Mukutsvaga kwedu kwehutano huri nani uye kugara zvakanaka kwese, tinowanzosangana neakasiyana makomisheni uye mamorekuru anoita basa rakakosha mukuwedzera kugona kwemiviri yedu. Adenosine, nucleoside inongoitika, nderimwe remorekuru riri kugamuchira kuwedzera kutarisisa kune zvakakosha zvehutano. Kubva pakusimudzira hutano hwemoyo kusvika pakupa simba nekutsigira metabolism, adenosine ine mukana mukuru wekusimbisa miviri yedu kubva mukati kunze.
Adenosine chinhu chinongoitika chinowanikwa musero rese mumuviri wedu. Iyo molekuru yakakosha inobatanidzwa mune zvakasiyana-siyana zvemuviri maitiro, kusanganisira simba rekufambisa uye kuyerera kweropa.
Adenosine, nucleoside, inoumbwa neshuga molecule (ribose) uye adenine, imwe yemabhesi mana anowanikwa muDNA neRNA. Inoita basa rakakosha mukugadzirwa kweadenosine triphosphate (ATP), mari yesimba remasero edu. Kana miviri yedu ichida simba, ATP inoputsika kuita adenosine diphosphate (ADP) uye mahara phosphate mapoka, kuburitsa simba rekugonesa akasiyana metabolic mabasa.
Pamusoro pebasa rayo musimba metabolism, adenosine inobatanidzwawo mukusaina maitiro mumiviri yedu. Inoshanda seyeurotransmitter, kemikari messenger inotakura zviratidzo pakati pemasero etsinga. Adenosine ine simba rekusunga kune chaiwo receptors muuropi, zvichikonzera zvakasiyana-siyana zvinokonzerwa neural chiitiko uye kukanganisa kurara, kumutsa, uye kumutsa.
Mundima yezvekurapa, adenosine inowanzoshandiswa semushonga panguva yekuongororwa kwemoyo. Inopihwa mutsinga kuti iwedzere kuyerera kweropa kumwoyo kwenguva pfupi uye kukonzera kumanikidzwa, zvichibvumira vashandi vehutano kuti vaongorore kushanda kwemoyo. Adenosine ine hafu yehupenyu hupfupi uye mhedzisiro yayo inokurumidza kudzoserwa, zvichiita kuti ive yakachengeteka uye inoshanda chishandiso mumaitiro akadaro ekuongorora.
Kubva pamatanho ekufambisa simba anoyananiswa nemamorekuru akadai seAMP, ADP neATP, kuenda kuchikamu chekutonga chinoitwa necAMP mukusaina sero, adenosine inoramba iri chinhu chakaoma kunzwisisa uye chakakosha chemichina yakaoma yehupenyu.
●Adenosine monophosphate (AMP): AMP inokosha metabolite inobatanidzwa mu intracellular energy transfer. Nekubata simba rinoburitswa panguva dzemaserura maitiro, AMPs dzinotamba zvakakosha munucleotide biosynthesis, protein phosphorylation, uye chiratidzo chekufambisa. Uye zvakare, iri precursor molecule ye synthesis yeadenosine triphosphate (ATP), iyo huru simba remari yezvipenyu.
●Adenosine diphosphate (ADP): Senhengo inotevera yemhuri yeadenosine, adenosine diphosphate (ADP) inoita basa rinokosha mumasero emagetsi metabolism. ATP inogadzirwa nehydrolyzed kuumba ADP, ichiburitsa phosphate mapoka uye simba rinodiwa kune akasiyana maitiro emuviri. ADP inoshanda seyakatangira yeAMP synthesis uye inogona kuzadza intracellular ATP mazinga. Iyi kutenderera kweATP hydrolysis kune ADP uye kunotevera kuvandudzwa kunovimbisa kuenderera kuripo kwesimba rinodiwa kune cellular basa.
