Munyika iri kukura yehutano uye hukama hwakanaka, oleoylethanolamide (OEA) yave yakakurumbira yekuwedzera inozivikanwa nekugona kwayo mabhenefiti mukutonga uremu, kutonga kwechido, uye hutano hwese metabolic. Iko kudiwa kwe premium oleoylethanolamide poda zvigadzirwa zvawedzera sezvo vanhu vazhinji vachiziva mabhenefiti ayo. Nekudaro, kuwana yemhando yepamusoro OEA inogona kuve ibasa rinotyisa nekuda kwekuwanda kwesarudzo dziripo.
Nekuziva zvekutarisa uye kwekutenga, unogona kuita sarudzo dzine ruzivo dzinoenderana nezvinangwa zvehutano hwako. Paunosarudza oleoylethanolamide, gara uchiisa pamberi kuchena, kunaka uye kujeka. Nenzira iyi chete iwe unogona kusarudza oleoylethanolamide poda chigadzirwa chinosangana nezvido zvako.
Oleoylethanolamide (OEA),kana oleoylethanolamide, i lipid inowanzoitika inogadzirwa mumuviri, kunyanya mudumbu diki. Inotorwa kubva kune enzymatic reaction yeoleic acid (a monounsaturated fatty acid inowanikwa mumafuta akasiyana-siyana ekudya) uye ethanolamine, iyo yechipiri amide compound inoumbwa ne lipophilic oleic acid uye hydrophilic ethanolamine.
OEA zvakare inongoitika lipid molecule mune dzimwe mhuka uye chirimwa tishu. Inowanikwa zvakanyanya mumhuka nezvirimwa zvinyama zvakaita secocoa poda, soya beans, uye nzungu, asi zvirimo zvakaderera zvakanyanya. Chete kana nharaunda yekunze yachinja kana chikafu chamutswa, masero emuviri matishu Ichi chinhu chinogadzirwa muhuwandu hwakawanda, saka OEA inogona zvakare kushandiswa sechikafu chekuwedzera.
OEA iamphiphilic molecule yagara ichishandiswa seyakagadziriswa uye detergent muindasitiri yemakemikari. Nekudaro, kumwe kutsvagurudza kwakawana kuti OEA inogona kushanda se lipid inosaina molecule mune gut-brain axis uye kuratidza nhevedzano yezviitiko zvipenyu mumuviri, zvinosanganisira: kudzora havi, kuvandudza lipid metabolism, kusimudzira ndangariro uye cognition uye mamwe mabasa. Pakati pavo, mabasa eOEA ekudzora chishuwo uye kuvandudza lipid metabolism akagashira zvakanyanya.
Oleoylethanolamide (OEA) ndeye endogenous lipid inosaina molecule uye ndeye ethanolamine kirasi yemakomponi. Inonyanya kuita basa mumuviri nekugadzirisa maitiro akadai sechido, simba metabolism uye fatty acid oxidation. OEA inonyanya kugadzirwa mudumbu diki uye inokanganisa hurongwa hwetsinga uye metabolic maitiro nekusunga kune chaiwo mareceptor.
Oleylethanolamide inoshanda kuburikidza nemaitiro akati wandei:
● PPAR-α activation: OEA inosunga uye inoita PPAR-α, nyukireya receptor inobatanidzwa mu lipid metabolism, inobatsira kuderedza kudya kwekudya uye kuwedzera kushandiswa kwesimba.
● Kukurudzira lipid oxidation: Nekuita PPAR-α, OEA inogona kuwedzera kuparara kwemafuta acids muchiropa uye kukurudzira kushandiswa kwesimba.
● Kudzora kwegut-brain axis: OEA inokanganisa zviratidzo zvekuguta nekukanganisa vagus nerve, iyo inotakura mashoko pakati pehutu neuropi.
Iyo ECS (Endocannabinoid System) yakaoma cell signing system inosanganisira endocannabinoids (senge cannabinoids), mareceptor avo (CB1 uye CB2), uye ane hukama synthesis uye degradation enzymes. IECS inobata basa rinokosha pakugadzirisa maitiro akasiyana-siyana ehutano hwepanyama, kusanganisira chido, maonero ekurwadziwa, mafungiro, chiyeuchidzo, uye mhinduro dzekudzivirira zvirwere.
