Deazaflavins, synthetic analogs ye riboflavin, inova vatambi vakakosha mune enzymatic catalysis uye redox maitiro.Chimiro chavo chakasiyana uye redox zvimiro zvinovaita akakodzera macofactors eakasiyana ma enzymes ekufambisa maerekitironi zvakanaka uye chiitiko chinokonzeresa.ane vimbiso huru mumunda we pharmacology.Kugona kwaro se antioxidant uye regulator ye cellular metabolism inovhura nzira nyowani dzekutsvagisa uye kupindira kwekurapa.
Deazaflavin, inotorwa kubva ku riboflavin uye yakakosha analogue yeyakasikwa flavin, ine yakasarudzika zvimiro zvakakwezva kutarisisa kwevaongorori munzvimbo dzakasiyana dzekutsvagisa.Deazaflavin, inozivikanwawo se7,8-dimethyl-8-hydroxy-5-deazariboflavin, yakatumidzwa zita reatomu yechinomwe yenitrogen yeisoalloxazine mhete ye riboflavin inotsiviwa nekabhoni atomu.
Iyi shanduko yemaitiro inoisiyanisa kubva kune yayo riboflavin uye inopa yakasarudzika makemikari emhando.Nechimiro chayo chakasiyana, deazaflavin inoita basa rakakosha mune zvakawanda zvipenyu maitiro.
Deazaflavin inonzi yellow-orange compound ine molecular formula yeC16H13N3O2, iyo inoratidzwa ne phenolic hydroxyl boka pa8-nzvimbo.
Rimwe remabasa akatanhamara edeazaflavin kutora chikamu mu biosynthesis yecofactor F420, inowanikwa mune mamwe mabhakitiriya, archaea uye yakaderera eukaryotes.Sechinhu chakakosha chekutakura maerekitironi, F420 inobata basa mukuita redox uye inokurumidza kutamisa maerekitironi pakati pema enzymes.Kuvapo kwedeazaflavin kwakakosha padanho rekupedzisira reF420 synthesis, kushandura riboflavin kuita F420 uye kuwedzera mabasa ayo mazhinji ebhayoloji.
Zvinogona kubatsira zve deazaflavin:
●Anti-kuchembera / Anti-kuchembera
●kudzivirira zvirwere
●Inowedzera Cellular Energy Production
●Antioxidant uye anti-inflammatory properties
●Inosimudzira Hutano Hwouropi uye Basa
●kutsigira immune system
1. Anti-kuchembera / anti-kuchembera
5-Desaflavin powder chinhu chine simba chinopesana nekukwegura chiri kuwana mukurumbira muhutano hwehutano uye hutano.Iyo inozivikanwa kuwedzera kugadzirwa kwemuviri kweNAD +, acoenzymeiyo inoita basa rakakosha musimba metabolism uye kugadzirisa masero.
2. Dzivirira zvirwere
Deazaflavins inoita basa rakakosha mukuita kwe erythropoiesis.Inobatsira kuchengetedza kuumbwa kwakajairika uye kushanda kwemasero matsvuku eropa uye kudzivirira zvirwere zvine hukama seanemia.
3. Inowedzera Cellular Energy Production
Imwe yenzira huru iyo deazaflavin inoshandisa hutano hwayo ndeyekusimudzira kugadzirwa kwesimba remagetsi.Kufanana ne riboflavin, deazaflavin inoshanda seyakakosha coenzyme mumasero metabolism.Nekutora chikamu muketani yekutakura erekitironi uye mamwe maitiro enzymatic, deazaflavin inosimudzira kugadzirwa kwesimba rakakwana, kuve nechokwadi chekushanda kweserura.Ichi chivakwa hachingobatsiri kurwisa kuneta, asi chinotsigirawo hutano hwese uye kugara zvakanaka.
4. Antioxidant uye anti-inflammatory properties
Zvidzidzo zvakaratidza kuti deazaflavin ine yakasimba antioxidant zvimiro zvinoita basa rakakosha mukudzikisa oxidative kusagadzikana uye kurwisa zvinokuvadza zvemahara radicals mumuviri.Oxidative stress yakabatana zvakanyanya nemhando dzakasiyana dzezvirwere zvisingaperi, zvinosanganisira chirwere chemoyo, neurodegenerative chirwere, uye cancer.Iyo yemahara radical-kutsvaira kugona kwedeazaflavin inogona kubatsira kudzivirira muviri kubva kuzvirwere izvi uye kutsigira hupenyu hurefu.