●Adenosine triphosphate (ATP): Pasina mubvunzo, adenosine triphosphate (ATP) ndiyo inonyanya kuzivikanwa uye inonyanya kukosha yeadenosine. ATP inoshanda semari yesimba repasi rose muzvisikwa zvese zvipenyu, ichishanda sedura resimba rinopisa maitiro mazhinji ehupenyu. Kungave kudhonzwa kwemhasuru, kufambiswa kwetsinga, kana kufambisa kunoshanda kuyambuka maseru membranes, ATP inokurumidza kupa simba pese uye pese parinodiwa. Nekukurumidza kuendesa iyo terminal phosphate boka kune chaiyo chinangwa, ATP inopa simba rinodiwa kune cellular zviitiko ichizoshandurwa kuita ADP.
●Adenosine deaminase (ADA) - ADA inobatanidzwa mu purine metabolism, inodiwa kuti nucleic acid ishanduke mumatishu, uye inotsigira kukura nekuchengetedzwa kwemasimba ekudzivirira zvirwere nekushandura chepfu deoxyadenosine kuva lymphocytes.
●Cyclic adenosine monophosphate (cAMP): Pamusoro pesimba metabolism, tinosanganawo necyclic adenosine monophosphate (cAMP). Iyi molecule diki asi ine simba inhume mukusaina nzira, ichiita semutumwa wechipiri kune akasiyana mahormone uye neurotransmitters. cAMP inoita mhedzisiro yayo nekuita maprotein kinases, ayo anodzora akawanda cellular maitiro senge gene kutaura, kupararira kwesero, uye synaptic plasticity. Nekugadzirisa zviitiko zvakakosha izvi, cAMP inobatsira kuchengetedza cellular homeostasis uye kuronga mhinduro dzakasiyana dzemuviri.
1. Kuvandudza hutano hwemwoyo
Adenosine yakawanikwa iine mabhenefiti akawanda kune yedu yemwoyo system. Chekutanga, adenosine inozorodza vascular yakatsetseka tsandanyama nekudzikisa kunyura kwecalcium uye activate adenylate cyclase mumasero akatsetseka emhasuru. Iine simba vasodilator, zvinoreva kuti inoderedza tsinga dzedu dzeropa, nokudaro ichiwedzera mvura yemuviri. kubuda kweropa. Nekuve nechokwadi chekupa ropa rakakwana kumoyo nedzimwe nhengo, adenosine inoderedza njodzi yezvirwere zvemoyo senge chirwere chemoyo uye sitiroko.
Pamusoro pezvo, adenosine ine cardioprotective mhedzisiro, inodzivirira kukuvadzwa kwemoyo tishu panguva yekuderera kwekuyerera kweropa. Inopa dziviriro yakakosha panguva yekurwiswa kwemoyo, inoderedza kukuvadzwa kwemhasuru yemoyo, uye inogona kubatsira mukugadzirisa mushure mekurwadziwa kwemoyo.
2. Ipa simba uye kutsigira metabolism
Adenosine imorekuru inoita basa rakakosha mumetabolism. Iyo nucleoside inoumbwa neadenine uye ribose uye inobatanidzwa mune akasiyana metabolic maitiro mumuviri.
ATP ndiyo molecule huru inotarisira kuchengetedza simba uye kutakura mumaseru. Adenosine inobatanidzwa mukugadzirwa kweadenosine triphosphate (ATP) uye chinhu chakakosha cheATP. Kuburikidza nekutevedzana kwemaitiro ebiochemical, inogona kushandurwa kuita ATP kuti ipe simba remaserura maitiro.
Mukuwedzera, adenosine inobatanidzwawo mukugadzirisa kwemasabolism kuburikidza nekubatana nema receptors mumasero. Adenosine receptors inowanikwa mune akasiyana matishu uye nhengo, uye kana adenosine ichisunga kune aya ma receptors, inogadzirisa metabolic maitiro mumuviri.
Adenosine yakaratidzwa kuti inodzivisa kuparara kweglycogen, fomu yekuchengetedza glucose mumuviri. Nekudzivisa kuparara kweglycogen, adenosine inobatsira kuchengetedza glucose homeostasis uye inovimbisa kugadzikana kwesimba kune muviri.
