandisa kweNMDA kunogona kukonzera mhedzisiro. Zvakakosha kutevedzera zvinokurudzirwa uye kubvunza nyanzvi yezvehutano usati watanga chero chekuwedzera.
Imwe yeanogona mhedzisiro yeNMAs ndeye excitotoxicity. Excitotoxicity inoitika kana NMA receptors yakawandisa, zvichitungamira kune calcium ion kuwandisa uye kunotevera kukuvadza kune neuroni. Ichi chiitiko chakabatanidzwa kune akati wandei neurodegenerative zvirwere, senge Alzheimer's uye Parkinson's. Nekudaro, zvakakosha kucherechedza kuti excitotoxicity inonyanya kubatanidzwa neakakwira madosi eNMA, ayo asingawanzo kuwanikwa mune zvekudya masosi kana chiyero chekuwedzera.
Imwe mhedzisiro yeNMA ndiyo inogona kuitika pane hormonal balance. Imwe tsvagiridzo inoratidza kuti kuwandisa kweNMA kutora kunogona kukanganisa kugadzirwa uye kudzora kwemamwe mahomoni, akadai se testosterone. Uku kusaenzana kwemahomoni kunogona kuve nemhedzisiro yakaipa pahutano hwekubereka uye hutano hwese. Nekudaro, kutsvagisa kwakawanda kunodiwa kuti unzwisise nzira chaiyo uye yenguva refu mhedzisiro yeNMA pamazinga ehomoni.
Pamusoro pezvo, vanhu vane pre-exist medical conditions vanofanira kungwarira kana vachifunga nezveNMA supplementation. Semuenzaniso, vanhu vane pfari kana nhoroondo yepfari vanofanira kudzivisa kuwedzera kweNMA, sezvo inogona kukonzera kubatwa nemigumisiro yeNMA receptors.
Nekuda Kushandiswa Kuri Kufungwa Nepo ichiwanzoonekwa seyakachengetedzeka kana ichidyiwa mumadhora akakodzera, kunwa zvakanyanya kunogona kukonzera mhedzisiro yakaipa senge excitotoxicity uye kusaenzana kwehomoni. Vanhu vane zvirwere zvakagara zviripo (kunyanya pfari uye nhoroondo yepfari) vanofanira kungwarira pavanofunga nezvekuwedzera kweNMA. Sezvakaita chero chekuwedzera, zvakakosha kubvunza nyanzvi yezvehutano usati waisa maNMA muchirongwa chekurapa chega.
Mubvunzo: Zvinotora nguva yakareba seiN-Methyl-DL-Aspartickushanda?
A: Migumisiro yeN-Methyl-DL-Aspartic acid inogona kusiyana zvichienderana nemunhu, dosage, uye nzira yekutonga. Nekudaro, kazhinji, zvinotendwa kuti N-Methyl-DL-Aspartic acid inogona kutora chero kubva maminetsi mashoma kusvika maawa mashoma kutanga kushanda. Zvinokurudzirwa kuonana nenyanzvi yezvehutano kana kutevedzera mirairo yakapihwa nemugadziri kuti uwane rumwe ruzivo rwekuti zvinotora nguva yakareba sei kuti komboni iyi itange kushanda.
Disclaimer: Ichi chinyorwa ndechezvinangwa zveruzivo chete uye hachifanirwe kutorwa sezano rekurapa. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kushandura hutano hwehutano hwako.
Nguva yekutumira: Jul-07-2023
