Muminda yebiochemistry nemishonga, Spermine (polyamine), seyakakosha biomolecule, yakagamuchira kutariswa kwakapararira nekuda kwebasa rayo rinokosha mukukura kwesero, kupararira uye maitiro akasiyana-siyana ehupenyu. Sezvo tsvakiridzo yehutano, kuchembera uye cellular basa richienderera mberi, kudiwa kweSpermine kunoramba kuchiwedzera. Nekudaro, kune vakawanda vanogadzira Spermine pamusika, uye nzira yekuwana yakavimbika Spermine mugadziri rave basa rakakosha kune vanotsvaga uye mabhizinesi. Paunenge uchitsvaga akavimbika Spermine mugadziri, zvakakosha kuti usarudze ane mukurumbira mutengesi.Suzhou Mylandyave sarudzo yekutanga yevazhinji vaongorori vesainzi uye mabhizinesi ane ayo akakwirira-kuchena zvigadzirwa, nyanzvi yehunyanzvi rutsigiro nemitengo yemakwikwi. Kunyangwe iwe uri kuita tsvakiridzo yekutanga kana kusimudzira kwekushandisa, Suzhou Mailun Biotechnology inogona kukupa yemhando yepamusoro Spermine kuti ikubatsire mukutsvaga kwako kwesainzi uye rwendo rwekuvandudza. Paunosarudza Suzhou Myland, hauzongowani zvigadzirwa chete, asiwo mudiwa akavimbika.
Spermine inorongedzerwa se polyamine, boka remakomisheni akaumbwa anoratidzwa nekuvapo kweakawanda mapoka emamine. Polyamines, kusanganisira putrescine, spermidine, uye spermine, zvakakosha pakukura kwesero uye kushanda. Ivo vanobatanidzwa mumhando dzakasiyana dzezvipenyu zvakaita sekuwedzera kwesero, kusiyanisa, uye apoptosis. Kunyanya, spermine chigadzirwa che enzymatic shanduko ye spermidine, imwe polyamine.
Spermine inonzi polyamine ine mapoka maviri emamino uye mapoka maviri emamino, ane basa rinokosha rekusimudzira kupararira kwemasero. Spermine, semusanganiswa we organic unobata basa rakakosha muzvisikwa zvipenyu, tsananguro yayo uye maitiro inyaya yakakosha mundima yebiology uye chemistry.
Ichi chinhu hachingori chakasiyana muchimiro, chine akawanda amino nemapoka emino, asi zvakare inotamba yakakosha basa remuviri mune zvipenyu. Spermine is a colorless crystalline solid.
Inonyungudika zviri nyore mumvura pane yakajairika tembiricha, uye kana yabatanidzwa, inoumba mhinduro ine alkaline maitiro. Kemikari, spermine inoburitsa muchetura nitrogen oxide kana yapiswa, izvo zvinoda kutariswa kwakanyanya pakubata nekuchengetedza urume.
Mu vivo, nzira yekubatanidza yespermine inosanganisira yakaoma enzymatic kutendeuka muitiro pakati pe putrescine (yakareruka diamine compound) uye S-adenosylmethionine. Iyi nzira inosanganisira yakaoma biochemical reactions, inoratidza kusiyana uye kukosha kwema enzymes muzvisikwa.
Spermine uye spermidine inowanikwa pamwe chete mubhakitiriya uye masero mazhinji emhuka, uye ese ari maviri akakosha zvinhu mukuwedzera kwesero. Rimwe remabasa makuru ehupenyu hwespermine kusimudzira kuwanda kwesero. Spermine inobata basa rakakosha mukuita kwekuparadzaniswa kwesero uye kukura, kunyanya mukugadzikana kweDNA uye protein synthesis.
Inogona zvakare kuratidza polycationic zvimiro pasi pe acidic mamiriro, ayo anobvumira spermine kusunga kuDNA, RNA uye mamwe mamorekuru, nekudaro kukanganisa basa uye chimiro chemasero.
Kubva pamaitiro ekuona, spermine inogona kutorwa seimwezve inobuda kubva kune amino acid inobuda. Yayo yakaoma tetraamine-yakavakirwa chimiro inopa iyo yakasarudzika biological chiitiko uye physiological regulatory mabasa.