Iyo nzira iyo ECS inobata nayo physiological zviitiko ndeiyi inotevera:
Kugadzirisa neuronal kukura uye synaptic plasticity: ECS inobata basa rinokosha mukukura nekuvandudzwa kwemasero etsinga, kusanganisira maitiro akadai neurogenesis, glia formation, neuronal migration, synaptogenesis, uye synaptic pruning. CB1R neAEA vanoita mabasa akakosha panguva yekukura kwevanhu uye vanobatana nekusiyanisa masero uye axonal elongation mukati mepakati tsinga system.
Inogadzirisa marwadzo uye mubairo: Cannabinoids inogadzirisa marwadzo nekuita pane dzakawanda zvinangwa uye yakaratidzwa kubvisa marudzi akasiyana emarwadzo. Iyo ECS yakakoshawo kune mibairo mibairo yezvinhu zvinopinda muropa, zvichipesvedzera zvaunofarira uye maitiro ekudzoka kune akasiyana siyana anopindwa muropa.
Inogadzirisa manzwiro uye ndangariro basa: ECS inobatanidzwa mukugadzirisa kushushikana uye inokanganisa kudzidza, kuchengetedza, kurangarira uye kucherechedzwa maitiro emhando dzakasiyana dzekurangarira. CB1R inobata basa mukushanda kwenzvimbo dzakawanda dzehuropi uye ine zvingangoita zvinodzora mhedzisiro pamanzwiro uye ndangariro.
Inogadzirisa immune system nemamwe mabasa: ECS inowanikwa mumasero ekudzivirira uye inogona kukanganisa basa ravo. AEA inogona kurambidza kuburitswa kwepro-inflammatory cytokines uye kugadzirisa immune function. Mukuwedzera, iyo ECS inobatanidzwawo mukugadzirisa chido, kudya maitiro, uye mabasa ehupenyu ezvirongwa zvenhengo dzakawanda.
Hukama huri pakati peoleoylethanolamine neECS hunonyanya kuratidzwa mune zvinotevera zvinhu:
Kudyidzana: OEA inogona kukanganisa chido uye simba rekuenzanisa nekubatana nema receptors muECS. OEA inofungidzirwa kudzvinyirira kudya uye kukurudzira oxidation yemafuta acids.
Regulatory mechanism: OEA inogona kukanganisa basa reECS nekugadzirisa kuumbwa uye kuora kwe endocannabinoids, zvichiita kuti iite basa musimba metabolism uye chido chekutonga.
Rinogona basa: Nekuda kwebasa ravo mukudzora metabolism uye chishuwo, vaongorori vari kuongorora zvavanogona kuita mukufutisa, metabolic syndrome, uye zvimwe zvirwere zvine hukama.
Kakawanda, kuwirirana pakati peoleoylethanolamine uye endocannabinoid system inzvimbo inoshandiswa yekutsvakurudza uye inogona kupa ruzivo rutsva mukunzwisisa nekurapa zvirwere zvine chokuita nemetabolism.
1. Dzora chido uye kuderedza uremu
OEA chinhu chakakosha chekudya inhibitor, uye basa rayo guru nderekubatsira kuderedza kufutisa. Intraperitoneal jekiseni reOEA rinogona kunyatso kudzikisa kudya kwekudya uye kuwedzera huremu mumakonzo. Oral administration yeOEA inogonawo kuita zvakafanana, asi intracerebroventricular jekiseni reOEA haridaro. Hazvikanganisa kudya kwemakonzo. Iyo huru yekurasikirwa nehuremu mhedzisiro yeOEA ndeyekuti inogona kukurudzira kunzwa kwekuguta, nekudaro kudzora kudya kwakanyanya. Kuwedzera kumwe kuungana kweOEA pakudya kwemakonzo akajairwa kana akafuta kunogona kuderedza havi yembeva nehuremu.
