Kuchembera inzira isingadzivisiki yechisikigo yezvipenyu, inoratidzwa nekuderera zvishoma nezvishoma kwechimiro chemuviri uye kushanda nekufamba kwenguva. Maitiro aya akaoma kunzwisisa uye anotarirwa zvakanyanya nemaitiro asina kujeka kubva kune akasiyana ekunze zvinhu zvakaita semhoteredzo. Kuti vanyatsonzwisisa kumhanya kwekuchembera, vesainzi vakasiya nzira yekuyeresa yechinyakare yemakore kana mazuva uye vakatarisa pane yakanyanya kutetepa chiyero chenguva, vachiedza kuwana zviziviso zvisinganzwisisiki mukuchembera.
Mukuongorora uku, masayendisiti akagadzira nhevedzano yekuchembera biomarkers nehungwaru, pakati peiyo DNA methylation maitiro anonyanya kubata maziso. Seyakakosha epigenetic regulatory mechanism, DNA methylation mapatani anogona kunyatso mepu chimiro chemunhu chazvino chekuchembera, kwete kungoburitsa shanduko yeruzivo rwemajini mukuchembera, asi zvakare kuve yakakosha mukuchembera tsvakiridzo yesainzi. maturusi chaiwo. Kuburikidza nekuongorora kwakadzama kweaya ma biomarker, masayendisiti anogona kuwana muono wezve mamorekuru maitiro ari kumashure kwekuchembera, kuvhura nzira nyowani dzekunonoka kuchembera uye kukurudzira kuchembera kune hutano.
Mudenga rakakura rine nyeredzi resainzi inorwisa kuchembera, NMN (nicotinamide mononucleotide) yakambotenderera kunge meteor inopenya. Kuzivikanwa kwayo seyekutanga kweNAD + (nicotinamide adenine dinucleotide) yakafuridzira masayendisiti asingaverengeki. chido chekutsvakurudza. Nekudaro, nekufamba kwenguva, imwe nyeredzi inopenya, AKG (alpha-ketoglutarate), zvishoma nezvishoma yakabuda uye yakahwina kuzivikanwa kwakafara mumunda wekurwisa kuchembera nekunaka kwayo uye nesainzi hwaro. .
Mune chidzidzo chakaburitswa mujenari Nature Metabolism, masayendisiti akatsanangura nezve magadzirirwo eAKG musimba metabolism, mitochondrial basa uye anti-kuchembera. Chidzidzo ichi chakaratidza kuti AKG inogona kusimudzira zvakananga tricarboxylic acid kutenderera uye kuwedzera simba rinobuda mumaseru, nekudaro ichiwedzera simba rose remasero. Pamusoro pezvo, bhuku re "Cell Metabolism" rakaburitsawo mhedzisiro yekutsvagisa pamusoro pekugona kweAKG kusimudzira collagen synthesis uye kuvandudza elasticity yeganda, zvichisimbisa kugona kwayo mumunda wekurwisa kuchembera.
Kudzoreredza zvisaririra zvenguva
Chidzidzo chekiriniki kubva kuJapan chinotipa muenzaniso wakajeka. Mukadzi wepakati-kati ave achiteerera kurwisa-kuchembera kwenguva yakareba, mushure mekutora AKG yekuwedzera kwehafu yegore, kwete chete mamiriro eganda rake akavandudzwa zvakanyanya, achive akasimba uye akawedzera elastic, asi muviri wake wese. uye chimiro chendangariro chakavandudzwawo zvikuru. Nekuenzanisa zviratidzo zvemuviri zvisati zvaitika uye mushure mekuedza, vaongorori vakawana kuti basa remukadzi remitochondrial rakakwidziridzwa zvakanyanya, iro rine hukama hwepedyo nebasa reAKG mukusimudzira metabolism yesimba.
Muchengeti wehutano hwehutano
Chimwe chidzidzo kubva kuUnited States chakanangana nebasa reurouroprotective reAKG. Mushure mekugamuchira kurapwa kweAKG, mumwe murume wechikuru aive nekusakwana kwekuziva akataridza kuvandudzwa kukuru mukugona kwake kwekuziva, kusanganisira kuvandudza ndangariro uye kuisa pfungwa. Vatsvagiri vakacherekedza kuburikidza nehunyanzvi hwekufungidzira huropi kuti murwere neuron mitochondrial basa rakadzoreredzwa, izvo zvinopa rutsigiro rwakasimba rweAKG mukudzivirira nekurapa zvirwere zveurourodegenerative.
AKG yakasarudzika mabhenefiti
1. Multi-dimensional anti-aging effect
Kusiyana neNMN, iyo inonyanya kurwisa kuchembera nekuwedzera NAD + mazinga, AKG inoita basa rakawanda mukurwisa kuchembera. Haikwanise kungosimudzira simba remetabolism uye kuwedzera mitochondrial basa, asi zvakare kuvandudza mamiriro ekukwegura kwemuviri kubva kune akawanda mativi nekukanganisa amino acid metabolism uye kukurudzira collagen synthesis.
2. Yakakwirira biocompatibility uye kuchengeteka
Semetabolite inongoitika yemuviri wemunhu, AKG ine yakanakisa biocompatibility uye chengetedzo. Inogona kunyudzwa zvakananga uye kushandiswa nemuviri wemunhu pasina kuenda nenzira yakaoma yekutendeuka, ichidzikisa njodzi yekugona kuita kwakashata. Izvi zvinoita kuti kushandiswa kweAKG mumunda wekurwisa kuchembera kuve kwakachengeteka uye kwakavimbika.