Muchikamu chebiochemical, spermine, putrescine, spermidine, nezvimwewo pamwe chete zvinoumba mhuri yemapoliamine anowanikwa zvakanyanya muzvisikwa. Aya mamorekuru anoita basa mukugadzirisa gene expression, kudzora kutenderera kwesero, uye kutora chikamu munzira dzakasiyana siyana dzekusaina sero. basa rinokosha.
Naizvozvo, spermine haingori nyore organic molecule, asiwo yakakosha chikamu mune yakanaka kudzora maitiro ehupenyu. Tsvagiridzo yaro inosanganisira akatiwandei akasiyana siyana senge molecular biology, genetics, uye pharmacology.
Chii chinonzi autophagy?
Autophagy inzira yakakosha mukati memasero anochengetedza zvakajairika maseru mabasa nekudzikisira uye kudzoreredza akakuvadzwa mapuroteni uye organelles. Autophagy inogona kubvisa zvinhu zvinokuvadza kubva kumaseru, kubatsira maseru kurarama mumatambudziko, kukurudzira hutano hwesero uye kuwedzera hupenyu.
Basa re autophagy mukurwisa kukwegura
Bvisa marara emasero: Patinokura, huwandu hukuru hwemapuroteni akakuvadzwa uye organelles anounganidza mumasero. Izvi zvinhu zvinokuvadza zvinogona kukanganisa kushanda kwesero uye kutungamirira kukwegura uye zvirwere. Autophagy inogona kukanganisa marara aya, kuchengetedza hutano hwemasero, uye kunonoka kuchembera.
Chengetedza hutano hwemitochondrial: Mitochondria ndiwo mafekitori emagetsi emasero, uye kudzikira kwebasa ravo ndechimwe chezvikonzero zvakakosha zvekukwegura. Autophagy inononoka kuchembera kwemasero nekusarudza kubvisa mitochondria yakakuvadzwa, kuchengetedza mitochondrial basa, uye kuderedza kugadzirwa kweanokuvadza reactive oxygen marudzi (ROS).
Kurudzira kupona kwesero: Autophagy inogona kupa rutsigiro rwesimba kubatsira maseru kurarama kana chikafu chishoma. Uye zvakare, autophagy inosimudzirawo kuzvivandudza kwe stem maseru uye kuvandudzwa kwetishu, kuchengetedza hudiki hwemuviri.
Spermine: a natural inducer ye autophagy
Spermine musanganiswa we polyamine unowanikwa muzvisikwa zvese zvipenyu izvo zvinokurudzira autophagy. Zvidzidzo zvakawana kuti exogenous spermine supplementation inogona kuwedzera hupenyu mumhando dzakasiyana siyana, kusanganisira mbiriso, nematodes, nhunzi dzemichero, uye mbeva.
Kurudzira autophagy: Spermine induces autophagy nekudzivisa acetyltransferase (yakadai seEP300), nokudaro kubvisa zvinhu zvinokuvadza mumasero uye kudzivirira zvirwere zvine chokuita nekukwegura.
Anti-inflammatory uye antioxidant: Spermine ine anti-inflammatory uye antioxidant properties, inowedzera kushandiswa kwemasabolism e mitochondria, inosimudzira mapuroteni homeostasis, uye inodzivirira hutano hwemaserura.
Kuvandudza immune system: Spermine inogona kukurudzira kuumbwa kwendangariro T masero, kudzivirira kuchembera kwe immune system, uye kuwedzera kudzivirira kwechirwere chemuviri.
tsvakurudzo zvakawanikwa
Kuwedzerwa hupenyu: Exogenous spermine supplementation inogona kuwedzera zvakanyanya hupenyu hwemhando dzakasiyana dzezvipenyu. Semuenzaniso, kudyisa mbeva spermine yakawedzera hupenyu hwavo uye yakaratidza moyo uye neuroprotective mhedzisiro.
Anticancer uye kudzivirira kwemoyo: Spermine inowedzera anticancer immune surveillance uye cardioprotective mhedzisiro nekuita autophagy. Mune makonzo, izvi zvinokanganisa zvinorasika kana autophagy ikavharwa.
Inoderedza kuzvimba uye inovandudza kusadzivirirwa: Tsvagiridzo inoratidza kuti spermine inogona kuderedza mhinduro dzekuzvimba uye kugadzirisa immune system basa nekukurudzira kuumbwa kwendangariro T masero.