OEA haingodziviriri kunyura kwemafuta emudumbu, asi zvakare inomhanyisa iyo beta oxidation yemafuta acids nekusimudzira iyo hydrolysis ye triglycerides mumatishu eperipheral (chiropa nemafuta), pakupedzisira ichidzikisa kuunganidzwa kwemafuta uye kuwana uremu kudzora.
2. Lower ropa lipids uye kuramba atherosclerosis
Peroxisome proliferator-activated receptor-α (PPAR-α) imhando yekugamuchira yakanyatsoenderana nemabasa emagetsi mumuviri. PPAR-α inotora chikamu mu lipid metabolism nekusunga kune peroxisome proliferator mhinduro chinhu. Kutakurwa kwemetabolic, immune regulation, anti-inflammation, anti-proliferation uye mamwe maitiro ane hukama anowedzera kuita basa mukugadzirisa ropa lipids uye anti-atherosclerosis.
OEA ndeye endocannabinoid analog iyo inogadzirwa kana matishu emuviri amutswa. Zvidzidzo zvakaratidza kuti OEA inoshandisa PPAR-M, inoderedza kusunungurwa kwe endothelin-1, inhibits vasoconstriction uye smooth muscle cell proliferation, inosimudzira vasodilation, uye panguva imwechete inowedzera synthesis ye endothelial nitric oxide synthase uye inokonzera kugadzirwa kwenitric oxide yakawanda. synthase. nitrogen, nekudaro ichidzikisa kugadzirwa kwevascular cell adhesion molecules, kuwana anti-inflammatory effects, uye kuita mhedzisiro yekudzikisa ropa lipids uye anti-atherosclerosis.
3. Dzora bulimia
Binge eating disorder (BED) ndiyo inonyanya kunetsa kudya, inoratidzirwa nekusadzoreka, kumanikidzira kudyisa, kunoperekedzwa nekunzwa kwakanyanya kwekutadza kuzvidzora, kunyara, kuzvipa mhosva, kusemburwa, uye kufunganya.
Kunyangwe izvo zvinokonzeresa kudya zvakanyanya zvisati zvapera, pane humbowo hwekuti kudya uye kushushikana kwehupenyu ndizvo zvinokonzeresa zvekudya zvakanyanya. Zvimwe zvidzidzo zvakaratidza kuti ma neurobiological maitiro ekudya zvakanyanya anotarisa pa activation ye mesocortical limbic dopamine (DA) system uye brain serotonin (5-HT) uye norepinephrine (NA) chiratidzo.
Oleylethanolamide (OEA) inowanzoitika lipid metabolite inoita basa rakakosha mukudzora chishuwo, kutonga kwesimba, uye huremu hwekutonga. Semutongi akakosha wemuviri, OEA inodyidzana neperoxisome proliferator-activated receptor α (PPAR-α) kukurudzira satiety uye kukurudzira mafuta oxidation. Vatsvagiri vanga vachiongorora kugona kwekurapa kweOEA, zvichitungamira mukuvandudzwa kweoleoylethanolamide supplements yakagadzirirwa kutsigira mabasa aya.
Usati watengaOleylethanolamide (OEA) poda, funga zvinotevera zvinhu:
1. Nzwisisa OEA
Zvazviri: OEA ifatty acid ethanolamide inoita basa mukudzora kudya, metabolism, uye simba homeostasis. Inogona kubatsira mukutarisira uremu, kuvandudza lipid metabolism, uye kuwedzera simba rekushandisa.
2. Hunhu uye Kuchena
Kwakabva: Tenga kubva kune vane mukurumbira vatengesi vanopa wechitatu-bato kuyedzwa kwekuchena uye mhando.
Sitifiketi Yekuongorora (CoA): Inovimbisa kuti chigadzirwa chine CoA inosimbisa kuumbwa kwayo uye kusavapo kwezvinosvibisa.
3. Chiyero uye kushandiswa
Inokurudzirwa dosi: Tsvagiridzo yakakurudzirwa dosi uye bvunza nyanzvi yehutano yekurudziro yemunhu.