3. Yakasiyana-siyana yehutano inobatsira
Pamusoro pekurwisa kuchembera, AKG inoratidzawo hutano hwakasiyana-siyana mukusimudzira hutano hwetsinga uye kuwedzera kusadzivirirwa. Aya ekuwedzera hutano mabhenefiti anoita kuti AKG iwedzere kutaridzika kune anti-kuchembera maapplication.
Nekuenderera mberi nekudzika kwekutsvagisa kwesainzi uye kuenderera mberi kwehunyanzvi tekinoroji, tarisiro yekushandiswa kweAKG mumunda wekurwisa kuchembera ichave yakakura. Isu tinotarisira kutsvagurudzo yemhando yepamusoro mune ramangwana kuburitsa zvimwe zvakavanzika zveAKG, uye zvakare tinotarisira kugona kwayo kusanganiswa nedzimwe nzira dzekurwisa kuchembera dzakaita seNMN kuti tipe pamwe huchenjeri huzhinji nesimba kuhutano hwevanhu uye hupenyu hurefu. . Mumujaho uyu uchipesana nenguva, AKG yakaratidza pasina mubvunzo kukwikwidza kwakasimba uye mikana isingaperi.
Mabasa makuru ndeaya:
Anti-kuchembera: Inogona kunonoka zvakanyanya kuchembera kwemasero nekugadzirisa nzira yekuratidzira mTOR, kukurudzira autophagy, kuvandudza mapuroteni metabolism abnormalities, uye kudzora epigenetics. Uye zvakare, inogona kusimudzira collagen synthesis, kutsigira sero detoxification, kubatsira kudzoreredza yakajairwa calcium mazinga muropa, kukurumidza kuporeswa kwemaronda, kukurudzira kugadzirisa mhasuru, nezvimwe.
Kuvandudza zvirwere zvisingaperi: Kuongororwa kwekiriniki kwakaratidza kuti ine hukuru hwekuvandudza hutano kune zvakasiyana-siyana zvirwere zvisingaperi, kusanganisira asi kwete kungoita osteoporosis, neurodegenerative zvirwere (zvakadai sechirwere cheParkinson), zvirwere zvemwoyo, chirwere cheshuga, uye kenza. Inogadzirisa zvinokonzeresa zvirwere zvisingaperi nekuita mapuroteni ehupenyu hurefu mumuviri uye kugadzirisa DNA yakakanganisika.
Kuvandudza kusadzivirirwa kwezvirwere: Inogona kukwidziridza chiitiko uye kuwanda kwemaseru edziviriro, kuvandudza kusadzivirirwa kwemuviri kwese, uye nekudaro kubatsira muviri kurwisa zvirwere nehutachiona.
Kurudzira hutano: Ichi chigadzirwa chinewo mabhenefiti akadai sekusimudzira metabolism yeshuga yeropa nemafuta mumuviri uye kutsigira hutano hwehuropi hwekuziva basa, zvichibatsira kuchengetedza hutano hwese hwemuviri wemunhu.
Anti-kuchembera mhedzisiro inotsigirwa netsvakiridzo yesainzi. Somuenzaniso, muna 2014, magazini yepamusoro "Nature" yakashuma kwekutanga kuti kukwegura kunogona kunonoka nekudzivisa basa reMTOR; tsvakiridzo pamasero emunhu osteosarcoma yakaratidzawo kuti inogona kusimudzira autophagy; uyezve, inogonawo kutora chikamu mukuumbwa kweamino acids uye kuderedza mapuroteni metabolism. Zvisizvo zvinoitika uye zvinobatanidzwa mu epigenetic regulatory maitiro akadai seDNA demethylation.
Miedzo yemakiriniki yakawedzera kusimbisa kuchengetedzwa kwayo uye kushanda kwayo. Semuyenzaniso, Phase I human clinical trial report yakapihwa neNewMed Hospital muCalifornia inoratidza kuti ine mhedzisiro yakakosha yekurapa pane dzakasiyana siyana dzechirwere chisingaperi zviratidzo sekushaya hope, kurasikirwa nendangariro, kutadza kwerenal, sitiroko sequelae, uye inogona zvakare kurapa kupfupika. kufema, kuneta, uye zvimwe zviratidzo zvinokonzerwa neiyo coronavirus itsva. Iyo zvakare ine yakanakisa kugadzirisa maitiro pane sequelae senge kukosora.
Nekuita kwayo kunoshamisa uye kuchengeteka, yakahwina kutariswa kwakapararira uye kurumbidzwa mumusika. Vazhinji vashandisi vakarondedzera kuvandudzwa kwakakosha mumamiriro avo emuviri mushure mekuitora, senge simba rakawanda, rakasimba uye rakawanda ganda rakatsetseka, etc. Panguva imwecheteyo, chigadzirwa ichi chave chichizivikanwa uye chakatsigirwa nemasangano mazhinji ane chiremera uye nyanzvi.
Kupfupisa, Calcium Alpha ketoglutarate isayenzi, yakachengeteka uye inoshanda inorwisa kuchembera chigadzirwa. Inowana anti-kuchembera mhedzisiro uye inovandudza zviratidzo zvezvirwere zvakasiyana-siyana zvisingaperi kuburikidza nenzira dzakawanda. Icho chisarudzo chakanaka kune vanhu vanotsvaga hutano uye hupenyu hurefu.
Nguva yekutumira: Jul-08-2024