Seyakakosha nzira yekudzivirira yemasero, autophagy inoita basa rakakosha mukurwisa kukwegura. Spermine, sechisikigo inducer ye autophagy, ine mhedzisiro yakakosha pakunonoka kuchembera nekudzivirira zvirwere zvine hukama nekusimudzira autophagy, anti-inflammatory uye antioxidant nzira. Kuwedzera spermine kudya kuburikidza nekudya kana kuwedzera kunogona kuve nzira inoshanda yekusimudzira hutano kuchembera.
1. Sero Utano uye Kukura
Imwe yemabhenefiti makuru espermine ibasa rayo mukusimudzira hutano hwesero uye kukura. Spermine yakakosha pakuwedzera kwesero uye kusiyanisa uye yakakosha pakugadzirisa matishu uye kuvandudzwa. Iyo inodzikamisa chimiro cheDNA neRNA uye inovimbisa yakajairika cellular basa. Izvi zvinonyanya kukosha mumamiriro ekupora maronda uye kupora kwekukuvara, uko kukurumidza kupatsanurwa kwesero kunodiwa.
Uyezve, spermine yakaratidzwa kuchengetedza masero kubva kune oxidative kusagadzikana, izvo zvinogona kutungamirira mukukuvadzwa kwesero uye kukwegura. Nekubvisa mahara radicals, spermine inobatsira kuchengetedza kuvimbika kwesero uye kushanda, zvichibatsira kuhutano hwese uye hupenyu hurefu.
2. Anti-kuchembera zvinhu
Sezvatinokura, miviri yedu inochinja zvakasiyana-siyana, kusanganisira kuderera kwema polyamines akadai sespermine. Tsvagiridzo inoratidza kuti spermine inogona kunge iine anti-kuchembera zvivakwa, zvichiita kuti ive yakakosha kuwedzera kune kuchengetedza ganda uye hutano zvigadzirwa. Kugona kwayo kukurudzira kukura kwesero uye kugadzirisa kunogona kubatsira kurwisa zviratidzo zvinooneka zvekuchembera, semakwinya uye ganda rinodonha.
Pamusoro pezvo, spermine's antioxidant properties inoita basa rakakosha mukuderedza oxidative kusagadzikana, chinhu chakakosha mukuita kuchembera. Nekubatanidza spermine muhutano hwako hwekuchengetedza ganda, hausi kungovandudza chitarisiko cheganda rako, asiwo unotsigira hutano hwayo pamaserura.
3. Kutsigira kwekudzivirira kwemuviri
A yakasimba immune system yakakosha kune hutano hwese, uye spermine inogona kuita basa mukusimudzira immune system. Tsvagiridzo inoratidza kuti spermine inogona kuenzanisa maitiro ekudzivirira uye kubatsira muviri kudzivirira zvirinani kubva kuhutachiona uye chirwere. Yakaratidzwa kuti inokurudzira kugadzirwa kwemasero ekudzivirira muviri, akadai se lymphocytes, ayo anokosha mukurwisa zvirwere.
Pamusoro pezvo, spermine's anti-inflammatory properties inogona kubatsira kuderedza kuzvimba kusingaperi, izvo zvinosangana neakasiyana ehutano nyaya, kusanganisira autoimmune zvirwere uye zvisingaperi zvirwere. Nekutsigira hutano hwekudzivirira zvirwere, spermine inogona kubatsira kusimbisa kugona kwemuviri kurwisa zvirwere.
4. Neuroprotective effect
Uropi ndeimwe yenhengo dzakaomarara kwazvo mumuviri wemunhu, uye kuti huchengetedze hutano hwakakosha. Spermine yakawana kutarisisa kwayo neuroprotective mhedzisiro, iyo inogona kubatsira kudzivirira neurodegenerative zvirwere. Tsvagiridzo inoratidza kuti spermine inogona kudzivirira neurons kubva mukukuvadzwa kunokonzerwa neoxidative kusagadzikana uye kuzvimba, zvese zviri zviviri zvakabatana nezvirwere zvakaita seAlzheimer's uye Parkinson's disease.
Mukuwedzera, spermine inobata basa muurourotransmission, inokanganisa kusunungurwa kwemaurotransmitters, ayo anokosha pakukurukurirana pakati pemasero etsinga. Nekutsigira neuronal hutano uye basa, spermine inogona kubatsira kuvandudza cognitive kuita uye kuderedza njodzi yeurourodegenerative zvirwere.