3. Kuvandudza kurara
Adenosine inoita basa rakakosha mukufambiswa neurotransmission muuropi hwedu, kunyanya mukudzora kutenderera kwekurara-kumuka. Inoita sechisikigo sedative mukati mepakati tsinga system, inosimudzira kurara uye kubatsira kudzora maitiro edu ekurara. Adenosine mazinga muuropi zvishoma nezvishoma anowedzera zuva rose, achikurudzira manzwiro ekuneta uye kurara. Nekusunga kune chaiwo mareceptor muuropi, adenosine inobatsira kukwezva uye kuchengetedza hope dzakadzika. Naizvozvo, mazinga akakwana eadenosine akakosha pahutano hwakanaka hwekurara uye kuzorora kwese.
Uyezve, adenosine inobatanidzwa mukugadzirisa ndangariro uye kuyeuka. Yakaratidzwa kuwedzera kudzidza uye kubatanidzwa kwendangariro, zvichiita kuti ive mukana wekurapa wakanangwa kune vanhu vane mamiriro akadai sechirwere cheAlzheimer kana mamwe matambudziko ekuziva.
4. Kuvandudza kurovedza muviri uye kupora kwemhasuru
Adenosine yakawanikwa iine maitiro akasiyana-siyana pamitambo yemitambo, iyo inogona kubatsira zvikuru kune vatambi kana vanhu vanotarisa kuwedzera kugona kwavo kwemuviri. Nokuwedzera kuyerera kweropa, adenosine inovimbisa kuti mhasuru dzinogamuchira okisijeni yakakwana uye zvinovaka muviri panguva yekurovedza muviri, nokudaro zvichiwedzera kutsungirira uye kunonoka kuneta.
Mukuwedzera, adenosine inokurudzira kusunungurwa kwe nitric oxide, vasodilator iyo inowedzera kuwedzera kuyerera kweropa uye kuendeswa kweokisijeni kumisungo. Izvi zvinowedzera oxygenation inobatsira kukurumidza kupora tsandanyama uye inoderedza njodzi yekukuvara-kunokonzerwa nekukuvara.
Kunyange zvazvo adenosine inowanzoitika mumitumbi yedu, tinogona kuwedzera kuwedzera mazinga nekudya zvokudya zvine zvimwe zvinovaka muviri kana izvo zvinotangira.Ngationgorore zvimwe zvezvokudya zvakanakisisa zvingasanganisira muzvokudya zvedu kuti tiwedzere mazinga eadenosine zvakasikwa.
●Nyama uye Huku: Yakaonda nyama yemombe, huku uye turkey. Nyama idzi dzinopawo zvakakosha amino acids, uye kuwedzera nyama yakaonda nehuku pakudya kwako kunogona kubatsira kutsigira kugadzirwa kweadenosine.
●Mbeu nenyemba: Mbeu dzakaita senyemba, pizi, nebhinzi dzeitsvo dzinosimudzirawo kugadzirwa kweATP uye inzvimbo yakanaka kwazvo yemapuroteni ezvirimwa. Kugara uchiwedzera ma legumes pakudya kunogona kupa zvinovaka muviri asi zvichingowedzera adenosine mazinga.
●Zvokudya zvegungwa: Hove dzakadai sesaumoni, sardines, trout, mackerel uye cod ndizvo zvakanaka zvinokanganisa mazinga adenosine. Uyezve, chikafu chegungwa chinopa omega-3 fatty acids, iyo ine zvakawanda zvehutano zvinobatsira, zvichiita kuti zvive zvakakosha kuwedzera kune menyu yako.
●Mbeu dzakakwana: Kusanganisira zviyo zvakakwana se oats, mupunga webrown, uye quinoa mukudya kwako kwete kungopa fiber yakakosha uye kudya, asiwo kubatsira mukugadzirwa kweadenosine. Mbeu idzi dzine adenosine monophosphate (AMP), inotangira adenosine inoshandurwa mumiviri yedu kuti ive nechokwadi chekupihwa kwakasimba kweiyo nucleotide yakakosha.