Mafomu Anodyika: OEA inouya nenzira dzakawanda (hupfu, capsule). Sarudza chigadzirwa chinoenderana nemararamiro ako.
4. Zvinogona kuitika
Common Side Effects: Kunyange zvichiwanzoonekwa zvakachengeteka, vamwe vashandisi vanogona kusangana nemudumbu kusagadzikana kana zvimwe zvidiki mhedzisiro.
Bvunza chiremba wako: Kana uine chirwere chakagara chiripo kana uri kutora mishonga, bvunza mutarisiri wako wehutano usati washandisa.
5. Chimiro chepamutemo
Mitemo: Tarisa mamiriro epamutemo eOEA munyika yako sezvo mirau inogona kusiyana.
6. Kuchengetedza uye hupenyu hwesherufu
Mamiriro Ekuchengetedza: Iva nechokwadi chokuti unonzwisisa kuchengetedza zvakanaka poda kuti uchengetedze kushanda kwayo.
Zuva rekupera: Tarisa zuva rekupera kuti uone kuti uri kutenga chigadzirwa chitsva.
7. Mutengo uye kukosha
Mutengo Kuenzanisa: Enzanisa mitengo kubva kune vakasiyana vatengesi, asi ngwarira mitengo yakaderera zvakanyanya inogona kuratidza yakaderera mhando.
Tenga zvakawanda: Kana ukaronga kuishandisa kwenguva yakareba, funga kutenga zvakawanda sezvo zvichigona kuchengetedza mari.
8. Sanganisa nezvimwe zvinowedzera
Synergistic Effects: Tsvakurudza kuti OEA inodyidzana sei nezvimwe zvinowedzera kana shanduko yechikafu yaungafunga.
Nekufunga nezvezvinhu izvi, unogona kuita sarudzo ine ruzivo paunenge uchitenga oleoylethanolamide poda. Nguva dzose koshesa kuchengeteka uye kunaka paunosarudza kuwedzera.
Mazuva akafamba waisaziva kwaunotenga oleylethanolamine powder. Nhasi, kune nzvimbo dzakawanda kwaunogona kutenga magnesium acetyl taurate poda. Nekuda kweinternet, unogona kutenga chero chinhu pasina kana kusiya imba yako. Kuve online hakungoite kuti basa rako rive nyore, zvakare kunoita kuti ruzivo rwako rwekutenga ruve nyore. Iwe zvakare une mukana wekuverenga zvakawanda nezve iyi inoshamisa oleoylethanolamine usati wafunga kutenga.
Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena Oleoylethanolamide (OEA) upfu.
PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Oleoylethanolamide (OEA) poda inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu Oleoylethanolamide (OEA) poda ndiyo sarudzo yakakwana.
Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.
Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.
Mubvunzo: Chii chinonzi Oleoylethanolamide (OEA) uye ndezvipi zvinobatsira?
A: Oleoylethanolamide (OEA) inonzi lipid inowanzoitika inoita basa mukugadzirisa kudya, metabolism, uye simba rekuenzanisa. Inowanzo shandiswa sechikafu chekuwedzera kwehuremu manejimendi, kusimudzira satiety, uye kuwedzera mafuta metabolism.
Mubvunzo: Ndinoona sei kunaka kweOleoylethanolamide powder?
A: Kuti uone kunaka kweOleoylethanolamide poda, tsvaga zvigadzirwa zvinopa Chitupa cheKuongorora (COA) kubva kune yechitatu-bato lab. Pamusoro pezvo, tarisa kuongororwa kwevatengi, kujeka kwechinhu, uye kana chigadzirwa chacho chisina zvinosvibisa uye mafirita.
Mubvunzo: Chii chandinofanira kufunga kana ndichitenga Oleoylethanolamide powder?
A: Paunenge uchitenga Oleoylethanolamide poda, funga zvinhu zvakaita sekwakabva chigadzirwa, kuwanda kweOEA, kuvapo kwezvimwe zvinowedzera, mukurumbira wemugadziri, uye mhinduro yemutengi. Zvakakoshawo kutarisa kuchengetedza kwakakodzera uye mirairo yekubata.
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Nguva yekutumira: Sep-27-2024