Panyaya yekudzika kwemaindasitiri ekushandisa, spermine ine huwandu hwakawanda hwekushandisa. Chokutanga pane zvose, spermine inokosha yepakati mumunda wemishonga uye inoshandiswa zvakanyanya mumishonga inorwisa kenza uye mishonga yemwoyo. Kushanda kwayo kwakanaka, kuchengeteka uye kugadzikana kunofarirwa neindasitiri yemishonga.
Chechipiri, spermine ndeye yakajairika anionic surfactant ine yakanaka emulsification, kupinda uye decontamination kugona. Naizvozvo, inoshandiswa zvakanyanya muindasitiri yemakemikari, mishonga yezvipembenene, fiber, mineral processing, electroplating nemimwe minda, kunyanya muzvizoro, mushonga wemazino, shampoo uye zvimwe zvigadzirwa. inoita basa rinokosha mukugadzira.
Pamusoro pezvo, spermine inogona zvakare kushandiswa seyepakati kune organophosphorus mishonga yezvipembenene, ichiwedzera kuwedzera kushandiswa kwayo muindasitiri yemishonga yezvipembenene. Pakupedzisira, spermine, sechinhu chakakosha chinokurudzira kupararira kwemasero, inoshandiswawo mumunda wekurima. Inogona kuvandudza kunyura uye kushandiswa kwezvinovaka muviri nezvirimwa, uye kuwedzera goho nemhando.
Sezvo biotechnology, hutano hwekurapa, uye misika yekuchengeta munhu ichiramba ichikura, tarisiro yekushandiswa kwespermine sechinhu chakakosha kune tarisiro yakawanda. Kunyanya mumunda wemishonga, kugona kwayo mukurwisa-bundu zvinodhaka tsvakiridzo nekusimudzira, sero therapy uye genetic chirwere kurapwa kuri kukwezva huwandu hukuru hwesainzi tsvakiridzo yekudyara uye mabasa ekuvandudza, zvichiratidza kuti inogona kuve yakakosha kutyaira simba rekukura kwemaindasitiri mu. ramangwana.
Panguva imwecheteyo, spermine iri kuwedzera kushandiswa seyakanyorovesa uye inogadzirisa ganda muindasitiri yezvizorwa, ichiratidza kuwedzera kwevatengi kufarira kwechisikigo uye kwakanyanya kushanda kwezvigadzirwa zvekuchengetedza ganda, kutyaira kudiwa kwespermine mumusika wepamusoro-yekupedzisira runako chigadzirwa.
Uye zvakare, mumunda wekurima, kunyangwe kushomeka kwakadzikira mumisika yechinyakare senge acephate, kuongororwa kwespermine sechinhu chitsva chekusimudzira chirimwa chinosimudzira chinotarisirwa kuvhura nzira nyowani yekushandiswa kwegirinhi zvekurima uye kupindura kudiwa kwepasirese. kurima kwakasimba. mhinduro dzinodiwa nokukurumidza.
Kubva pamaonero ehunyanzvi hwekuvandudza tekinoroji, kuenderera mberi kwe spermine synthesis tekinoroji uye kudzora mutengo optimization kunovandudza kugadzirwa kwekugadzira uye kukwikwidza kwechigadzirwa, uye kuunza yakakura budiriro nzvimbo kuindasitiri. Yakabatanidzwa nerutsigiro-chikamu chegwaro uye nhungamiro yenguva dzose yebiotechnology uye kurima kwakasvibira, nharaunda yakanaka yekunze yakavakirwa kusimudzira kune hutano kweindasitiri yespermine.
Muminda yebiochemistry nemishonga, Spermine (polyamine), seyakakosha biomolecule, yakagamuchira kutariswa kwakapararira nekuda kwebasa rayo rinokosha mukukura kwesero, kupararira uye maitiro akasiyana-siyana ehupenyu. Sezvo tsvakiridzo yehutano, kuchembera uye cellular basa richienderera mberi, kudiwa kweSpermine kunoramba kuchiwedzera. Nekudaro, kune vakawanda vanogadzira Spermine pamusika, uye nzira yekuwana yakavimbika Spermine mugadziri rave basa rakakosha kune vanotsvaga uye mabhizinesi.
Pakati pevazhinji vagadziri veSpermine, Suzhou Myland inomira kunze kwayo yakanakisa chigadzirwa mhando uye masevhisi ehunyanzvi. Iyo Spermine yakapihwa naSuzhou Myland ine aNhamba yeCAS ye71-44-3 uye kuchena kweanopfuura 98%.Ichi chigadzirwa chepamusoro-chepamusoro hachingosangana nemazinga epasi rose, asi zvakare inoedzwa kwakasimba kwemhando kuti ive nechokwadi chekuti batch yega yega yezvigadzirwa inogona kusangana nezvinodiwa zvekutsvagisa kwesainzi uye maindasitiri ekushandisa.