●Green tii: Green tii inopfuma sosi yeadenosine analogi inonzi katechin. Kunyange zvazvo zvingave zvisingapi zvakananga adenosine, makatechini ane chimiro chakafanana chinovabvumira kusunga uye kumisa adenosine receptors mumitumbi yedu, kukurudzira kuzorora uye hutano hwose.
Kudya kwakadzikama kwakakosha kuchengetedza huwandu hwesimba nekuti macronutrient imwe neimwe ine mhedzisiro yakasiyana paATP.
ATPmazinga anogona kupihwa kuburikidza nekudya kwakaringana nekuti muviri unoshandisa mamorekuru muchikafu kugadzira ATP uye simba, asi kune vamwe vanhu vanodya monotonous kudya, ATP yekuwedzera isarudzo yakanaka.
Kuti tinyatsonzwisisa mabhenefiti eadenosine uye ATP anowedzera, zvakakosha kuti tinzwisise basa ravo mukugadzirwa kwesimba remuviri wedu. Adenosine triphosphate (ATP) inowanzonzi "mari yesimba" yesero. Iyo ine basa rekupa simba kune yese sero mumuviri wedu uye kuita mabasa akakosha senge tsandanyama contraction, nerve chiitiko uye metabolism. Adenosine, kune rumwe rutivi, inokosha neurotransmitter inodzora kurara uye kumuka.
Adenosine 5'-triphosphate disodium munyu is nucleotide inoshandiswa sesosi yesimba remagetsi. Inoumbwa neadenosine uye matatu phosphate mapoka, ndiyo inonyanya kukosha mamorekuru mune metabolism. Komisheni iyi inoita basa rakakosha mukudzokorodza simba remagetsi uye inosanganisirwa mune dzakasiyana siyana biochemical uye physiological maitiro, senge tsandanyama contraction uye nerve impulse transmission. Sekuwedzera kweATP, inogona kupa simba metabolism kumuviri wemunhu uye kushanda se coenzyme mukati memasero.
Paunenge uchifunga nezve adenosine uye ATP yekuwedzera, zvakakosha kusarudza zvigadzirwa zvemhando yepamusoro kubva kune zvinozivikanwa zvinyorwa. Tarisa ma supplements anogadzirwa pasi peakasimba emhando yekudzora matanho uye kunyatsoongororwa kuchena uye kushanda. Funga kubvunzana nenyanzvi yezvehutano kana nyanzvi yezvekudya kuti uone yakakodzera yekuwedzera dosi uye nguva zvichienderana nezvaunoda iwe pachako.
Mubvunzo: Adenosine inobata sei hutano hwemwoyo?
A: Adenosine inoita basa rakakosha mukudzora hutano hwemoyo. Inoshanda sechisikigo vasodilator, zvichireva kuti inobatsira kuwedzera tsinga dzeropa, kunatsiridza kuyerera kweropa uye kuderedza BP. Nekudzikisa tsinga dzeropa, adenosine inobvumira okisijeni yakawanda uye chikafu kusvika kumoyo uye dzimwe nhengo. Izvi zvinobatsira mukuchengetedza hutano hwemoyo wese.
Mubvunzo: Ndeapi masosi eadenosine mumuviri?
A: Adenosine inowanzoitika mumuviri uye inogona kuwanikwa munzvimbo dzakasiyana siyana. Inotorwa kubva kuadenosine triphosphate (ATP), molecule inotarisira kuchengetedza uye kuendesa simba mukati memasero. ATP inoputsika kuita adenosine diphosphate (ADP) uye yobva yaputsika kuita adenosine monophosphate (AMP). Pakupedzisira, AMP inoshandurwa kuita adenosine. Kunze kweizvi, adenosine inogonawo kuwanikwa kubva kune zvekudya zvakaita sezvimwe zvekudya uye zvinwiwa.
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Nguva yekutumira: Oct-20-2023