Pamusoro pezvo, tsvagiridzo itsva inoratidza kuti Deazaflavin ine anti-inflammatory properties.Kuzvimba kusingaperi chinhu chinokonzera matambudziko mazhinji ehutano.Nekugadzirisa mhinduro yekuzvimba, deazaflavin inogona kubatsira kurapa nekudzivirira zvirwere zvakaita searthritis, asthma, uye autoimmune zvirwere.
5. Inosimudzira Utano Hwouropi uye Basa
Iyo inogona kuitika neuroprotective mhedzisiro yedeazaflavin zvakare inofarira kune vaongorori vanodzidza cognition uye hutano hwehuropi.Zvirwere zveNeurodegenerative senge chirwere cheAlzheimer uye chirwere cheParkinson chave matambudziko makuru ehutano pasi rese.Kugona kwedeazaflavins kusimudzira kugadzirwa kwesimba remaserura pamwe ne antioxidant uye anti-kuzvimba zvivakwa zvinoita kuti vavimbise vamiriri mukuderedza zvinokonzeresa zvirwere izvi.
Pamusoro pezvo, tsvakiridzo yekutanga inoratidza kuti Deazaflavin inogona kutsigira ndangariro uye yekuziva basa, zvichiita kuti ive mubatsiri anogona kurwisa zera-ane chekuita nekuderera kwekuziva uye kuwedzera hutano hwehuropi hwese.Nekudaro, tsvakiridzo yakazara inodiwa kuti unzwisise zvizere kukura kwedeazaflavin mhedzisiro pahutano hwehuropi.
6. Immune System Support
Dziviriro yedu yemuviri inodzivirira zvirwere uye zvirwere.Basa re deazaflavin seyakakosha coenzyme mune akasiyana enzymatic maitiro rinowedzerawo kune immune system basa.Kutsigira mhinduro yakasimba yekudzivirira muviri kunokosha pakuchengetedza hutano hwakakwana uye kudzivirira zvirwere.Nekusimudzira kugadzirwa kwesimba uye hutano hwakakwana hweserura, deazaflavins inogona kuita basa rakakosha mukutsigira immune system uye kuwedzera kugona kwemuviri wedu kurwisa hutachiona.
Deazaflavin chinhu chakakosha chekudya chinoita basa rakakosha mune dzakasiyana siyana dzemuviri maitiro.Izvi zvinotevera zvimwe zvinogona kuitika uye zviratidzo zvekushomeka kwedeazaflavin:
Ganda uye mucous membrane matambudziko: Kushaikwa kweDeazaflavin kunogona kutungamira mukukura kwezvirwere zveganda senge dermatitis, miromo yakaoma kana yakatsemuka, uye kurwadziwa nehuro.Nzvimbo dzinenge dzabatwa paganda dzinogona kuoma, makwapa, kana kuzvimba.
Matambudziko emaziso: Muzviitiko zvakakomba, kushaikwa kwedeazaflavin kunogona kukonzera matambudziko ane chekuita nemaziso senge photosensitivity uye kusaona.
Anemia: Deazaflavin yakakosha pakugadzirwa kwemasero matsvuku eropa.Kushaikwa kwayo kunogona kutungamirira kuanemia, iyo inoratidzirwa nekuderera kwemasero matsvuku eropa uye kuderedza kukwanisa kutakura oksijeni, zvichiita kuneta, kushaya simba uye kupera kwekufema.
Matambudziko ehutano hwemukanwa nemukanwa: Kushaikwa kweDeazaflavins kunogona kukonzera kukura kwezvinetso zvehutano hwemukanwa senge glossitis (kuzvimba kwerurimi), miromo yakatsemuka, uye maronda emuromo.
Neurologic zviratidzo: Kunyangwe zvisingawanzo, kushaikwa kwakanyanya kweazaflavin kunogona kukanganisa hurongwa hwemitsipa, zvichikonzera zviratidzo zvehurologic zvakadai sekukanganisa kwekuziva, kuvhiringidzika, uye kukuvara kwetsinga.
Deazaflavin ikemikari yakagadziridzwa fomu ye riboflavin (inozivikanwawo sevitamini B2）.Inoshandiswa se cofactor yeakasiyana enzymes mubiotechnology uye molecular biology application.Heano mamwe mazano akazara ekushandisa deazaflavin:
Ita shuwa kuti une nyowani, yemhando yepamusoro zvigadziriso zvemasheya zviripo usati washandisa deazaflavin.Desaflavin inowanzowanikwa muhupfu kana yakasimba fomu, saka ungangoda kuinyungudutsa mune yakakodzera solvent, semvura kana buffered solution.Kana iripo, tevera mirairo yemugadziri wekugadzirisa patsva.
