Alpha-ketoglutarate (AKG kwenguva pfupi) yakakosha metabolic yepakati inoita basa rakakosha mumuviri wemunhu, kunyanya musimba metabolism, antioxidant mhinduro, uye kugadzirisa masero.
Mumakore achangopfuura, AKG yakagamuchira kutariswa kwekugona kwayo kunonoka kuchembera nekurapa zvirwere zvisingaperi. Heano maitiro chaiwo ekuita kweAKG mune aya maitiro:
AKG inotamba mabasa akawanda mukugadzirisa DNA, ichibatsira kuchengetedza kuvimbika kweDNA kuburikidza nenzira dzinotevera:
Sezvinoita cofactor ye hydroxylation reactions: AKG is a cofactor for many dioxygenases (akadai seTET enzymes uye PHDs enzymes).
Aya ma enzymes anobatanidzwa muDNA demethylation uye histone modification, kuchengetedza genome kugadzikana uye kudzora gene kutaura.
TET enzyme inokonzeresa demethylation ye5-methylcytosine (5mC) uye inoishandura kuita 5-hydroxymethylcytosine (5hmC), nokudaro ichigadzirisa gene kutaura.
Nekutsigira basa rema enzymes aya, AKG inobatsira kugadzirisa kukuvara kweDNA uye kuchengetedza genome kuvimbika.
Antioxidant mhedzisiro: AKG inogona kuderedza kukuvadzwa kweDNA kunokonzerwa neoxidative kusagadzikana nekumisa mahara radicals uye reactive oxygen marudzi (ROS).
Oxidative kusagadzikana chinhu chakakosha chinotungamira kukuvara kweDNA uye kuchembera kwemasero. Nekusimudzira iyo antioxidant kugona kwemasero, AKG inogona kubatsira kudzivirira kukuvara kweDNA kune chekuita neoxidative kusagadzikana.
Gadzirisa masero uye matishu
AKG inoita basa rakakosha mukugadzirisa masero uye kuvandudzwa kwetishu, kunyanya kuburikidza nedzinotevera nzira:
Kurudzira stem cell basa: AKG inogona kusimudzira chiitiko uye regenerative kugona kwe stem maseru. Tsvagiridzo inoratidza kuti AKG inogona kuwedzera hupenyu hwema stem maseru, kusimudzira kusiyanisa kwavo uye kuwanda, uye nekudaro inobatsira mukuvandudzwa kwetishu uye kugadzirisa.
Nekuchengetedza basa rema stem maseru, AKG inogona kunonoka kuchembera kwetishu uye kugadzirisa kugona kwemuviri kudzoreredza.
Kuvandudza sero metabolism uye autophagy: AKG inotora chikamu muiyo tricarboxylic acid kutenderera (TCA kutenderera) uye yakakosha yepakati chigadzirwa cheserura simba metabolism.
Nekusimudzira kushanda kweTCA kutenderera, AKG inogona kuwedzera masero emagetsi mazinga uye kutsigira kugadziridzwa kwesero uye kugadzirisa kwekushanda.
Mukuwedzera, AKG yakawanikwa ichikurudzira maitiro e autophagy, kubatsira masero kubvisa zvinhu zvakakanganisika uye kuchengetedza hutano hwesero.
Gene balance uye epigenetic regulation
AKG inoita basa rakakosha mukuenzanisa kwemajini uye epigenetic regulation, ichibatsira kuchengetedza yakajairika basa uye hutano hwemasero:
Inofurira epigenetic regulation: AKG inogadzirisa maitiro ekutaura kwemajini nekutora chikamu mukugadziriswa kwe epigenetic, senge demethylation yeDNA uye histones.
Epigenetic regulation ndiyo yakakosha yekudzora nzira yejini kutaura uye sero basa. Basa reAKG rinogona kubatsira kuchengetedza zvakajairwa kutaura kwemajini uye kudzivirira zvirwere uye kuchembera kunokonzerwa neabnormal gene expression.
Inhibit inflammatory response: AKG inogona kuderedza mhinduro yekusingaperi inoputika inobatanidza nekukwegura nekugadzirisa gene expression.
Kuzvimba kusingaperi kunoenderana nezvirwere zvakawanda zvine chekuita nekuchembera, uye anti-kuzvimba mhedzisiro yeAKG inogona kubatsira kudzivirira nekudzikisa mamiriro aya.
Kunonoka kuchembera uye kubata zvirwere zvisingaperi
Zviito zvakawanda zveAKG zvinopa mukana mukunonoka kuchembera nekurapa zvirwere zvisingaperi:
Kunonoka kuchembera: Nekusimudzira kugadzirisa kweDNA, kusimudzira antioxidant simba, kutsigira stem cell basa, kudzora gene kutaura, nezvimwewo, AKG inogona kunonoka kuchembera kwemaseru nematishu.
Zvidzidzo zvemhuka zvinoratidza kuti kuwedzera neAKG kunogona kuwedzera hupenyu uye kugadzirisa hutano mumhuka dzakura.
Kurapa kwezvirwere zvisingaperi: Mhedzisiro yeAKG mukuvandudza metabolic basa, anti-inflammation, uye antioxidant inoita kuti ive yakakosha mukurapa kwezvirwere zvisingaperi.
Semuyenzaniso, AKG inogona kuva nekudzivirira uye kurapa mhedzisiro pachirwere cheshuga, chirwere chemoyo, chirwere cheurourodegenerative, nezvimwe.
Pfupisa
AKG inoita basa mukunonotsa kuchembera uye kurapa zvirwere zvisingaperi nekugadzirisa DNA, kusimudzira masero uye kugadzirwa kwetishu, kuchengetedza gene balance uye kudzora epigenetics.
Iyo synergistic mhedzisiro yemaitiro aya inoita kuti AKG ive inovimbisa chinangwa chekurwisa kuchembera uye chirwere chisingaperi chinopindira.
Mune ramangwana, kumwe kutsvagisa kuchabatsira kuburitsa mamwe mabhenefiti eAKG uye mikana yekushandiswa kwayo.
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Nguva yekutumira: Sep-05-2024