1. Kuvimbiswa Kwehutano
Suzhou Myland inonyatsoziva kuti mhando yechigadzirwa ndiyo ibwe rekona rekupona kwebhizinesi nekusimudzira. Iyo kambani ine michina yekugadzira yepamusoro uye yakasimba yemhando yekutonga system kuti ive nechokwadi chekuti zvese zvigadzirwa zveSpermine zvinoedzwa zvakaomarara uye kuongororwa. Kungave kuri kutengwa kwezvinhu zvakabikwa kana chese chemaitiro ekugadzira, Suzhou Myland inoyedza kuwana hunyanzvi kuti ive nechokwadi chekuchena kwepamusoro uye yemhando yepamusoro yezvigadzirwa zvayo.
2. Professional technical support
Pamusoro pekupa yemhando yepamusoro Spermine, Suzhou Myland inopawo vatengi vane ruzivo rwehunyanzvi rutsigiro. Kungave kushandiswa kwechigadzirwa, mamiriro ekuchengetera, kana dhizaini yekuyedza, timu yekambani tekinoroji inogona kupa vatengi nhungamiro yakadzama uye mazano. Iyi sevhisi ine hanya haingogadziri kugutsikana kwevatengi chete, asiwo inowedzera kuvimba kwevatengi muchigadzirwa.
3. Mutengo wemakwikwi
Pachimiro chekuona mhando yechigadzirwa, Suzhou Myland yakazvipirawo kupa vatengi nemitengo yemakwikwi. Nekugadzirisa maitiro ekugadzira uye manejimendi ekutengesa, kambani inokwanisa kunyatso kudzikisa mitengo, nekudaro ichipfuudza mitengo inokwanisika kudzokera kune vatengi. Izvi zvinogonesa mamwe masangano ekutsvagisa kwesainzi uye mabhizinesi kuwana emhando yepamusoro Spermine nemitengo inonzwisisika uye inosimudzira kufambira mberi kwekutsvaga kwakabatana.
Kutenga sei
Kana iwe uchitsvaga yakavimbika Spermine mugadziri, Suzhou Myland hapana mubvunzo sarudzo yakavimbika. Iwe unogona kuwana rumwe ruzivo kuburikidza nekambani webhusaiti yepamutemo kana kubata timu yekutengesa zvakananga. Zvingave zvidiki-zvidiki zvekuedza zvinodiwa kana makuru-akawanda maindasitiri ekushandisa, Suzhou Myland inogona kupa mhinduro dzinochinjika zvinoenderana nezvinodiwa nevatengi.
Mubvunzo: Chii chinonzi spermine, uye inowanikwa kupi?
A: Spermine inowanzoitika polyamine komboni inowanikwa mumasero mapenyu ese. Iyo inonyanya kuvepo mune yakanyanya kuwanda mumatishu akadai seuropi, chiropa, uye prostate. Spermine inobatanidzwa mumhando dzakasiyana-siyana dzehupenyu, kusanganisira kukura kwemasero, kusiyanisa, uye kugadzikana kweDNA.
Q:Sei spermine inogona kuiswa mukudya kwangu?
A: Spermine inogona kuwanikwa mune zvakasiyana siyana zvekudya, kunyanya mu:
●Zvigadzirwa zvakaviriswa (sechizi nemuto wesoya)
●Dzimwe nyama (dzakadai sehuku nemombe)
●Hove
●Zviyo
●Legumes
Pamusoro pezvo, spermine supplements inowanikwa kune avo vari kutsvaga kuwedzera kudya kwavo.
Mubvunzo:Urume hunogona kubatsira hutano hweganda here?
A: Ehe, spermine inozivikanwa nekuda kwehutano hweganda. Inogona kubatsira kuvandudza elasticity yeganda, kuderedza kutaridzika kwemitsara yakanaka uye wrinkles, uye kukurudzira kwese kweganda hydration. Iyo antioxidant properties inobatsirawo kuchengetedza ganda kubva mukukuvadzwa kwezvakatipoteredza, zvichiita kuti rive chinhu chakakurumbira muzvigadzirwa zve skincare.
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Nguva yekutumira: Oct-21-2024