Deazaflavins inonzwa kune chiedza, kupisa uye oxidation.Nokudaro, zvakakosha kuchengetedza mhinduro munzvimbo ine rima, inotonhorera uye kuidzivirira kubva pakuonekwa kwenguva refu kumhepo.Funga nezve aliquoting iyo stock solution muzvikamu zvidiki zvinoraswa kuderedza kudzikira.
Iyo chaiyo yekusangana kwedeazaflavin inodiwa inogona kusiyana zvichienderana ne enzyme kana maitiro ari kudzidzwa.Zvinokurudzirwa kubvunza zvinyorwa kana kubvunza nyanzvi mune yaunoda application kuti uone iyo yakakodzera yekumisikidzwa.
Deazaflavins anowanzo shandiswa nekuwedzera iwo kune reaction musanganiswa kana enzymatic assay masisitimu.Nguva dzekuvharira dzinogona kusiyana zvichienderana neiyo chaiyo yekuyedza protocol.Tevedza mirairo yemugadziri kana kubvunza mabhuku akakodzera kuti uwane nguva nemamiriro ekuita.
Zvakakosha kubatanidza mhinduro dzakakodzera dzekutonga kana mapoka ekudzora asina deazaflavin mukugadzirwa kwekuedza.Aya kudzora achakubatsira iwe kusiyanisa mhedzisiro inokonzerwa neazaflavin kubva kune zvimwe zvinhu muhurongwa hwako.
Nyora mamiriro ekuedza, zvakaonekwa, uye zvinoguma mune yakanyatso kunyorwa fomati.Nyatsoongorora uye kududzira data yakawanikwa kubva mukuedza, kuenzanisa mhedzisiro nekutonga kwakakodzera.
Ziva kuti aya ndiwo nhungamiro uye mashandisirwo chaiwo uye maprotocol anogona kusiyana zvichienderana neyako yekuyedza kuseta uye chinangwa chekushandisa.Iva nechokwadi chekubvunza mabhuku akakodzera kana kutsvaga mazano kune nyanzvi mumunda wako kuti uwane mirairo yakarurama yeimwe ongororo.
Kuchengetedzwa kwedeazaflavin
Kana tichifunga nezvekuchengetedzwa kwedeazaflavin, zvakakosha kuti uzive kuti musanganiswa wakaitwa preclinical uye kuongororwa kwemhuka kuti uone huturu hwayo uye zvinogona kuipa.Zvidzidzo izvi zvakaratidza kuti hapana chinocherechedzwa chakanyanya kana chisingaperi chehupfu, zvichiratidza chimiro chekuchengetedzwa kwekomboni.Nekudaro, zvakakosha kuitisa mimwe miedzo yekiriniki kuti iongorore kuchengetedzeka kwayo muvanhu.
deazaflavin side effects:
Nepo zvidzidzo zvepreclinical zvisina kutaura chero akakosha mhedzisiro yedeazaflavin, zvakakosha kungwarira nezve mashandisiro ayo.Sezvinoita chero komboni, mimwe miedzo yekiriniki inodiwa kuti iongorore kuchengetedzwa kwayo muvanhu uye kuona chero mhedzisiro inogona kuitika kana kusangana kwezvinodhaka.Kurongeka kwakaringana, kutonga uye kutarisa kwemurwere kuchave kwakakosha pakuona kushandiswa kwayo kwakachengeteka.
Q: Zvinotora nguva yakareba sei kuti deazaflavin ishande?
A: Migumisiro yeCalcium deazaflavin inogona kusiyana zvichienderana nemunhu, muyero, uye nzira yekutonga.Nekudaro, kazhinji, zvinotendwa kuti deazaflavin inogona kutora chero kubva pamaminitsi mashoma kusvika maawa mashoma kuti itange kushanda.Zvinokurudzirwa kuonana nenyanzvi yezvehutano kana kutevedzera mirairo yakapihwa nemugadziri kuti uwane rumwe ruzivo rwekuti zvinotora nguva yakareba sei kuti komboni iyi itange kushanda.
Disclaimer: Ichi chinyorwa ndechezvinangwa zveruzivo chete uye hachifanirwe kutorwa sezano rekurapa.Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kushandura hutano hwehutano hwako.
Nguva yekutumira: Jul-10-2023
